Luteinizing hormone-releasing hormone antagonists containing very hydrophobic amino acids

In a continuation of our studies on the effects of hydrophobic substitutions in analogues of luteinizing hormone-releasing hormone (LH-RH), we have synthesized LH-RH antagonists containing the very hydrophobic amino acid 3-(2-naphthyl)-D-alanine (D-Nal(2)). The D-Nal(2) substitution was found to be...

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Veröffentlicht in:	Journal of medicinal chemistry 1984-09, Vol.27 (9), p.1170-1174
Hauptverfasser:	Nestor, John J, Tahilramani, Ram, Ho, Teresa L, McRae, Georgia I, Vickery, Brian H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences Female Fundamental and applied biological sciences. Psychology Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - antagonists & inhibitors Hormones - chemical synthesis luteinizing hormone-releasing hormone Ovulation - drug effects peptide synthesis Proteins Rats Solubility Structure-Activity Relationship
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