Metabolism of androgens by isolated human beard hair follicles
Human beard hair follicles were incubated in vitro with testosterone-7- 3H, androstenedione-1,2- 3H and dehydroepiandrosterone-4- 14C.The principal metabolites of testosterone were androstenedione, 5α-androstanedione, 5α-dihydrotestosterone and androsterone. The conversion of androstenedione into te...
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| Veröffentlicht in: | Steroids 1971-01, Vol.18 (4), p.367-379 |
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| creator | Fazekas, Arpad G. Lanthier, André |
| description | Human beard hair follicles were incubated
in vitro
with testosterone-7-
3H, androstenedione-1,2-
3H and dehydroepiandrosterone-4-
14C.The principal metabolites of testosterone were androstenedione, 5α-androstanedione, 5α-dihydrotestosterone and androsterone. The conversion of androstenedione into testosterone and 5α-dihydrotestosterone was very limited. Dehydroepiandrosterone was metabolized to 5-androstene-3β,17β-diol, 7α-hydroxy-dehydroepiandrosterone and androstenedione, with rates of formation far exceeding those reported for human skin. The significance of these metabolic transformations is discussed with special reference to the mechanism of action of androgens. |
| doi_str_mv | 10.1016/0039-128X(71)90051-1 |
| format | Article |
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in vitro
with testosterone-7-
3H, androstenedione-1,2-
3H and dehydroepiandrosterone-4-
14C.The principal metabolites of testosterone were androstenedione, 5α-androstanedione, 5α-dihydrotestosterone and androsterone. The conversion of androstenedione into testosterone and 5α-dihydrotestosterone was very limited. Dehydroepiandrosterone was metabolized to 5-androstene-3β,17β-diol, 7α-hydroxy-dehydroepiandrosterone and androstenedione, with rates of formation far exceeding those reported for human skin. The significance of these metabolic transformations is discussed with special reference to the mechanism of action of androgens.</description><identifier>ISSN: 0039-128X</identifier><identifier>EISSN: 1878-5867</identifier><identifier>DOI: 10.1016/0039-128X(71)90051-1</identifier><identifier>PMID: 4257277</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Alcohols - biosynthesis ; Androgens - metabolism ; Androstanes - biosynthesis ; Androstanes - metabolism ; Androsterone - biosynthesis ; Chromatography, Paper ; Chromatography, Thin Layer ; Dehydroepiandrosterone - metabolism ; Female ; Hair - anatomy & histology ; Hair - metabolism ; Hirsutism - metabolism ; Humans ; Ketosteroids - biosynthesis ; Ketosteroids - metabolism ; Male ; Testosterone - biosynthesis ; Testosterone - metabolism ; Tritium</subject><ispartof>Steroids, 1971-01, Vol.18 (4), p.367-379</ispartof><rights>1971</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-f9d585df1d8345504acb9d23fe7e1b480c32d86da7d18dfb66621e50d295a4b13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0039-128X(71)90051-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,778,782,3539,27911,27912,45982</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4257277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fazekas, Arpad G.</creatorcontrib><creatorcontrib>Lanthier, André</creatorcontrib><title>Metabolism of androgens by isolated human beard hair follicles</title><title>Steroids</title><addtitle>Steroids</addtitle><description>Human beard hair follicles were incubated
in vitro
with testosterone-7-
3H, androstenedione-1,2-
3H and dehydroepiandrosterone-4-
14C.The principal metabolites of testosterone were androstenedione, 5α-androstanedione, 5α-dihydrotestosterone and androsterone. The conversion of androstenedione into testosterone and 5α-dihydrotestosterone was very limited. Dehydroepiandrosterone was metabolized to 5-androstene-3β,17β-diol, 7α-hydroxy-dehydroepiandrosterone and androstenedione, with rates of formation far exceeding those reported for human skin. The significance of these metabolic transformations is discussed with special reference to the mechanism of action of androgens.