Glucostatic modulation of the hypothalamus by phenformin
Phenformin, an oral anti-diabetic biguanide, diminished lateral hypothalamic self-stimulation in rats and restored ventromedial hypothalamus vulnerability to gold thioglucose in diabetic mice. Those effects were independent of hypoglycemia or general locomotor activity depression. This indicated tha...
Gespeichert in:
| Veröffentlicht in: | Physiology & behavior 1971-12, Vol.7 (6), p.807,IN1,809-808,IN2,810 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 808,IN2,810 |
|---|---|
| container_issue | 6 |
| container_start_page | 807,IN1,809 |
| container_title | Physiology & behavior |
| container_volume | 7 |
| creator | Briese, E. Rondon Morales, R. Hernandez, L. |
| description | Phenformin, an oral anti-diabetic biguanide, diminished lateral hypothalamic self-stimulation in rats and restored ventromedial hypothalamus vulnerability to gold thioglucose in diabetic mice. Those effects were independent of hypoglycemia or general locomotor activity depression. This indicated that phenformin, the same as insulin, facilitates transport and metabolism of glucose into the ventromedial hypothalamic region, and in this way, modulated the inhibitory tone this area exerts on the lateral hypothalamus. |
| doi_str_mv | 10.1016/0031-9384(71)90043-6 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81225038</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>0031938471900436</els_id><sourcerecordid>81225038</sourcerecordid><originalsourceid>FETCH-LOGICAL-c357t-a4a1c98343bd00a732730d40ee0f6208a61ee84b35c050af189fe00a20f9e5033</originalsourceid><addsrcrecordid>eNp9kE1LxDAQQIMo67r6DxR6Ej1UJ03aphdBFr9gwYuCt5CmE1ppm5q0wv57U3bZo3OZgXkzwzxCLincUaDZPQCjccEEv8npbQHAWZwdkSUVOYtTyL-OyfKAnJIz778hBONsQRYpZRyoWBLx0k7a-lGNjY46W01tqGwfWRONNUb1drBjrVrVTT4qt9FQY2-s65r-nJwY1Xq82OcV-Xx--li_xpv3l7f14ybWLM3HWHFFdSHC1bICUDlLcgYVB0QwWQJCZRRR8JKlGlJQhorCYAATMAWmwNiKXO_2Ds7-TOhH2TVeY9uqHu3kpaBJEjgRQL4DtbPeOzRycE2n3FZSkLMwOduQsw2ZhzwLk1kYu9rvn8oOq8PQ3lDoP-z6GJ78bdBJrxvsNVaNQz3Kyjb_H_gDdDB5LQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81225038</pqid></control><display><type>article</type><title>Glucostatic modulation of the hypothalamus by phenformin</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Briese, E. ; Rondon Morales, R. ; Hernandez, L.</creator><creatorcontrib>Briese, E. ; Rondon Morales, R. ; Hernandez, L.</creatorcontrib><description>Phenformin, an oral anti-diabetic biguanide, diminished lateral hypothalamic self-stimulation in rats and restored ventromedial hypothalamus vulnerability to gold thioglucose in diabetic mice. Those effects were independent of hypoglycemia or general locomotor activity depression. This indicated that phenformin, the same as insulin, facilitates transport and metabolism of glucose into the ventromedial hypothalamic region, and in this way, modulated the inhibitory tone this area exerts on the lateral hypothalamus.</description><identifier>ISSN: 0031-9384</identifier><identifier>EISSN: 1873-507X</identifier><identifier>DOI: 10.1016/0031-9384(71)90043-6</identifier><identifier>PMID: 5134018</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Antidiabetic drugs ; Blood Glucose - metabolism ; Diabetes mellitus ; Diabetes Mellitus, Experimental - metabolism ; Electrodes, Implanted ; Glucose - metabolism ; Glucose - pharmacology ; Glucose Tolerance Test ; Glucostatic theory ; Gold - pharmacology ; Gold thioglucose ; Hypothalamus ; Hypothalamus - drug effects ; Hypothalamus - metabolism ; Insulin ; Male ; Phenformin ; Phenformin - pharmacology ; Rats ; Self Stimulation - drug effects ; Self-stimulation</subject><ispartof>Physiology & behavior, 1971-12, Vol.7 (6), p.807,IN1,809-808,IN2,810</ispartof><rights>1971</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-a4a1c98343bd00a732730d40ee0f6208a61ee84b35c050af189fe00a20f9e5033</citedby><cites>FETCH-LOGICAL-c357t-a4a1c98343bd00a732730d40ee0f6208a61ee84b35c050af189fe00a20f9e5033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0031938471900436$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5134018$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Briese, E.</creatorcontrib><creatorcontrib>Rondon Morales, R.</creatorcontrib><creatorcontrib>Hernandez, L.</creatorcontrib><title>Glucostatic modulation of the hypothalamus by phenformin</title><title>Physiology & behavior</title><addtitle>Physiol Behav</addtitle><description>Phenformin, an oral anti-diabetic biguanide, diminished lateral hypothalamic self-stimulation in rats and restored ventromedial hypothalamus vulnerability to gold thioglucose in diabetic mice. Those effects were independent of hypoglycemia or general locomotor activity depression. This indicated that phenformin, the same as insulin, facilitates transport and metabolism of glucose into the ventromedial hypothalamic region, and in this way, modulated the inhibitory tone this area exerts on the lateral hypothalamus.