Does clofibrate mobilize cholesterol from tissues?
Previous work by the authors (1) showed that in the high-lipid-fed rat, clofibrate (CPIB) lowered the deposition of cholesterol in the aorta and kidney. The possibility was raised that CPIB might mobilize cholesterol from these organs. This possibility was also raised by Tolman et al. (2) in their p...
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| Veröffentlicht in: | Biochemical medicine 1971-04, Vol.5 (2), p.165-172 |
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| container_title | Biochemical medicine |
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| creator | Rothfeld, B. Karmen, A. Hunter, C.F. Varady, A. |
| description | Previous work by the authors (1) showed that in the high-lipid-fed rat, clofibrate (CPIB) lowered the deposition of cholesterol in the aorta and kidney. The possibility was raised that CPIB might mobilize cholesterol from these organs. This possibility was also raised by Tolman
et al. (2) in their paper. Kritchevsky
et al. (3) raised another possible explanation for the production of lower tissue cholesterol levels produced by CPIB when they showed that mitrochondria from CPIB-fed rats had an increased ability to oxidize labeled cholesterol
in vitro.
In the following experiment an attempt was made to prove or disprove the thesis that CPIB had a cholesterol mobilizing effect from tissue. |
| doi_str_mv | 10.1016/0006-2944(71)90084-6 |
| format | Article |
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et al. (2) in their paper. Kritchevsky
et al. (3) raised another possible explanation for the production of lower tissue cholesterol levels produced by CPIB when they showed that mitrochondria from CPIB-fed rats had an increased ability to oxidize labeled cholesterol
in vitro.
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et al. (2) in their paper. Kritchevsky
et al. (3) raised another possible explanation for the production of lower tissue cholesterol levels produced by CPIB when they showed that mitrochondria from CPIB-fed rats had an increased ability to oxidize labeled cholesterol
in vitro.
In the following experiment an attempt was made to prove or disprove the thesis that CPIB had a cholesterol mobilizing effect from tissue.</description><subject>Animals</subject><subject>Aorta - drug effects</subject><subject>Aorta - metabolism</subject><subject>Carbon Isotopes</subject><subject>Cholesterol - biosynthesis</subject><subject>Cholesterol - blood</subject><subject>Cholesterol - metabolism</subject><subject>Clofibrate - pharmacology</subject><subject>Dietary Fats</subject><subject>Fasting</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Mathematics</subject><subject>Metabolism - drug effects</subject><subject>Rats</subject><subject>Statistics as Topic</subject><issn>0006-2944</issn><issn>1557-7996</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLAzEQx4MotVa_gcKeRA-rk8dmdy-K1CcUvOg5pMkEI7uNJltBP72pLT16Gpj5P5gfIccULihQeQkAsmStEGc1PW8BGlHKHTKmVVWXddvKXTLeSvbJQUrvAKwRgo7IqKKcigrGhN0GTIXpgvPzqAcs-jD3nf_BwryFDtOAMXSFi6EvBp_SEtP1Idlzukt4tJkT8np_9zJ9LGfPD0_Tm1lpeFUPpeWU6bYBTVvQ4IQDbAwwI6k0vOFoddPmheNctpY5B8LOs0dY4EyKrJiQ03XuRwyfuXhQvU8Gu04vMCyTaihjTDCehWItNDGkFNGpj-h7Hb8VBbVCpVYc1IqDqqn6Q6Vktp1s8pfzHu3WtGGT71frO-YnvzxGlYzHhUHrI5pB2eD_L_gFrgN2qw</recordid><startdate>197104</startdate><enddate>197104</enddate><creator>Rothfeld, B.</creator><creator>Karmen, A.</creator><creator>Hunter, C.F.</creator><creator>Varady, A.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197104</creationdate><title>Does clofibrate mobilize cholesterol from tissues?</title><author>Rothfeld, B. ; Karmen, A. ; Hunter, C.F. ; Varady, A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-d312a980a190a0f4f0e8c02c616c383eda898c0f3369d2ff04dbd314d03264383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Animals</topic><topic>Aorta - drug effects</topic><topic>Aorta - metabolism</topic><topic>Carbon Isotopes</topic><topic>Cholesterol - biosynthesis</topic><topic>Cholesterol - blood</topic><topic>Cholesterol - metabolism</topic><topic>Clofibrate - pharmacology</topic><topic>Dietary Fats</topic><topic>Fasting</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Mathematics</topic><topic>Metabolism - drug effects</topic><topic>Rats</topic><topic>Statistics as Topic</topic><toplevel>online_resources</toplevel><creatorcontrib>Rothfeld, B.</creatorcontrib><creatorcontrib>Karmen, A.</creatorcontrib><creatorcontrib>Hunter, C.F.</creatorcontrib><creatorcontrib>Varady, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rothfeld, B.</au><au>Karmen, A.</au><au>Hunter, C.F.</au><au>Varady, A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does clofibrate mobilize cholesterol from tissues?</atitle><jtitle>Biochemical medicine</jtitle><addtitle>Biochem Med</addtitle><date>1971-04</date><risdate>1971</risdate><volume>5</volume><issue>2</issue><spage>165</spage><epage>172</epage><pages>165-172</pages><issn>0006-2944</issn><eissn>1557-7996</eissn><abstract>Previous work by the authors (1) showed that in the high-lipid-fed rat, clofibrate (CPIB) lowered the deposition of cholesterol in the aorta and kidney. The possibility was raised that CPIB might mobilize cholesterol from these organs. This possibility was also raised by Tolman
et al. (2) in their paper. Kritchevsky
et al. (3) raised another possible explanation for the production of lower tissue cholesterol levels produced by CPIB when they showed that mitrochondria from CPIB-fed rats had an increased ability to oxidize labeled cholesterol
in vitro.
In the following experiment an attempt was made to prove or disprove the thesis that CPIB had a cholesterol mobilizing effect from tissue.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>5131450</pmid><doi>10.1016/0006-2944(71)90084-6</doi><tpages>8</tpages></addata></record> |
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| ispartof | Biochemical medicine, 1971-04, Vol.5 (2), p.165-172 |
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| language | eng |
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| subjects | Animals Aorta - drug effects Aorta - metabolism Carbon Isotopes Cholesterol - biosynthesis Cholesterol - blood Cholesterol - metabolism Clofibrate - pharmacology Dietary Fats Fasting Kidney - drug effects Kidney - metabolism Liver - drug effects Liver - metabolism Mathematics Metabolism - drug effects Rats Statistics as Topic |
| title | Does clofibrate mobilize cholesterol from tissues? |
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