Biomarkers for the Diagnosis of the Stable Kidney Transplant and Chronic Transplant Injury Using the ProtoArray® Technology
Abstract Transplant glomerulopathy (TG), a form of chronic renal transplant rejection, carries a poor prognosis. It must be differentiated from the entity defined by the Banff '05 classification, interstitial fibrosis/tubular atrophy (IF/TA). Sequential transplant biopsies have shown that these...
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| Veröffentlicht in: | Transplantation proceedings 2010-11, Vol.42 (9), p.3475-3481 |
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| description | Abstract Transplant glomerulopathy (TG), a form of chronic renal transplant rejection, carries a poor prognosis. It must be differentiated from the entity defined by the Banff '05 classification, interstitial fibrosis/tubular atrophy (IF/TA). Sequential transplant biopsies have shown that these lesions are subclinical long before clinical manifestations. The availability of biomarkers may provide an earlier diagnosis and subsequent treatment. The aim of our study was to identify serum biomarkers in kidney recipients showing TG compared with IF/TA or stable patients, using protein microarray technology. This technology detects auto- or alloantibodies in patient sera. With a high degree of statistical significance, we identified 18 antibody reactivities specific for TG; 11 for IF/TA; and 10 among stable patients. Target proteins were involved in signal transduction, transcription regulation, DNA replication and repair, cell cycle, endocytosis, cell redox, as well as glycolysis. Some markers, such as podocan and collagen XXIII among TG and tubular cell ion channels among IF/TA, possibly provide insights into the pathogenesis of the lesions. |
| doi_str_mv | 10.1016/j.transproceed.2010.09.006 |
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It must be differentiated from the entity defined by the Banff '05 classification, interstitial fibrosis/tubular atrophy (IF/TA). Sequential transplant biopsies have shown that these lesions are subclinical long before clinical manifestations. The availability of biomarkers may provide an earlier diagnosis and subsequent treatment. The aim of our study was to identify serum biomarkers in kidney recipients showing TG compared with IF/TA or stable patients, using protein microarray technology. This technology detects auto- or alloantibodies in patient sera. With a high degree of statistical significance, we identified 18 antibody reactivities specific for TG; 11 for IF/TA; and 10 among stable patients. Target proteins were involved in signal transduction, transcription regulation, DNA replication and repair, cell cycle, endocytosis, cell redox, as well as glycolysis. Some markers, such as podocan and collagen XXIII among TG and tubular cell ion channels among IF/TA, possibly provide insights into the pathogenesis of the lesions.</description><identifier>ISSN: 0041-1345</identifier><identifier>EISSN: 1873-2623</identifier><identifier>DOI: 10.1016/j.transproceed.2010.09.006</identifier><identifier>PMID: 21094800</identifier><identifier>CODEN: TRPPA8</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Adult ; Aged ; Atrophy ; Autoantibodies - blood ; Biological and medical sciences ; Biomarkers - blood ; Biopsy ; Chronic Disease ; Female ; Fibrosis ; France ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Graft Rejection - diagnosis ; Graft Rejection - etiology ; Graft Rejection - immunology ; Graft Rejection - pathology ; Humans ; Injuries of the urinary system. Foreign bodies. Diseases due to physical agents ; Isoantibodies - blood ; Kidney - pathology ; Kidney Transplantation - adverse effects ; Male ; Medical sciences ; Middle Aged ; Predictive Value of Tests ; Protein Array Analysis ; Surgery ; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases ; Tissue, organ and graft immunology ; Traumas. Diseases due to physical agents ; Treatment Outcome ; Young Adult</subject><ispartof>Transplantation proceedings, 2010-11, Vol.42 (9), p.3475-3481</ispartof><rights>Elsevier Inc.