Hydroxyindole-O-methyltransferase V: Effects of Substituents on Hydrolysis of N-Acyltryptamines in Rats

The effects of substituents on the hydrolysis of the amide linkage were studied in rats with five tritium-labeled, substituted N-benzoyltryptamines and N-phenylacetyltryptamines. In the blood, amides of phenylacetic acid were hydrolyzed at a faster rate than those of benzoic acid. Methylation of the...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1971-04, Vol.60 (4), p.634-635
Hauptverfasser:	Ho, Ben G.T., Fritchie, G. Edward, Noel, Michae L.B., McIsaac, William M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - enzymology Bromine Chromatography, Thin Layer effect on hydrolysis Hydrolysis Hydroxyindole-O-methyltransferase-substituted N-acyltryptamines Hydroxyindole-O-methyltransferase—substituted N-acyltryptamines, effect on hydrolysis, rats Male Methyltransferases - antagonists & inhibitors N-Acyltryptamines N-Acyltryptamines, substituted-effect on hydroxyindole-O-methyltransferase hydrolysis, rats Pineal Gland - enzymology Rats Rats, Inbred Strains substituted-effect on hydroxyindole-O-methyltransferase hydrolysis Time Factors TLC-separation Tritium Tryptamines - blood Tryptamines - chemical synthesis Tryptamines - pharmacology
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