</description><subject>Animals</subject><subject>Antidiabetic drugs</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Electrodes, Implanted</subject><subject>Glucose - metabolism</subject><subject>Glucose - pharmacology</subject><subject>Glucose Tolerance Test</subject><subject>Glucostatic theory</subject><subject>Gold - pharmacology</subject><subject>Gold thioglucose</subject><subject>Hypothalamus</subject><subject>Hypothalamus - drug effects</subject><subject>Hypothalamus - metabolism</subject><subject>Insulin</subject><subject>Male</subject><subject>Phenformin</subject><subject>Phenformin - pharmacology</subject><subject>Rats</subject><subject>Self Stimulation - drug effects</subject><subject>Self-stimulation</subject><issn>0031-9384</issn><issn>1873-507X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQQIMo67r6DxR6Ej1UJ03aphdBFr9gwYuCt5CmE1ppm5q0wv57U3bZo3OZgXkzwzxCLincUaDZPQCjccEEv8npbQHAWZwdkSUVOYtTyL-OyfKAnJIz778hBONsQRYpZRyoWBLx0k7a-lGNjY46W01tqGwfWRONNUb1drBjrVrVTT4qt9FQY2-s65r-nJwY1Xq82OcV-Xx--li_xpv3l7f14ybWLM3HWHFFdSHC1bICUDlLcgYVB0QwWQJCZRRR8JKlGlJQhorCYAATMAWmwNiKXO_2Ds7-TOhH2TVeY9uqHu3kpaBJEjgRQL4DtbPeOzRycE2n3FZSkLMwOduQsw2ZhzwLk1kYu9rvn8oOq8PQ3lDoP-z6GJ78bdBJrxvsNVaNQz3Kyjb_H_gDdDB5LQ</recordid><startdate>197112</startdate><enddate>197112</enddate><creator>Briese, E.</creator><creator>Rondon Morales, R.</creator><creator>Hernandez, L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197112</creationdate><title>Glucostatic modulation of the hypothalamus by phenformin</title><author>Briese, E. ; Rondon Morales, R. ; Hernandez, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-a4a1c98343bd00a732730d40ee0f6208a61ee84b35c050af189fe00a20f9e5033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Antidiabetic drugs</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Electrodes, Implanted</topic><topic>Glucose - metabolism</topic><topic>Glucose - pharmacology</topic><topic>Glucose Tolerance Test</topic><topic>Glucostatic theory</topic><topic>Gold - pharmacology</topic><topic>Gold thioglucose</topic><topic>Hypothalamus</topic><topic>Hypothalamus - drug effects</topic><topic>Hypothalamus - metabolism</topic><topic>Insulin</topic><topic>Male</topic><topic>Phenformin</topic><topic>Phenformin - pharmacology</topic><topic>Rats</topic><topic>Self Stimulation - drug effects</topic><topic>Self-stimulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Briese, E.</creatorcontrib><creatorcontrib>Rondon Morales, R.</creatorcontrib><creatorcontrib>Hernandez, L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiology & behavior</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Briese, E.</au><au>Rondon Morales, R.</au><au>Hernandez, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Glucostatic modulation of the hypothalamus by phenformin</atitle><jtitle>Physiology & behavior</jtitle><addtitle>Physiol Behav</addtitle><date>1971-12</date><risdate>1971</risdate><volume>7</volume><issue>6</issue><spage>807,IN1,809</spage><epage>808,IN2,810</epage><pages>807,IN1,809-808,IN2,810</pages><issn>0031-9384</issn><eissn>1873-507X</eissn><abstract>Phenformin, an oral anti-diabetic biguanide, diminished lateral hypothalamic self-stimulation in rats and restored ventromedial hypothalamus vulnerability to gold thioglucose in diabetic mice. Those effects were independent of hypoglycemia or general locomotor activity depression. This indicated that phenformin, the same as insulin, facilitates transport and metabolism of glucose into the ventromedial hypothalamic region, and in this way, modulated the inhibitory tone this area exerts on the lateral hypothalamus.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5134018</pmid><doi>10.1016/0031-9384(71)90043-6</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-9384 |
| ispartof | Physiology & behavior, 1971-12, Vol.7 (6), p.807,IN1,809-808,IN2,810 |
| issn | 0031-9384 1873-507X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81225038 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antidiabetic drugs Blood Glucose - metabolism Diabetes mellitus Diabetes Mellitus, Experimental - metabolism Electrodes, Implanted Glucose - metabolism Glucose - pharmacology Glucose Tolerance Test Glucostatic theory Gold - pharmacology Gold thioglucose Hypothalamus Hypothalamus - drug effects Hypothalamus - metabolism Insulin Male Phenformin Phenformin - pharmacology Rats Self Stimulation - drug effects Self-stimulation |
| title | Glucostatic modulation of the hypothalamus by phenformin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-26T14%3A03%3A24IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Glucostatic%20modulation%20of%20the%20hypothalamus%20by%20phenformin&rft.jtitle=Physiology%20&%20behavior&rft.au=Briese,%20E.&rft.date=1971-12&rft.volume=7&rft.issue=6&rft.spage=807,IN1,809&rft.epage=808,IN2,810&rft.pages=807,IN1,809-808,IN2,810&rft.issn=0031-9384&rft.eissn=1873-507X&rft_id=info:doi/10.1016/0031-9384(71)90043-6&rft_dat=%3Cproquest_cross%3E81225038%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81225038&rft_id=info:pmid/5134018&rft_els_id=0031938471900436&rfr_iscdi=true |