Synthesis and antihypertensive activity of 6,7-disubstituted trans-4-amino-3,4-dihydro-2,2-dimethyl-2H-1-benzopyran-3-ols

A series of novel 6,7-disubstituted trans-3,4-dihydro-2, 2-dimethyl-4-pyrrolidino-(or piperidino)-2H-1-benzopyran-3-ols was prepared and tested for antihypertensive activity in the conscious spontaneously hypertensive rat (SHR) and compared with certain of their monosubstituted analogues. The potent...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of medicinal chemistry 1984-09, Vol.27 (9), p.1127-1131
Hauptverfasser:	Evans, John M, Fake, Charles S, Hamilton, Thomas C, Poyser, Robert H, Showell, Graham A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antihypertensive Agents - chemical synthesis Benzopyrans - chemical synthesis Benzopyrans - therapeutic use Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Organic chemistry Piperidines - chemical synthesis Piperidines - therapeutic use Preparations and properties Rats Rats, Mutant Strains Structure-Activity Relationship
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!