Endocytosis of HIV: anything goes
The major pathway for HIV internalization in CD4+ T cells has been thought to be the direct fusion of virus and cell membranes, because the cell surface is the point of entry of infectious particles. However, the exact contribution of endocytic pathways to the infection of CD4+ T lymphocytes is unkn...
Gespeichert in:
| Veröffentlicht in: | Trends in microbiology (Regular ed.) 2010-12, Vol.18 (12), p.543-551 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 551 |
|---|---|
| container_issue | 12 |
| container_start_page | 543 |
| container_title | Trends in microbiology (Regular ed.) |
| container_volume | 18 |
| creator | Permanyer, Marc Ballana, Ester Esté, José A |
| description | The major pathway for HIV internalization in CD4+ T cells has been thought to be the direct fusion of virus and cell membranes, because the cell surface is the point of entry of infectious particles. However, the exact contribution of endocytic pathways to the infection of CD4+ T lymphocytes is unknown, and the mechanisms involved in endocytosis of HIV particles are unclear. Recent evidence suggests that endocytosis of cell-free and cell-associated virus particles could lead to effective virus entry and productive infections. Such observations have, in turn, spurred a debate on the relevance of endosomal entry as a mechanism of escape from the immune system and HIV entry inhibitors. In this paper, we review the endocytosis of HIV and discuss its role in HIV infection and pathogenesis. |
| doi_str_mv | 10.1016/j.tim.2010.09.003 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_812137389</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0966842X1000171X</els_id><sourcerecordid>812137389</sourcerecordid><originalsourceid>FETCH-LOGICAL-c440t-4b7d1e09caa4c8c72b51634a982fcfd6ec6e3031103984053af06ef27952e18f3</originalsourceid><addsrcrecordid>eNp9kUtLAzEUhYMotj5-gBupK91MvTeZR6IgiPgCwYUPugtp5k5NnU50MhX6701pdeHCVbjkO2fxHcYOEIYImJ9Oh52bDTnEG9QQQGywPspCJqmQsMn6oPI8kSkf9dhOCFMAyDKebbMejz9ZwVWfHV03pbeLzgcXBr4a3N2_ng1Ms-jeXDMZTDyFPbZVmTrQ_vrdZS83189Xd8nD4-391eVDYtMUuiQdFyUSKGtMaqUt-DjDXKRGSV7ZqszJ5iRAIIJQMoVMmApyqnihMk4oK7HLjle9H63_nFPo9MwFS3VtGvLzoCVyFIWQKpIn_5IIHKTIM8UjiivUtj6Elir90bqZaRcR0kuHeqqjQ710qEHp6DBmDtf18_GMyt_Ej7QInK8Aijq-HLU6WEeNpdK1ZDtdevdv_cWftK1d46yp32lBYernbRM9a9SBa9BPyxGXG2KcDwsciW-2V5Pq</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1020836592</pqid></control><display><type>article</type><title>Endocytosis of HIV: anything goes</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Permanyer, Marc ; Ballana, Ester ; Esté, José A</creator><creatorcontrib>Permanyer, Marc ; Ballana, Ester ; Esté, José A</creatorcontrib><description>The major pathway for HIV internalization in CD4+ T cells has been thought to be the direct fusion of virus and cell membranes, because the cell surface is the point of entry of infectious particles. However, the exact contribution of endocytic pathways to the infection of CD4+ T lymphocytes is unknown, and the mechanisms involved in endocytosis of HIV particles are unclear. Recent evidence suggests that endocytosis of cell-free and cell-associated virus particles could lead to effective virus entry and productive infections. Such observations have, in turn, spurred a debate on the relevance of endosomal entry as a mechanism of escape from the immune system and HIV entry inhibitors. In this paper, we review the endocytosis of HIV and discuss its role in HIV infection and pathogenesis.</description><identifier>ISSN: 0966-842X</identifier><identifier>EISSN: 1878-4380</identifier><identifier>DOI: 10.1016/j.tim.2010.09.003</identifier><identifier>PMID: 20965729</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>CD4-Positive T-Lymphocytes - virology ; Endocytosis - drug effects ; HIV - pathogenicity ; HIV - physiology ; HIV Infections - virology ; Human immunodeficiency virus ; Humans ; Immune Evasion ; Internal Medicine ; Virus Internalization</subject><ispartof>Trends in microbiology (Regular ed.), 2010-12, Vol.18 (12), p.543-551</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>Copyright © 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c440t-4b7d1e09caa4c8c72b51634a982fcfd6ec6e3031103984053af06ef27952e18f3</citedby><cites>FETCH-LOGICAL-c440t-4b7d1e09caa4c8c72b51634a982fcfd6ec6e3031103984053af06ef27952e18f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.tim.2010.09.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20965729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Permanyer, Marc</creatorcontrib><creatorcontrib>Ballana, Ester</creatorcontrib><creatorcontrib>Esté, José A</creatorcontrib><title>Endocytosis of HIV: anything goes</title><title>Trends in microbiology (Regular ed.)