Mating and Pregnancy Can Occur in Genetically Hypogonadal Mice with Preoptic Area Brain Grafts
Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1984-08, Vol.225 (4665), p.949-951 |
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| container_issue | 4665 |
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| container_title | Science (American Association for the Advancement of Science) |
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| creator | Gibson, Marie J. Krieger, Dorothy T. Charlton, Harry M. Zimmerman, Earl A. Silverman, Ann-Judith Perlow, Mark J. |
| description | Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains. |
| doi_str_mv | 10.1126/science.6382608 |
| format | Article |
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Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.6382608</identifier><identifier>PMID: 6382608</identifier><language>eng</language><publisher>United States: The American Association for the Advancement of Science</publisher><subject>Animals ; Brain Chemistry ; Cerebral Ventricles - pathology ; Copulation ; Endocrinology, Experimental ; Female ; Female animals ; Fetus ; Gonadotropin ; Gonadotropins ; House mouse ; Hypogonadism - genetics ; Hypogonadism - pathology ; Hypogonadism - physiopathology ; Infertility, Female - etiology ; Infertility, Female - therapy ; Male ; Mating behavior ; Median eminence ; Mice ; Mice as laboratory animals ; Neurobiology ; Neurons - analysis ; Ovulation ; Physiological aspects ; Pituitary Hormone-Releasing Hormones - analysis ; Pituitary Hormone-Releasing Hormones - deficiency ; Pregnancy ; Preoptic Area - transplantation ; Reproduction ; Third ventricle ; Tissue grafting ; Tissue transplantation ; Transplantation</subject><ispartof>Science (American Association for the Advancement of Science), 1984-08, Vol.225 (4665), p.949-951</ispartof><rights>Copyright 1984 The American Association for the Advancement of Science</rights><rights>COPYRIGHT 1984 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1984 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c580t-d48cf3724949d2da564563cd6cc212f119f9bb0c48cf255018904819d4ae787b3</citedby><cites>FETCH-LOGICAL-c580t-d48cf3724949d2da564563cd6cc212f119f9bb0c48cf255018904819d4ae787b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1693960$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1693960$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,777,781,800,2871,2872,27905,27906,57998,58231</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6382608$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gibson, Marie J.</creatorcontrib><creatorcontrib>Krieger, Dorothy T.</creatorcontrib><creatorcontrib>Charlton, Harry M.</creatorcontrib><creatorcontrib>Zimmerman, Earl A.</creatorcontrib><creatorcontrib>Silverman, Ann-Judith</creatorcontrib><creatorcontrib>Perlow, Mark J.</creatorcontrib><title>Mating and Pregnancy Can Occur in Genetically Hypogonadal Mice with Preoptic Area Brain Grafts</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains.</description><subject>Animals</subject><subject>Brain Chemistry</subject><subject>Cerebral Ventricles - pathology</subject><subject>Copulation</subject><subject>Endocrinology, Experimental</subject><subject>Female</subject><subject>Female animals</subject><subject>Fetus</subject><subject>Gonadotropin</subject><subject>Gonadotropins</subject><subject>House mouse</subject><subject>Hypogonadism - genetics</subject><subject>Hypogonadism - pathology</subject><subject>Hypogonadism - physiopathology</subject><subject>Infertility, Female - etiology</subject><subject>Infertility, Female - therapy</subject><subject>Male</subject><subject>Mating behavior</subject><subject>Median eminence</subject><subject>Mice</subject><subject>Mice as laboratory animals</subject><subject>Neurobiology</subject><subject>Neurons - analysis</subject><subject>Ovulation</subject><subject>Physiological aspects</subject><subject>Pituitary Hormone-Releasing Hormones - analysis</subject><subject>Pituitary Hormone-Releasing Hormones - deficiency</subject><subject>Pregnancy</subject><subject>Preoptic Area - transplantation</subject><subject>Reproduction</subject><subject>Third ventricle</subject><subject>Tissue grafting</subject><subject>Tissue transplantation</subject><subject>Transplantation</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s9v0zAUB_AIgUYZnLmA5BMcRjb_SBz72FWjm9RRJH4csVzHCZ5cu7Mdsf73uGrEhtRD5YMlfz_vSdZ7RfEWwXOEML2Iymin9DklDFPInhUTBHldcgzJ82ICIaElg039sngV4x2EOePkpDgZ-aT4dSuTcT2QrgVfg-6ddGoLZtKBpVJDAMaBuXY6GSWt3YLr7cb33slWWnBrlAZ_TPq9K_SbTMA0aAkug9xVBdml-Lp40Ukb9ZvxPi1-fL76PrsuF8v5zWy6KFXNYCrbiqmONLjiFW9xK2ta1ZSoliqFEe4Q4h1fraDaMVzXEDEOK4Z4W0ndsGZFTosP-76b4O8HHZNYm6i0tdJpP0TBECaQM5zh2R720mphXOdTkKrPXwzSeqc7k5-npIK0bljWnw7ofFq9NuoA__gfzyLph9TLIUZx8-3LsXL581h5OT9SsvniqTw7JJW3Vvda5MnMlk_1xV6r4GMMuhObYNYybAWCYreEYlxCMW5Vrng_TmNYrXX7zz_m7_b5XUw-PLajnHAKyV_JuN2x</recordid><startdate>19840831</startdate><enddate>19840831</enddate><creator>Gibson, Marie J.