Prostaglandin release and nociceptor stimulation by peptides
The effects of substance P, somatostatin, vasoactive intestinal polypeptide, cholecystokinin octapeptide, eledoisin and bombesin on release and metabolism of incorporated (1-14C)-arachidonic acid was investigated in the isolated rabbit ear. The influence of eledoisin and bombesin on release of prost...
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| Veröffentlicht in: | Naunyn-Schmiedeberg's archives of pharmacology 1984-05, Vol.326 (1), p.64-68 |
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| container_title | Naunyn-Schmiedeberg's archives of pharmacology |
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| creator | JUAN, H SAMETZ, W PETRONIJEVIC, S LEMBECK, F |
| description | The effects of substance P, somatostatin, vasoactive intestinal polypeptide, cholecystokinin octapeptide, eledoisin and bombesin on release and metabolism of incorporated (1-14C)-arachidonic acid was investigated in the isolated rabbit ear. The influence of eledoisin and bombesin on release of prostaglandins was compared with that of bradykinin (Sametz and Juan 1982). Only eledoisin and bombesin stimulated the release of prostaglandins I2 and E2 but with a lesser potency than bradykinin. Only eledoisin in a high dose stimulated nociceptors per se whereas bombesin did not. Eledoisin and bombesin in a low dose enhanced nocicpetion induced by acetylcholine in the rabbit ear; this enhancement of the algesic effect of acetylcholine was abolished by indometacin which indicates a sensitization of nociceptors by released prostaglandins. Although effects of eledoisin and bombesin are mediated at least in part by released prostaglandins, the nociceptor-stimulating and prostaglandin-releasing potency of bradykinin remaines unique among all peptides tested so far. |
| doi_str_mv | 10.1007/BF00518780 |
| format | Article |
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The influence of eledoisin and bombesin on release of prostaglandins was compared with that of bradykinin (Sametz and Juan 1982). Only eledoisin and bombesin stimulated the release of prostaglandins I2 and E2 but with a lesser potency than bradykinin. Only eledoisin in a high dose stimulated nociceptors per se whereas bombesin did not. Eledoisin and bombesin in a low dose enhanced nocicpetion induced by acetylcholine in the rabbit ear; this enhancement of the algesic effect of acetylcholine was abolished by indometacin which indicates a sensitization of nociceptors by released prostaglandins. Although effects of eledoisin and bombesin are mediated at least in part by released prostaglandins, the nociceptor-stimulating and prostaglandin-releasing potency of bradykinin remaines unique among all peptides tested so far.</description><identifier>ISSN: 0028-1298</identifier><identifier>EISSN: 1432-1912</identifier><identifier>DOI: 10.1007/BF00518780</identifier><identifier>PMID: 6088999</identifier><identifier>CODEN: NSAPCC</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Arachidonic Acid ; Arachidonic Acids - metabolism ; Biological and medical sciences ; Blood Pressure - drug effects ; Bombesin - pharmacology ; Eledoisin - pharmacology ; Fundamental and applied biological sciences. Psychology ; In Vitro Techniques ; Nociceptors - drug effects ; Nociceptors - metabolism ; Peptides - pharmacology ; Prostaglandins - biosynthesis ; Prostaglandins - metabolism ; Rabbits ; Sincalide - pharmacology ; Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. 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The influence of eledoisin and bombesin on release of prostaglandins was compared with that of bradykinin (Sametz and Juan 1982). Only eledoisin and bombesin stimulated the release of prostaglandins I2 and E2 but with a lesser potency than bradykinin. Only eledoisin in a high dose stimulated nociceptors per se whereas bombesin did not. Eledoisin and bombesin in a low dose enhanced nocicpetion induced by acetylcholine in the rabbit ear; this enhancement of the algesic effect of acetylcholine was abolished by indometacin which indicates a sensitization of nociceptors by released prostaglandins. Although effects of eledoisin and bombesin are mediated at least in part by released prostaglandins, the nociceptor-stimulating and prostaglandin-releasing potency of bradykinin remaines unique among all peptides tested so far.</description><subject>Animals</subject><subject>Arachidonic Acid</subject><subject>Arachidonic Acids - metabolism</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Bombesin - pharmacology</subject><subject>Eledoisin - pharmacology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>In Vitro Techniques</subject><subject>Nociceptors - drug effects</subject><subject>Nociceptors - metabolism</subject><subject>Peptides - pharmacology</subject><subject>Prostaglandins - biosynthesis</subject><subject>Prostaglandins - metabolism</subject><subject>Rabbits</subject><subject>Sincalide - pharmacology</subject><subject>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. 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Psychology</topic><topic>In Vitro Techniques</topic><topic>Nociceptors - drug effects</topic><topic>Nociceptors - metabolism</topic><topic>Peptides - pharmacology</topic><topic>Prostaglandins - biosynthesis</topic><topic>Prostaglandins - metabolism</topic><topic>Rabbits</topic><topic>Sincalide - pharmacology</topic><topic>Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>JUAN, H</creatorcontrib><creatorcontrib>SAMETZ, W</creatorcontrib><creatorcontrib>PETRONIJEVIC, S</creatorcontrib><creatorcontrib>LEMBECK, F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>JUAN, H</au><au>SAMETZ, W</au><au>PETRONIJEVIC, S</au><au>LEMBECK, F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostaglandin release and nociceptor stimulation by peptides</atitle><jtitle>Naunyn-Schmiedeberg's archives of pharmacology</jtitle><addtitle>Naunyn Schmiedebergs Arch Pharmacol</addtitle><date>1984-05</date><risdate>1984</risdate><volume>326</volume><issue>1</issue><spage>64</spage><epage>68</epage><pages>64-68</pages><issn>0028-1298</issn><eissn>1432-1912</eissn><coden>NSAPCC</coden><abstract>The effects of substance P, somatostatin, vasoactive intestinal polypeptide, cholecystokinin octapeptide, eledoisin and bombesin on release and metabolism of incorporated (1-14C)-arachidonic acid was investigated in the isolated rabbit ear. The influence of eledoisin and bombesin on release of prostaglandins was compared with that of bradykinin (Sametz and Juan 1982). Only eledoisin and bombesin stimulated the release of prostaglandins I2 and E2 but with a lesser potency than bradykinin. Only eledoisin in a high dose stimulated nociceptors per se whereas bombesin did not. Eledoisin and bombesin in a low dose enhanced nocicpetion induced by acetylcholine in the rabbit ear; this enhancement of the algesic effect of acetylcholine was abolished by indometacin which indicates a sensitization of nociceptors by released prostaglandins. 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| ispartof | Naunyn-Schmiedeberg's archives of pharmacology, 1984-05, Vol.326 (1), p.64-68 |
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| language | eng |
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| source | MEDLINE; SpringerNature Complete Journals |
| subjects | Animals Arachidonic Acid Arachidonic Acids - metabolism Biological and medical sciences Blood Pressure - drug effects Bombesin - pharmacology Eledoisin - pharmacology Fundamental and applied biological sciences. Psychology In Vitro Techniques Nociceptors - drug effects Nociceptors - metabolism Peptides - pharmacology Prostaglandins - biosynthesis Prostaglandins - metabolism Rabbits Sincalide - pharmacology Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Vertebrates: nervous system and sense organs |
| title | Prostaglandin release and nociceptor stimulation by peptides |
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