Drinking and feeding inhibition by ICV pulse injection or infusion of bombesin, ranatensin and litorin to rats
The effects on ingestive behavior of the naturally occurring bombesin-like peptides ranatensin and litorin were studied in comparison to those of bombesin by intracerebroventricular pulse injection or by continuous infusion in the rat. Ranatensin and litorin, like bombesin, proved to inhibit drinkin...
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| Veröffentlicht in: | Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1984-01, Vol.5 (3), p.607-613 |
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| container_title | Peptides (New York, N.Y. : 1980) |
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| creator | de Caro, G. Massi, M. Micossi, L.G. Perfumi, M. |
| description | The effects on ingestive behavior of the naturally occurring bombesin-like peptides ranatensin and litorin were studied in comparison to those of bombesin by intracerebroventricular pulse injection or by continuous infusion in the rat. Ranatensin and litorin, like bombesin, proved to inhibit drinking and feeding behavior. Marked differences, however, were observed in their effects. In particular our results indicate that these peptides possess different selectivity of action on drinking elicited by different dipsogenic stimuli and different potency and effectiveness in inhibiting food intake induced by food deprivation. Moreover, the effects of the three peptides were markedly affected also by the modality of administration (pulse injection or continuous infusion). On the basis of these results it seems possible to hypothesize that the endogenous bombesin-like peptides may differently affect rat ingestive behavior according to their structure and to the rate and modality of their release in the brain. |
| doi_str_mv | 10.1016/0196-9781(84)90091-3 |
| format | Article |
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Ranatensin and litorin, like bombesin, proved to inhibit drinking and feeding behavior. Marked differences, however, were observed in their effects. In particular our results indicate that these peptides possess different selectivity of action on drinking elicited by different dipsogenic stimuli and different potency and effectiveness in inhibiting food intake induced by food deprivation. Moreover, the effects of the three peptides were markedly affected also by the modality of administration (pulse injection or continuous infusion). On the basis of these results it seems possible to hypothesize that the endogenous bombesin-like peptides may differently affect rat ingestive behavior according to their structure and to the rate and modality of their release in the brain.</description><identifier>ISSN: 0196-9781</identifier><identifier>EISSN: 1873-5169</identifier><identifier>DOI: 10.1016/0196-9781(84)90091-3</identifier><identifier>PMID: 6473174</identifier><identifier>CODEN: PPTDD5</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Behavioral psychophysiology ; Biological and medical sciences ; Bombesin ; Bombesin - administration & dosage ; Bombesin - pharmacology ; Drinking behavior ; Drinking Behavior - drug effects ; Feeding behavior ; Feeding Behavior - drug effects ; Food Deprivation ; Fundamental and applied biological sciences. Psychology ; Injections, Intraventricular ; Kinetics ; Litorin ; Male ; Oligopeptides - administration & dosage ; Oligopeptides - pharmacology ; Peptides - pharmacology ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Pyrrolidonecarboxylic Acid - analogs & derivatives ; Ranatensin ; Rat ; Rats ; Rats, Inbred Strains ; Time Factors ; Vasoconstrictor Agents - pharmacology</subject><ispartof>Peptides (New York, N.Y. : 1980), 1984-01, Vol.5 (3), p.607-613</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-fbb26ab8fd3141d43e38960b5b2187075a38cbf18654904f5214725dda5148303</citedby><cites>FETCH-LOGICAL-c417t-fbb26ab8fd3141d43e38960b5b2187075a38cbf18654904f5214725dda5148303</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0196-9781(84)90091-3$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9071585$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6473174$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>de Caro, G.</creatorcontrib><creatorcontrib>Massi, M.</creatorcontrib><creatorcontrib>Micossi, L.G.</creatorcontrib><creatorcontrib>Perfumi, M.</creatorcontrib><title>Drinking and feeding inhibition by ICV pulse injection or infusion of bombesin, ranatensin and litorin to rats</title><title>Peptides (New York, N.Y. : 1980)</title><addtitle>Peptides</addtitle><description>The effects on ingestive behavior of the naturally occurring bombesin-like peptides ranatensin and litorin were studied in comparison to those of bombesin by intracerebroventricular pulse injection or by continuous infusion in the rat. Ranatensin and litorin, like bombesin, proved to inhibit drinking and feeding behavior. Marked differences, however, were observed in their effects. In particular our results indicate that these peptides possess different selectivity of action on drinking elicited by different dipsogenic stimuli and different potency and effectiveness in inhibiting food intake induced by food deprivation. Moreover, the effects of the three peptides were markedly affected also by the modality of administration (pulse injection or continuous infusion). On the basis of these results it seems possible to hypothesize that the endogenous bombesin-like peptides may differently affect rat ingestive behavior according to their structure and to the rate and modality of their release in the brain.