</creator><creator>Krieger, Dorothy T.</creator><creator>Charlton, Harry M.</creator><creator>Zimmerman, Earl A.</creator><creator>Silverman, Ann-Judith</creator><creator>Perlow, Mark J.</creator><general>The American Association for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7X8</scope></search><sort><creationdate>19840831</creationdate><title>Mating and Pregnancy Can Occur in Genetically Hypogonadal Mice with Preoptic Area Brain Grafts</title><author>Gibson, Marie J. ; Krieger, Dorothy T. ; Charlton, Harry M. ; Zimmerman, Earl A. ; Silverman, Ann-Judith ; Perlow, Mark J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c580t-d48cf3724949d2da564563cd6cc212f119f9bb0c48cf255018904819d4ae787b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Brain Chemistry</topic><topic>Cerebral Ventricles - pathology</topic><topic>Copulation</topic><topic>Endocrinology, Experimental</topic><topic>Female</topic><topic>Female animals</topic><topic>Fetus</topic><topic>Gonadotropin</topic><topic>Gonadotropins</topic><topic>House mouse</topic><topic>Hypogonadism - genetics</topic><topic>Hypogonadism - pathology</topic><topic>Hypogonadism - physiopathology</topic><topic>Infertility, Female - etiology</topic><topic>Infertility, Female - therapy</topic><topic>Male</topic><topic>Mating behavior</topic><topic>Median eminence</topic><topic>Mice</topic><topic>Mice as laboratory animals</topic><topic>Neurobiology</topic><topic>Neurons - analysis</topic><topic>Ovulation</topic><topic>Physiological aspects</topic><topic>Pituitary Hormone-Releasing Hormones - analysis</topic><topic>Pituitary Hormone-Releasing Hormones - deficiency</topic><topic>Pregnancy</topic><topic>Preoptic Area - transplantation</topic><topic>Reproduction</topic><topic>Third ventricle</topic><topic>Tissue grafting</topic><topic>Tissue transplantation</topic><topic>Transplantation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gibson, Marie J.</creatorcontrib><creatorcontrib>Krieger, Dorothy T.</creatorcontrib><creatorcontrib>Charlton, Harry M.</creatorcontrib><creatorcontrib>Zimmerman, Earl A.</creatorcontrib><creatorcontrib>Silverman, Ann-Judith</creatorcontrib><creatorcontrib>Perlow, Mark J.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale In Context: Biography</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gibson, Marie J.</au><au>Krieger, Dorothy T.</au><au>Charlton, Harry M.</au><au>Zimmerman, Earl A.</au><au>Silverman, Ann-Judith</au><au>Perlow, Mark J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mating and Pregnancy Can Occur in Genetically Hypogonadal Mice with Preoptic Area Brain Grafts</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1984-08-31</date><risdate>1984</risdate><volume>225</volume><issue>4665</issue><spage>949</spage><epage>951</epage><pages>949-951</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains.</abstract><cop>United States</cop><pub>The American Association for the Advancement of Science</pub><pmid>6382608</pmid><doi>10.1126/science.6382608</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1984-08, Vol.225 (4665), p.949-951 |
| issn | 0036-8075 1095-9203 |
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| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Animals Brain Chemistry Cerebral Ventricles - pathology Copulation Endocrinology, Experimental Female Female animals Fetus Gonadotropin Gonadotropins House mouse Hypogonadism - genetics Hypogonadism - pathology Hypogonadism - physiopathology Infertility, Female - etiology Infertility, Female - therapy Male Mating behavior Median eminence Mice Mice as laboratory animals Neurobiology Neurons - analysis Ovulation Physiological aspects Pituitary Hormone-Releasing Hormones - analysis Pituitary Hormone-Releasing Hormones - deficiency Pregnancy Preoptic Area - transplantation Reproduction Third ventricle Tissue grafting Tissue transplantation Transplantation |
| title | Mating and Pregnancy Can Occur in Genetically Hypogonadal Mice with Preoptic Area Brain Grafts |
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