</rights><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c530t-321b6a1d14c9d7d3e8e107dbfa1733a2909cdf37fbec2aac52199b7256b4b0953</citedby><cites>FETCH-LOGICAL-c530t-321b6a1d14c9d7d3e8e107dbfa1733a2909cdf37fbec2aac52199b7256b4b0953</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.transproceed.2010.09.006$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23597718$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21094800$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Le Roux, S</creatorcontrib><creatorcontrib>Devys, A</creatorcontrib><creatorcontrib>Girard, C</creatorcontrib><creatorcontrib>Harb, J</creatorcontrib><creatorcontrib>Hourmant, M</creatorcontrib><title>Biomarkers for the Diagnosis of the Stable Kidney Transplant and Chronic Transplant Injury Using the ProtoArray® Technology</title><title>Transplantation proceedings</title><addtitle>Transplant Proc</addtitle><description>Abstract Transplant glomerulopathy (TG), a form of chronic renal transplant rejection, carries a poor prognosis. It must be differentiated from the entity defined by the Banff '05 classification, interstitial fibrosis/tubular atrophy (IF/TA). Sequential transplant biopsies have shown that these lesions are subclinical long before clinical manifestations. The availability of biomarkers may provide an earlier diagnosis and subsequent treatment. The aim of our study was to identify serum biomarkers in kidney recipients showing TG compared with IF/TA or stable patients, using protein microarray technology. This technology detects auto- or alloantibodies in patient sera. With a high degree of statistical significance, we identified 18 antibody reactivities specific for TG; 11 for IF/TA; and 10 among stable patients. Target proteins were involved in signal transduction, transcription regulation, DNA replication and repair, cell cycle, endocytosis, cell redox, as well as glycolysis. Some markers, such as podocan and collagen XXIII among TG and tubular cell ion channels among IF/TA, possibly provide insights into the pathogenesis of the lesions.</description><subject>Adult</subject><subject>Aged</subject><subject>Atrophy</subject><subject>Autoantibodies - blood</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Biopsy</subject><subject>Chronic Disease</subject><subject>Female</subject><subject>Fibrosis</subject><subject>France</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Rejection - diagnosis</subject><subject>Graft Rejection - etiology</subject><subject>Graft Rejection - immunology</subject><subject>Graft Rejection - pathology</subject><subject>Humans</subject><subject>Injuries of the urinary system. Foreign bodies. Diseases due to physical agents</subject><subject>Isoantibodies - blood</subject><subject>Kidney - pathology</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Predictive Value of Tests</subject><subject>Protein Array Analysis</subject><subject>Surgery</subject><subject>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</subject><subject>Tissue, organ and graft immunology</subject><subject>Traumas. Diseases due to physical agents</subject><subject>Treatment Outcome</subject><subject>Young Adult</subject><issn>0041-1345</issn><issn>1873-2623</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNktuKFDEQhoMo7rj6ChIE8WrGStKneCGssx4WFxR29jqk09Uz6e1JdpNuocFn8iF8MjOHxcUrr0Kq_vqr-KoIecVgwYAVb7vFELSLt8EbxGbBISVALgCKR2TGqlLMecHFYzIDyNiciSw_Ic9i7CD9eSaekhPOQGYVwIz8_GD9VocbDJG2PtBhg_Tc6rXz0Ubq233gatB1j_SrbRxOdLVv3ms3UO0autwE76x5GL5w3Rgmeh2tW-8Nvgc_-LMQ9PT7F12h2Tjf-_X0nDxpdR_xxfE9JdefPq6WX-aX3z5fLM8u5yYXMMwFZ3WhWcMyI5uyEVghg7KpW81KITSXIE3TirKt0XCtTc6ZlHXJ86LOapC5OCVvDr4J2d2IcVBbGw32aVj0Y1QV40yUoiiT8t1BaYKPMWCrboNNfCbFQO3gq049hK928BVIleCn4pfHNmO9Tbn70nvaSfD6KNDR6L5NRsbGvzqRy7JkVdKdH3SYoPywGFQ0Fp3BxgY0g2q8_b953v9jY3qbVqX7G5wwdn4MLmFXTEWuQF3tzmV3LQyAiQRd_AH_68EP</recordid><startdate>20101101</startdate><enddate>20101101</enddate><creator>Le Roux, S</creator><creator>Devys, A</creator><creator>Girard, C</creator><creator>Harb, J</creator><creator>Hourmant, M</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20101101</creationdate><title>Biomarkers for the Diagnosis of the Stable Kidney Transplant and Chronic Transplant Injury Using the ProtoArray® Technology</title><author>Le Roux, S ; Devys, A ; Girard, C ; Harb, J ; Hourmant, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c530t-321b6a1d14c9d7d3e8e107dbfa1733a2909cdf37fbec2aac52199b7256b4b0953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Atrophy</topic><topic>Autoantibodies - blood</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Biopsy</topic><topic>Chronic Disease</topic><topic>Female</topic><topic>Fibrosis</topic><topic>France</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Rejection - diagnosis</topic><topic>Graft Rejection - etiology</topic><topic>Graft Rejection - immunology</topic><topic>Graft Rejection - pathology</topic><topic>Humans</topic><topic>Injuries of the urinary system. Foreign bodies. Diseases due to physical agents</topic><topic>Isoantibodies - blood</topic><topic>Kidney - pathology</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Predictive Value of Tests</topic><topic>Protein Array Analysis</topic><topic>Surgery</topic><topic>Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases</topic><topic>Tissue, organ and graft immunology</topic><topic>Traumas. Diseases due to physical agents</topic><topic>Treatment Outcome</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Le Roux, S</creatorcontrib><creatorcontrib>Devys, A</creatorcontrib><creatorcontrib>Girard, C</creatorcontrib><creatorcontrib>Harb, J</creatorcontrib><creatorcontrib>Hourmant, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Transplantation proceedings</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Le Roux, S</au><au>Devys, A</au><au>Girard, C</au><au>Harb, J</au><au>Hourmant, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biomarkers for the Diagnosis of the Stable Kidney Transplant and Chronic Transplant Injury Using the ProtoArray® Technology</atitle><jtitle>Transplantation proceedings</jtitle><addtitle>Transplant Proc</addtitle><date>2010-11-01</date><risdate>2010</risdate><volume>42</volume><issue>9</issue><spage>3475</spage><epage>3481</epage><pages>3475-3481</pages><issn>0041-1345</issn><eissn>1873-2623</eissn><coden>TRPPA8</coden><abstract>Abstract Transplant glomerulopathy (TG), a form of chronic renal transplant rejection, carries a poor prognosis. It must be differentiated from the entity defined by the Banff '05 classification, interstitial fibrosis/tubular atrophy (IF/TA). Sequential transplant biopsies have shown that these lesions are subclinical long before clinical manifestations. The availability of biomarkers may provide an earlier diagnosis and subsequent treatment. The aim of our study was to identify serum biomarkers in kidney recipients showing TG compared with IF/TA or stable patients, using protein microarray technology. This technology detects auto- or alloantibodies in patient sera. With a high degree of statistical significance, we identified 18 antibody reactivities specific for TG; 11 for IF/TA; and 10 among stable patients. Target proteins were involved in signal transduction, transcription regulation, DNA replication and repair, cell cycle, endocytosis, cell redox, as well as glycolysis. Some markers, such as podocan and collagen XXIII among TG and tubular cell ion channels among IF/TA, possibly provide insights into the pathogenesis of the lesions.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>21094800</pmid><doi>10.1016/j.transproceed.2010.09.006</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Atrophy Autoantibodies - blood Biological and medical sciences Biomarkers - blood Biopsy Chronic Disease Female Fibrosis France Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - diagnosis Graft Rejection - etiology Graft Rejection - immunology Graft Rejection - pathology Humans Injuries of the urinary system. Foreign bodies. Diseases due to physical agents Isoantibodies - blood Kidney - pathology Kidney Transplantation - adverse effects Male Medical sciences Middle Aged Predictive Value of Tests Protein Array Analysis Surgery Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Tissue, organ and graft immunology Traumas. Diseases due to physical agents Treatment Outcome Young Adult |
| title | Biomarkers for the Diagnosis of the Stable Kidney Transplant and Chronic Transplant Injury Using the ProtoArray® Technology |
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