</description><subject>Animals</subject><subject>Behavioral psychophysiology</subject><subject>Biological and medical sciences</subject><subject>Bombesin</subject><subject>Bombesin - administration & dosage</subject><subject>Bombesin - pharmacology</subject><subject>Drinking behavior</subject><subject>Drinking Behavior - drug effects</subject><subject>Feeding behavior</subject><subject>Feeding Behavior - drug effects</subject><subject>Food Deprivation</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Injections, Intraventricular</subject><subject>Kinetics</subject><subject>Litorin</subject><subject>Male</subject><subject>Oligopeptides - administration & dosage</subject><subject>Oligopeptides - pharmacology</subject><subject>Peptides - pharmacology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Pyrrolidonecarboxylic Acid - analogs & derivatives</subject><subject>Ranatensin</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Time Factors</subject><subject>Vasoconstrictor Agents - pharmacology</subject><issn>0196-9781</issn><issn>1873-5169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUuPFCEUhYnRjO3oP9CkFsZoMqXc4r0xMa2Ok0ziRt0SoEAZq6EHqiaZfy_9SC-dFZd7Pw5wDkIvAb8HDPwDBsV7JSS8lfSdwlhBTx6hFUhBegZcPUarE_IUPav1BmNMqZJn6IxTQUDQFUqfS0x_Y_rdmTR2wftxV8f0J9o4x5w6e99drX9122WqvvVvvNu3c2mbsNR9HTqbN9bXmC66YpKZfWr1XnGKc243dHNuk7k-R0-CaUovjus5-vn1y4_1t_76--XV-tN17yiIuQ_WDtxYGUYCFEZKPJGKY8vs0L6HBTNEOhtAckYVpoENQMXAxtEwoJJgco7eHHS3Jd8uvs56E6vz02SSz0vVEgYCnIsHQaCEDorwBtID6EqutfigtyVuTLnXgPUuD70zW-_M1pLqfR6atGOvjvqL3fjxdOgYQJu_Ps5NdWYKzT4X6wlTWACTrGEfD5hvpt1FX3R10SfX4iotET3m-P93_AOdtqX8</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>de Caro, G.</creator><creator>Massi, M.</creator><creator>Micossi, L.G.</creator><creator>Perfumi, M.</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Drinking and feeding inhibition by ICV pulse injection or infusion of bombesin, ranatensin and litorin to rats</title><author>de Caro, G. ; Massi, M. ; Micossi, L.G. ; Perfumi, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-fbb26ab8fd3141d43e38960b5b2187075a38cbf18654904f5214725dda5148303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Behavioral psychophysiology</topic><topic>Biological and medical sciences</topic><topic>Bombesin</topic><topic>Bombesin - administration & dosage</topic><topic>Bombesin - pharmacology</topic><topic>Drinking behavior</topic><topic>Drinking Behavior - drug effects</topic><topic>Feeding behavior</topic><topic>Feeding Behavior - drug effects</topic><topic>Food Deprivation</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Injections, Intraventricular</topic><topic>Kinetics</topic><topic>Litorin</topic><topic>Male</topic><topic>Oligopeptides - administration & dosage</topic><topic>Oligopeptides - pharmacology</topic><topic>Peptides - pharmacology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Pyrrolidonecarboxylic Acid - analogs & derivatives</topic><topic>Ranatensin</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Time Factors</topic><topic>Vasoconstrictor Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>de Caro, G.</creatorcontrib><creatorcontrib>Massi, M.</creatorcontrib><creatorcontrib>Micossi, L.G.</creatorcontrib><creatorcontrib>Perfumi, M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Peptides (New York, N.Y. : 1980)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>de Caro, G.</au><au>Massi, M.</au><au>Micossi, L.G.</au><au>Perfumi, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drinking and feeding inhibition by ICV pulse injection or infusion of bombesin, ranatensin and litorin to rats</atitle><jtitle>Peptides (New York, N.Y. : 1980)</jtitle><addtitle>Peptides</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>5</volume><issue>3</issue><spage>607</spage><epage>613</epage><pages>607-613</pages><issn>0196-9781</issn><eissn>1873-5169</eissn><coden>PPTDD5</coden><abstract>The effects on ingestive behavior of the naturally occurring bombesin-like peptides ranatensin and litorin were studied in comparison to those of bombesin by intracerebroventricular pulse injection or by continuous infusion in the rat. Ranatensin and litorin, like bombesin, proved to inhibit drinking and feeding behavior. Marked differences, however, were observed in their effects. In particular our results indicate that these peptides possess different selectivity of action on drinking elicited by different dipsogenic stimuli and different potency and effectiveness in inhibiting food intake induced by food deprivation. Moreover, the effects of the three peptides were markedly affected also by the modality of administration (pulse injection or continuous infusion). On the basis of these results it seems possible to hypothesize that the endogenous bombesin-like peptides may differently affect rat ingestive behavior according to their structure and to the rate and modality of their release in the brain.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>6473174</pmid><doi>10.1016/0196-9781(84)90091-3</doi><tpages>7</tpages></addata></record> |
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| issn | 0196-9781 1873-5169 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Behavioral psychophysiology Biological and medical sciences Bombesin Bombesin - administration & dosage Bombesin - pharmacology Drinking behavior Drinking Behavior - drug effects Feeding behavior Feeding Behavior - drug effects Food Deprivation Fundamental and applied biological sciences. Psychology Injections, Intraventricular Kinetics Litorin Male Oligopeptides - administration & dosage Oligopeptides - pharmacology Peptides - pharmacology Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Pyrrolidonecarboxylic Acid - analogs & derivatives Ranatensin Rat Rats Rats, Inbred Strains Time Factors Vasoconstrictor Agents - pharmacology |
| title | Drinking and feeding inhibition by ICV pulse injection or infusion of bombesin, ranatensin and litorin to rats |
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