Novel amino-substituted 3-quinolinecarboxylic acid antibacterial agents: synthesis and structure-activity relationships

A series of novel 3-quinolinecarboxylic acid derivatives have been prepared and their antibacterial activity evaluated. These derivatives are characterized by fluorine attached to the 6-position and substituted amino groups appended to the 1- and 7-positions. Structure-activity relationship studies...

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Veröffentlicht in:	Journal of medicinal chemistry 1984-09, Vol.27 (9), p.1103-1108
Hauptverfasser:	Wentland, Mark P, Bailey, Denis M, Cornett, James B, Dobson, Richard A, Powles, Ronald G, Wagner, Roland B
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents Chemistry Escherichia coli Escherichia coli - drug effects Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with several n hetero atoms in the same ring, in separated rings or in fused rings Organic chemistry Preparations and properties Quinolines - chemical synthesis Quinolines - pharmacology Structure-Activity Relationship
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