Tumour formation in hamsters inoculated with chick embryo lethal orphan virus

Department of Animal Pathology, University of Rhode Island, Kingston, Rhode Island 02881, U.S.A. Weanling hamsters were inoculated subcutaneously in the cheek pouch with tumour tissue, or dorsally with tumour tissue or tumour homogenate, obtained from tumours induced by chick embryo lethal orphan vi...

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Veröffentlicht in:Journal of general virology 1971-10, Vol.13 (1), p.121-126
Hauptverfasser: Mancini, L.O, Yates, V.J, Anderson, J, Jasty, V, Miller, L.T
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container_end_page 126
container_issue 1
container_start_page 121
container_title Journal of general virology
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creator Mancini, L.O
Yates, V.J
Anderson, J
Jasty, V
Miller, L.T
description Department of Animal Pathology, University of Rhode Island, Kingston, Rhode Island 02881, U.S.A. Weanling hamsters were inoculated subcutaneously in the cheek pouch with tumour tissue, or dorsally with tumour tissue or tumour homogenate, obtained from tumours induced by chick embryo lethal orphan virus. Hamsters 1 to 3 days old were inoculated subcutaneously in the dorsal region with chick embryo lethal orphan virus. Females were found to be more susceptible to tumour induction and required a lower dose of virus. There was no evidence of increased tumour resistance in hamsters up to 3 days old. Most neoplasms developed between the sixth and eighth month, usually at the site of virus deposition, although a few were noted in the following 2 months. All hamsters inoculated with transplants via the cheek pouch developed neoplasms. This incidence was well above that for tumours induced in the dorsal area. All neoplasms were well encapsulated fibrosarcomas regardless of the size of the tumour and type or site of inoculation. Most tumours were ‘kidney-shaped’, multilobulated, and of soft consistency. * Present address: Union Carbide Research Institute, Molecular Biology Laboratory, Tarrytown Technical Center, Tarrytown, New York 10591. Present address: Department of Oncology, Rhode Island Hospital, Providence, Rhode Island 02903. Received 21 December 1970; accepted 4 June 1971.
doi_str_mv 10.1099/0022-1317-13-1-121
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Weanling hamsters were inoculated subcutaneously in the cheek pouch with tumour tissue, or dorsally with tumour tissue or tumour homogenate, obtained from tumours induced by chick embryo lethal orphan virus. Hamsters 1 to 3 days old were inoculated subcutaneously in the dorsal region with chick embryo lethal orphan virus. Females were found to be more susceptible to tumour induction and required a lower dose of virus. There was no evidence of increased tumour resistance in hamsters up to 3 days old. Most neoplasms developed between the sixth and eighth month, usually at the site of virus deposition, although a few were noted in the following 2 months. All hamsters inoculated with transplants via the cheek pouch developed neoplasms. This incidence was well above that for tumours induced in the dorsal area. All neoplasms were well encapsulated fibrosarcomas regardless of the size of the tumour and type or site of inoculation. Most tumours were ‘kidney-shaped’, multilobulated, and of soft consistency. * Present address: Union Carbide Research Institute, Molecular Biology Laboratory, Tarrytown Technical Center, Tarrytown, New York 10591. Present address: Department of Oncology, Rhode Island Hospital, Providence, Rhode Island 02903. 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Most tumours were ‘kidney-shaped’, multilobulated, and of soft consistency. * Present address: Union Carbide Research Institute, Molecular Biology Laboratory, Tarrytown Technical Center, Tarrytown, New York 10591. Present address: Department of Oncology, Rhode Island Hospital, Providence, Rhode Island 02903. 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Weanling hamsters were inoculated subcutaneously in the cheek pouch with tumour tissue, or dorsally with tumour tissue or tumour homogenate, obtained from tumours induced by chick embryo lethal orphan virus. Hamsters 1 to 3 days old were inoculated subcutaneously in the dorsal region with chick embryo lethal orphan virus. Females were found to be more susceptible to tumour induction and required a lower dose of virus. There was no evidence of increased tumour resistance in hamsters up to 3 days old. Most neoplasms developed between the sixth and eighth month, usually at the site of virus deposition, although a few were noted in the following 2 months. All hamsters inoculated with transplants via the cheek pouch developed neoplasms. This incidence was well above that for tumours induced in the dorsal area. All neoplasms were well encapsulated fibrosarcomas regardless of the size of the tumour and type or site of inoculation. Most tumours were ‘kidney-shaped’, multilobulated, and of soft consistency. * Present address: Union Carbide Research Institute, Molecular Biology Laboratory, Tarrytown Technical Center, Tarrytown, New York 10591. Present address: Department of Oncology, Rhode Island Hospital, Providence, Rhode Island 02903. Received 21 December 1970; accepted 4 June 1971.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>4943304</pmid><doi>10.1099/0022-1317-13-1-121</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record>
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source MEDLINE; Microbiology Society; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection
subjects Adenoviridae - pathogenicity
Age Factors
animal diseases
animal health
Animals
Cricetinae
Female
Fibrosarcoma - epidemiology
Fibrosarcoma - etiology
Fibrosarcoma - pathology
Histological Techniques
Male
Neoplasm Transplantation
Neoplasms, Experimental - epidemiology
Neoplasms, Experimental - etiology
Neoplasms, Experimental - pathology
Sex Factors
title Tumour formation in hamsters inoculated with chick embryo lethal orphan virus
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