The effect of p-bromophenacylbromide, a phospholipase A inhibitor, in experimental acute pancreatitis in rats

In this study the effect of p-bromophenacylbromide (p-BPAB), an inhibitor of phospholipase A, was studied in acute pancreatitis in an experimental rat model. Acute pancreatitis was produced by instillation of 0.4 ml bile into the pancreatic duct. p-BPAB was injected i.p. in a dosage of 0.25 microgra...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Research in experimental medicine 1984, Vol.184 (3), p.179-189
Hauptverfasser: Zöch, G, Roth, E, Hölbling, N, Karner, J, Funovics, J, Czerwenka, K
Format: Artikel
Sprache:ger
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 189
container_issue 3
container_start_page 179
container_title Research in experimental medicine
container_volume 184
creator Zöch, G
Roth, E
Hölbling, N
Karner, J
Funovics, J
Czerwenka, K
description In this study the effect of p-bromophenacylbromide (p-BPAB), an inhibitor of phospholipase A, was studied in acute pancreatitis in an experimental rat model. Acute pancreatitis was produced by instillation of 0.4 ml bile into the pancreatic duct. p-BPAB was injected i.p. in a dosage of 0.25 micrograms/g b.wt. 30 min before, 30 min after, or 4h after the onset of pancreatitis. Prophylactic and early administration of p-BPAB inhibited severe morphological changes, such as necrosis and hemorrhages. Moreover, during administration of the inhibitor, decreased plasma concentrations of serum lipase and amylase (P less than 0.001) were monitored and compared with untreated animals. These therapeutic effects of p-BPAB were not seen in rats in which the inhibitor was injected 4 h after the onset of pancreatitis. As a result the phospholipase inhibitor, p-BPAB, reduces the clinical and morphological manifestations of acute pancreatitis. The effect of p-BPAB is dependent on the time of administration.
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_81227514</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>81227514</sourcerecordid><originalsourceid>FETCH-LOGICAL-p532-7a1dd7c04283cd473f04f18a3df43ae5180b28a4dd6c76d4a4fcd74793ecd9e3</originalsourceid><addsrcrecordid>eNotkM1qwzAQhHVoSdO0j1DQqacYJEu2nGMI_YNAD83drKUVVrEtVZKhefs6NIdhduBj2Z0bsmaCsWLHBbsj9yl9M8ZVrfiKrOqS1ZUo12Q89UjRWtSZektD0UU_-tDjBPo8XIIzuKVAQ-_TosEFSEj31E2961z2cbuMFH8DRjfilGGgoOeMNMCkI0J22aULEiGnB3JrYUj4ePUN-Xp9OR3ei-Pn28dhfyzCclShgBujNJNlI7SRSlgmLW9AGCsFYMUb1pUNSGNqrWojQVptlFQ7gdrsUGzI8__WEP3PjCm3o0sahwEm9HNqG16WquJyAZ-u4NyNaNqwvADx3F7bEX_VsWHP</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81227514</pqid></control><display><type>article</type><title>The effect of p-bromophenacylbromide, a phospholipase A inhibitor, in experimental acute pancreatitis in rats</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Zöch, G ; Roth, E ; Hölbling, N ; Karner, J ; Funovics, J ; Czerwenka, K</creator><creatorcontrib>Zöch, G ; Roth, E ; Hölbling, N ; Karner, J ; Funovics, J ; Czerwenka, K</creatorcontrib><description>In this study the effect of p-bromophenacylbromide (p-BPAB), an inhibitor of phospholipase A, was studied in acute pancreatitis in an experimental rat model. Acute pancreatitis was produced by instillation of 0.4 ml bile into the pancreatic duct. p-BPAB was injected i.p. in a dosage of 0.25 micrograms/g b.wt. 30 min before, 30 min after, or 4h after the onset of pancreatitis. Prophylactic and early administration of p-BPAB inhibited severe morphological changes, such as necrosis and hemorrhages. Moreover, during administration of the inhibitor, decreased plasma concentrations of serum lipase and amylase (P less than 0.001) were monitored and compared with untreated animals. These therapeutic effects of p-BPAB were not seen in rats in which the inhibitor was injected 4 h after the onset of pancreatitis. As a result the phospholipase inhibitor, p-BPAB, reduces the clinical and morphological manifestations of acute pancreatitis. The effect of p-BPAB is dependent on the time of administration.