The myriad roles of Anillin during cytokinesis
Anillin is a highly conserved multidomain protein that interacts with cytoskeletal components as well as their regulators. Throughout phylogeny, Anillins contribute to cytokinesis, the cell shape change that occurs at the end of meiosis and mitosis to separate a cell into daughter cells. Failed cyto...
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| Veröffentlicht in: | Seminars in cell & developmental biology 2010-12, Vol.21 (9), p.881-891 |
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| container_title | Seminars in cell & developmental biology |
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| creator | Piekny, Alisa J. Maddox, Amy Shaub |
| description | Anillin is a highly conserved multidomain protein that interacts with cytoskeletal components as well as their regulators. Throughout phylogeny, Anillins contribute to cytokinesis, the cell shape change that occurs at the end of meiosis and mitosis to separate a cell into daughter cells. Failed cytokinesis results in binucleation, which can lead to genomic instability. Study of Anillin in several model organisms has provided us with insight into how the cytoskeleton is coordinated to ensure that cytokinesis occurs with high fidelity. Here we review Anillin's interacting partners and the relevance of these interactions
in vivo. We also discuss questions of how these interactions are coordinated, and finally provide some perspective regarding Anillin's role in cancer. |
| doi_str_mv | 10.1016/j.semcdb.2010.08.002 |
| format | Article |
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| ispartof | Seminars in cell & developmental biology, 2010-12, Vol.21 (9), p.881-891 |
| issn | 1084-9521 1096-3634 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Cycle Cellularization Contractile Proteins - chemistry Contractile Proteins - metabolism Cytokinesis Cytoskeleton F-actin Humans Proteins - metabolism Rho |
| title | The myriad roles of Anillin during cytokinesis |
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