Glucostatic modulation of the hypothalamus by phenformin

Phenformin, an oral anti-diabetic biguanide, diminished lateral hypothalamic self-stimulation in rats and restored ventromedial hypothalamus vulnerability to gold thioglucose in diabetic mice. Those effects were independent of hypoglycemia or general locomotor activity depression. This indicated tha...

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Veröffentlicht in:	Physiology & behavior 1971-12, Vol.7 (6), p.807,IN1,809-808,IN2,810
Hauptverfasser:	Briese, E., Rondon Morales, R., Hernandez, L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidiabetic drugs Blood Glucose - metabolism Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Electrodes, Implanted Glucose - metabolism Glucose - pharmacology Glucose Tolerance Test Glucostatic theory Gold - pharmacology Gold thioglucose Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Insulin Male Phenformin Phenformin - pharmacology Rats Self Stimulation - drug effects Self-stimulation
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