</title><addtitle>Trends Microbiol</addtitle><description>The major pathway for HIV internalization in CD4+ T cells has been thought to be the direct fusion of virus and cell membranes, because the cell surface is the point of entry of infectious particles. However, the exact contribution of endocytic pathways to the infection of CD4+ T lymphocytes is unknown, and the mechanisms involved in endocytosis of HIV particles are unclear. Recent evidence suggests that endocytosis of cell-free and cell-associated virus particles could lead to effective virus entry and productive infections. Such observations have, in turn, spurred a debate on the relevance of endosomal entry as a mechanism of escape from the immune system and HIV entry inhibitors. In this paper, we review the endocytosis of HIV and discuss its role in HIV infection and pathogenesis.</description><subject>CD4-Positive T-Lymphocytes - virology</subject><subject>Endocytosis - drug effects</subject><subject>HIV - pathogenicity</subject><subject>HIV - physiology</subject><subject>HIV Infections - virology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Immune Evasion</subject><subject>Internal Medicine</subject><subject>Virus Internalization</subject><issn>0966-842X</issn><issn>1878-4380</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kUtLAzEUhYMotj5-gBupK91MvTeZR6IgiPgCwYUPugtp5k5NnU50MhX6701pdeHCVbjkO2fxHcYOEIYImJ9Oh52bDTnEG9QQQGywPspCJqmQsMn6oPI8kSkf9dhOCFMAyDKebbMejz9ZwVWfHV03pbeLzgcXBr4a3N2_ng1Ms-jeXDMZTDyFPbZVmTrQ_vrdZS83189Xd8nD4-391eVDYtMUuiQdFyUSKGtMaqUt-DjDXKRGSV7ZqszJ5iRAIIJQMoVMmApyqnihMk4oK7HLjle9H63_nFPo9MwFS3VtGvLzoCVyFIWQKpIn_5IIHKTIM8UjiivUtj6Elir90bqZaRcR0kuHeqqjQ710qEHp6DBmDtf18_GMyt_Ej7QInK8Aijq-HLU6WEeNpdK1ZDtdevdv_cWftK1d46yp32lBYernbRM9a9SBa9BPyxGXG2KcDwsciW-2V5Pq</recordid><startdate>20101201</startdate><enddate>20101201</enddate><creator>Permanyer, Marc</creator><creator>Ballana, Ester</creator><creator>Esté, José A</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20101201</creationdate><title>Endocytosis of HIV: anything goes</title><author>Permanyer, Marc ; Ballana, Ester ; Esté, José A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c440t-4b7d1e09caa4c8c72b51634a982fcfd6ec6e3031103984053af06ef27952e18f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>CD4-Positive T-Lymphocytes - virology</topic><topic>Endocytosis - drug effects</topic><topic>HIV - pathogenicity</topic><topic>HIV - physiology</topic><topic>HIV Infections - virology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Immune Evasion</topic><topic>Internal Medicine</topic><topic>Virus Internalization</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Permanyer, Marc</creatorcontrib><creatorcontrib>Ballana, Ester</creatorcontrib><creatorcontrib>Esté, José A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in microbiology (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Permanyer, Marc</au><au>Ballana, Ester</au><au>Esté, José A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocytosis of HIV: anything goes</atitle><jtitle>Trends in microbiology (Regular ed.)</jtitle><addtitle>Trends Microbiol</addtitle><date>2010-12-01</date><risdate>2010</risdate><volume>18</volume><issue>12</issue><spage>543</spage><epage>551</epage><pages>543-551</pages><issn>0966-842X</issn><eissn>1878-4380</eissn><abstract>The major pathway for HIV internalization in CD4+ T cells has been thought to be the direct fusion of virus and cell membranes, because the cell surface is the point of entry of infectious particles. However, the exact contribution of endocytic pathways to the infection of CD4+ T lymphocytes is unknown, and the mechanisms involved in endocytosis of HIV particles are unclear. Recent evidence suggests that endocytosis of cell-free and cell-associated virus particles could lead to effective virus entry and productive infections. Such observations have, in turn, spurred a debate on the relevance of endosomal entry as a mechanism of escape from the immune system and HIV entry inhibitors. In this paper, we review the endocytosis of HIV and discuss its role in HIV infection and pathogenesis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>20965729</pmid><doi>10.1016/j.tim.2010.09.003</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0966-842X |
| ispartof | Trends in microbiology (Regular ed.), 2010-12, Vol.18 (12), p.543-551 |
| issn | 0966-842X 1878-4380 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_812137389 |
| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | CD4-Positive T-Lymphocytes - virology Endocytosis - drug effects HIV - pathogenicity HIV - physiology HIV Infections - virology Human immunodeficiency virus Humans Immune Evasion Internal Medicine Virus Internalization |
| title | Endocytosis of HIV: anything goes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-02T18%3A18%3A26IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endocytosis%20of%20HIV:%20anything%20goes&rft.jtitle=Trends%20in%20microbiology%20(Regular%20ed.)&rft.au=Permanyer,%20Marc&rft.date=2010-12-01&rft.volume=18&rft.issue=12&rft.spage=543&rft.epage=551&rft.pages=543-551&rft.issn=0966-842X&rft.eissn=1878-4380&rft_id=info:doi/10.1016/j.tim.2010.09.003&rft_dat=%3Cproquest_cross%3E812137389%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1020836592&rft_id=info:pmid/20965729&rft_els_id=S0966842X1000171X&rfr_iscdi=true |