</description><identifier>ISSN: 0300-9130</identifier><identifier>PMID: 6206532</identifier><language>ger</language><publisher>Germany</publisher><subject>Acetophenones - therapeutic use ; Acute Disease ; Amylases - blood ; Animals ; Lipase - blood ; Pancreatitis - drug therapy ; Pancreatitis - enzymology ; Pancreatitis - prevention &amp; control ; Phospholipases - antagonists &amp; inhibitors ; Phospholipases A - antagonists &amp; inhibitors ; Rats ; Rats, Inbred Strains</subject><ispartof>Research in experimental medicine, 1984, Vol.184 (3), p.179-189</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6206532$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zöch, G</creatorcontrib><creatorcontrib>Roth, E</creatorcontrib><creatorcontrib>Hölbling, N</creatorcontrib><creatorcontrib>Karner, J</creatorcontrib><creatorcontrib>Funovics, J</creatorcontrib><creatorcontrib>Czerwenka, K</creatorcontrib><title>The effect of p-bromophenacylbromide, a phospholipase A inhibitor, in experimental acute pancreatitis in rats</title><title>Research in experimental medicine</title><addtitle>Res Exp Med (Berl)</addtitle><description>In this study the effect of p-bromophenacylbromide (p-BPAB), an inhibitor of phospholipase A, was studied in acute pancreatitis in an experimental rat model. Acute pancreatitis was produced by instillation of 0.4 ml bile into the pancreatic duct. p-BPAB was injected i.p. in a dosage of 0.25 micrograms/g b.wt. 30 min before, 30 min after, or 4h after the onset of pancreatitis. Prophylactic and early administration of p-BPAB inhibited severe morphological changes, such as necrosis and hemorrhages. Moreover, during administration of the inhibitor, decreased plasma concentrations of serum lipase and amylase (P less than 0.001) were monitored and compared with untreated animals. These therapeutic effects of p-BPAB were not seen in rats in which the inhibitor was injected 4 h after the onset of pancreatitis. As a result the phospholipase inhibitor, p-BPAB, reduces the clinical and morphological manifestations of acute pancreatitis. The effect of p-BPAB is dependent on the time of administration.</description><subject>Acetophenones - therapeutic use</subject><subject>Acute Disease</subject><subject>Amylases - blood</subject><subject>Animals</subject><subject>Lipase - blood</subject><subject>Pancreatitis - drug therapy</subject><subject>Pancreatitis - enzymology</subject><subject>Pancreatitis - prevention &amp; control</subject><subject>Phospholipases - antagonists &amp; inhibitors</subject><subject>Phospholipases A - antagonists &amp; inhibitors</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><issn>0300-9130</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNotkM1qwzAQhHVoSdO0j1DQqacYJEu2nGMI_YNAD83drKUVVrEtVZKhefs6NIdhduBj2Z0bsmaCsWLHBbsj9yl9M8ZVrfiKrOqS1ZUo12Q89UjRWtSZektD0UU_-tDjBPo8XIIzuKVAQ-_TosEFSEj31E2961z2cbuMFH8DRjfilGGgoOeMNMCkI0J22aULEiGnB3JrYUj4ePUN-Xp9OR3ei-Pn28dhfyzCclShgBujNJNlI7SRSlgmLW9AGCsFYMUb1pUNSGNqrWojQVptlFQ7gdrsUGzI8__WEP3PjCm3o0sahwEm9HNqG16WquJyAZ-u4NyNaNqwvADx3F7bEX_VsWHP</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Zöch, G</creator><creator>Roth, E</creator><creator>Hölbling, N</creator><creator>Karner, J</creator><creator>Funovics, J</creator><creator>Czerwenka, K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>The effect of p-bromophenacylbromide, a phospholipase A inhibitor, in experimental acute pancreatitis in rats</title><author>Zöch, G ; Roth, E ; Hölbling, N ; Karner, J ; Funovics, J ; Czerwenka, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p532-7a1dd7c04283cd473f04f18a3df43ae5180b28a4dd6c76d4a4fcd74793ecd9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>ger</language><creationdate>1984</creationdate><topic>Acetophenones - therapeutic use</topic><topic>Acute Disease</topic><topic>Amylases - blood</topic><topic>Animals</topic><topic>Lipase - blood</topic><topic>Pancreatitis - drug therapy</topic><topic>Pancreatitis - enzymology</topic><topic>Pancreatitis - prevention &amp; control</topic><topic>Phospholipases - antagonists &amp; inhibitors</topic><topic>Phospholipases A - antagonists &amp; inhibitors</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zöch, G</creatorcontrib><creatorcontrib>Roth, E</creatorcontrib><creatorcontrib>Hölbling, N</creatorcontrib><creatorcontrib>Karner, J</creatorcontrib><creatorcontrib>Funovics, J</creatorcontrib><creatorcontrib>Czerwenka, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Research in experimental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zöch, G</au><au>Roth, E</au><au>Hölbling, N</au><au>Karner, J</au><au>Funovics, J</au><au>Czerwenka, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of p-bromophenacylbromide, a phospholipase A inhibitor, in experimental acute pancreatitis in rats</atitle><jtitle>Research in experimental medicine</jtitle><addtitle>Res Exp Med (Berl)</addtitle><date>1984</date><risdate>1984</risdate><volume>184</volume><issue>3</issue><spage>179</spage><epage>189</epage><pages>179-189</pages><issn>0300-9130</issn><abstract>In this study the effect of p-bromophenacylbromide (p-BPAB), an inhibitor of phospholipase A, was studied in acute pancreatitis in an experimental rat model. Acute pancreatitis was produced by instillation of 0.4 ml bile into the pancreatic duct. p-BPAB was injected i.p. in a dosage of 0.25 micrograms/g b.wt. 30 min before, 30 min after, or 4h after the onset of pancreatitis. Prophylactic and early administration of p-BPAB inhibited severe morphological changes, such as necrosis and hemorrhages. Moreover, during administration of the inhibitor, decreased plasma concentrations of serum lipase and amylase (P less than 0.001) were monitored and compared with untreated animals. These therapeutic effects of p-BPAB were not seen in rats in which the inhibitor was injected 4 h after the onset of pancreatitis. As a result the phospholipase inhibitor, p-BPAB, reduces the clinical and morphological manifestations of acute pancreatitis. The effect of p-BPAB is dependent on the time of administration.</abstract><cop>Germany</cop><pmid>6206532</pmid><tpages>11</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0300-9130
ispartof Research in experimental medicine, 1984, Vol.184 (3), p.179-189
issn 0300-9130
language ger
recordid cdi_proquest_miscellaneous_81227514
source MEDLINE; Alma/SFX Local Collection
subjects Acetophenones - therapeutic use
Acute Disease
Amylases - blood
Animals
Lipase - blood
Pancreatitis - drug therapy
Pancreatitis - enzymology
Pancreatitis - prevention & control
Phospholipases - antagonists & inhibitors
Phospholipases A - antagonists & inhibitors
Rats
Rats, Inbred Strains
title The effect of p-bromophenacylbromide, a phospholipase A inhibitor, in experimental acute pancreatitis in rats
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T08%3A07%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20effect%20of%20p-bromophenacylbromide,%20a%20phospholipase%20A%20inhibitor,%20in%20experimental%20acute%20pancreatitis%20in%20rats&rft.jtitle=Research%20in%20experimental%20medicine&rft.au=Z%C3%B6ch,%20G&rft.date=1984&rft.volume=184&rft.issue=3&rft.spage=179&rft.epage=189&rft.pages=179-189&rft.issn=0300-9130&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E81227514%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81227514&rft_id=info:pmid/6206532&rfr_iscdi=true