Evaluation of the beta-carboline ZK 93 426 as a benzodiazepine receptor antagonist

We describe here biochemical and pharmacological effects of the beta-carboline ZK 93426 was compared with Ro 15-1788 and CGS 8216, two compounds previously described as BZ receptor antagonists. Certain effects of ZK 93426, Ro 15-1788 and CGS 8216 were quite similar (e.g., 3H-FNM displacement, "...

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Veröffentlicht in:	Psychopharmacology 1984, Vol.83 (3), p.249-256
Hauptverfasser:	Jensen, L H, Petersen, E N, Braestrup, C, Honoré, T, Kehr, W, Stephens, D N, Schneider, H, Seidelmann, D, Schmiechen, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticonvulsants - pharmacology Ataxia - drug therapy Benzodiazepinones - pharmacology Binding, Competitive Carbolines - antagonists & inhibitors Carbolines - pharmacology Diazepam - pharmacology Discrimination (Psychology) - drug effects Drinking - drug effects Exploratory Behavior - drug effects Flumazenil gamma-Aminobutyric Acid - metabolism In Vitro Techniques Indoles - pharmacology Mice Pyrazoles - pharmacology Rats Rats, Inbred Strains Receptors, Cell Surface - antagonists & inhibitors Receptors, GABA-A Receptors, Neurotransmitter - drug effects Sleep - drug effects
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