Action Profile of the Antiobesity Drug Candidate Oleoyl‐Estrone in Rats

Oleoyl‐estrone (OE) has been presented as a potential antiobesity therapeutic, but the published series of studies from one laboratory has not yet been independently confirmed, and the exact mechanism of action is unknown. Based on the hypothesis that OE has potential for the treatment of obesity, m...

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Veröffentlicht in:	Obesity (Silver Spring, Md.) Md.), 2010-12, Vol.18 (12), p.2260-2267
Hauptverfasser:	Strassburg, Sabine, Pfluger, Paul T., Chaudhary, Nilika, Tso, Patrick, Tschöp, Matthias H., Anker, Stefan D., Nogueiras, Ruben, Perez‐Tilve, Diego
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose Tissue - drug effects Animals Anti-Obesity Agents - pharmacology Anti-Obesity Agents - therapeutic use Arcuate Nucleus of Hypothalamus - drug effects Arcuate Nucleus of Hypothalamus - metabolism Body Fluid Compartments - drug effects Energy Intake - drug effects Estrone - analogs & derivatives Estrone - pharmacology Estrone - therapeutic use Female Hypogonadism - chemically induced Hypothalamo-Hypophyseal System - drug effects In Situ Hybridization Liver - drug effects Liver - pathology Male Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Obesity - drug therapy Obesity - metabolism Obesity - pathology Oleic Acids - pharmacology Oleic Acids - therapeutic use Organ Size - drug effects Pituitary-Adrenal System - drug effects Rats Rats, Sprague-Dawley RNA, Messenger - metabolism Sex Factors Testosterone - blood Weight Gain - drug effects
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