</description><subject>Adult</subject><subject>Alcohols - biosynthesis</subject><subject>Androgens - metabolism</subject><subject>Androstanes - biosynthesis</subject><subject>Androstanes - metabolism</subject><subject>Androsterone - biosynthesis</subject><subject>Chromatography, Paper</subject><subject>Chromatography, Thin Layer</subject><subject>Dehydroepiandrosterone - metabolism</subject><subject>Female</subject><subject>Hair - anatomy & histology</subject><subject>Hair - metabolism</subject><subject>Hirsutism - metabolism</subject><subject>Humans</subject><subject>Ketosteroids - biosynthesis</subject><subject>Ketosteroids - metabolism</subject><subject>Male</subject><subject>Testosterone - biosynthesis</subject><subject>Testosterone - metabolism</subject><subject>Tritium</subject><issn>0039-128X</issn><issn>1878-5867</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRR6Ej1UM2nTpBdBFv_BihcFbyFNphppmzVphf32dt1lj55m4L15w_sRcgr0CigU15RmZQpMvl8IuCwp5ZDCHpmCFDLlshD7ZLqzHJKjGL8opUVWsgmZ5IwLJsSU3DxjryvfuNgmvk50Z4P_wC4m1Spx0Te6R5t8Dq3ukgp1GHftQlL7pnGmwXhMDmrdRDzZzhl5u797nT-mi5eHp_ntIjU5Z31al5ZLbmuwMss5p7k2VWlZVqNAqHJJTcasLKwWFqStq6IoGCCnlpVc5xVkM3K-yV0G_z1g7FXrosGm0R36ISoJjEHJ2GjMN0YTfIwBa7UMrtVhpYCqNTa1ZqLWTJQA9YdNrfPPtvlD1aLdHW05jfrNRsex5I_DoKJx2Bm0LqDplfXu_we_JMV79w</recordid><startdate>19710101</startdate><enddate>19710101</enddate><creator>Fazekas, Arpad G.</creator><creator>Lanthier, André</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19710101</creationdate><title>Metabolism of androgens by isolated human beard hair follicles</title><author>Fazekas, Arpad G. ; Lanthier, André</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-f9d585df1d8345504acb9d23fe7e1b480c32d86da7d18dfb66621e50d295a4b13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Adult</topic><topic>Alcohols - biosynthesis</topic><topic>Androgens - metabolism</topic><topic>Androstanes - biosynthesis</topic><topic>Androstanes - metabolism</topic><topic>Androsterone - biosynthesis</topic><topic>Chromatography, Paper</topic><topic>Chromatography, Thin Layer</topic><topic>Dehydroepiandrosterone - metabolism</topic><topic>Female</topic><topic>Hair - anatomy & histology</topic><topic>Hair - metabolism</topic><topic>Hirsutism - metabolism</topic><topic>Humans</topic><topic>Ketosteroids - biosynthesis</topic><topic>Ketosteroids - metabolism</topic><topic>Male</topic><topic>Testosterone - biosynthesis</topic><topic>Testosterone - metabolism</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fazekas, Arpad G.</creatorcontrib><creatorcontrib>Lanthier, André</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Steroids</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fazekas, Arpad G.</au><au>Lanthier, André</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolism of androgens by isolated human beard hair follicles</atitle><jtitle>Steroids</jtitle><addtitle>Steroids</addtitle><date>1971-01-01</date><risdate>1971</risdate><volume>18</volume><issue>4</issue><spage>367</spage><epage>379</epage><pages>367-379</pages><issn>0039-128X</issn><eissn>1878-5867</eissn><abstract>Human beard hair follicles were incubated
in vitro
with testosterone-7-
3H, androstenedione-1,2-
3H and dehydroepiandrosterone-4-
14C.The principal metabolites of testosterone were androstenedione, 5α-androstanedione, 5α-dihydrotestosterone and androsterone. The conversion of androstenedione into testosterone and 5α-dihydrotestosterone was very limited. Dehydroepiandrosterone was metabolized to 5-androstene-3β,17β-diol, 7α-hydroxy-dehydroepiandrosterone and androstenedione, with rates of formation far exceeding those reported for human skin. The significance of these metabolic transformations is discussed with special reference to the mechanism of action of androgens.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>4257277</pmid><doi>10.1016/0039-128X(71)90051-1</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-128X |
| ispartof | Steroids, 1971-01, Vol.18 (4), p.367-379 |
| issn | 0039-128X 1878-5867 |
| language | eng |
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| source | Elsevier ScienceDirect Journals Complete - AutoHoldings; MEDLINE |
| subjects | Adult Alcohols - biosynthesis Androgens - metabolism Androstanes - biosynthesis Androstanes - metabolism Androsterone - biosynthesis Chromatography, Paper Chromatography, Thin Layer Dehydroepiandrosterone - metabolism Female Hair - anatomy & histology Hair - metabolism Hirsutism - metabolism Humans Ketosteroids - biosynthesis Ketosteroids - metabolism Male Testosterone - biosynthesis Testosterone - metabolism Tritium |
| title | Metabolism of androgens by isolated human beard hair follicles |
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