Effect of Cognitive Remediation on Gait in Sedentary Seniors
Background. Attention and executive functions show strong associations with slow gait and falls in seniors and have been shown to be amenable to cognitive remediation. However, cognitive remediation as a strategy to improve mobility has not been investigated. Methods. Using a randomized single-blind...
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| Veröffentlicht in: | The journals of gerontology. Series A, Biological sciences and medical sciences Biological sciences and medical sciences, 2010-12, Vol.65A (12), p.1338-1343 |
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| container_title | The journals of gerontology. Series A, Biological sciences and medical sciences |
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| creator | Verghese, Joe Mahoney, Jeannette Ambrose, Anne F. Wang, Cuiling Holtzer, Roee |
| description | Background. Attention and executive functions show strong associations with slow gait and falls in seniors and have been shown to be amenable to cognitive remediation. However, cognitive remediation as a strategy to improve mobility has not been investigated. Methods. Using a randomized single-blind control design, 24 sedentary older adults (exercise less than or equal to once weekly and gait velocity |
| doi_str_mv | 10.1093/gerona/glq127 |
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Attention and executive functions show strong associations with slow gait and falls in seniors and have been shown to be amenable to cognitive remediation. However, cognitive remediation as a strategy to improve mobility has not been investigated. Methods. Using a randomized single-blind control design, 24 sedentary older adults (exercise less than or equal to once weekly and gait velocity <1 m/s) were randomly assigned to an 8-week computerized cognitive remediation program or wait-list. Primary outcome was change in gait velocity during normal pace and “walking while talking” conditions. We also compared the proportion of improvers (velocity change ≥4 cm/s) in each group. Results. The 10 participants who completed cognitive remediation improved gait velocity from baseline during normal walking (68.2 ± 20.0 vs 76.5 ± 17.9 cm/s, p = .05) and walking while talking (36.7 ± 13.5 vs 56.7 ± 20.4 cm/s, p = .002). The 10 intervention participants improved gait velocity over the 8-week intervention both during normal walking (change: 8.2 ± 11.4–1.3 ± 6.8 cm/s, p = .10) and walking while talking (change: 19.9 ± 14.9–2.5 ± 20.1 cm/s, p = .05) compared with the 10 control participants. Six intervention participants were improvers on normal pace walking compared with three controls (odds ratio = 3.0, 95% confidence interval = 0.5–19.6). All 10 intervention participants improved on walking while talking compared with 3 controls (odds ratio = 3.5, 95% confidence interval = 1.5–8.0). Conclusions. The findings of this pilot trial are promising and suggest that cognitive remediation may improve mobility in sedentary seniors. This approach should be validated in larger scale trials.</description><identifier>ISSN: 1079-5006</identifier><identifier>EISSN: 1758-535X</identifier><identifier>DOI: 10.1093/gerona/glq127</identifier><identifier>PMID: 20643703</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Attention ; Clinical trials ; Cognition & reasoning ; Cognition Disorders - physiopathology ; Cognition Disorders - rehabilitation ; Cognitive remediation ; Female ; Gait ; Gait velocity ; Humans ; Male ; Motor ability ; Older people ; Pilot Projects ; Sedentary Lifestyle ; Single-Blind Method ; Treatment Outcome ; Walking</subject><ispartof>The journals of gerontology. Series A, Biological sciences and medical sciences, 2010-12, Vol.65A (12), p.1338-1343</ispartof><rights>The Author 2010. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org. 2010</rights><rights>Copyright Oxford University Press, UK Dec 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-3e52b597d83e7b7aa6ba5f40a64d688ffbf784bdf47243d1f8be2dca527905fb3</citedby><cites>FETCH-LOGICAL-c429t-3e52b597d83e7b7aa6ba5f40a64d688ffbf784bdf47243d1f8be2dca527905fb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1584,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20643703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Verghese, Joe</creatorcontrib><creatorcontrib>Mahoney, Jeannette</creatorcontrib><creatorcontrib>Ambrose, Anne F.</creatorcontrib><creatorcontrib>Wang, Cuiling</creatorcontrib><creatorcontrib>Holtzer, Roee</creatorcontrib><title>Effect of Cognitive Remediation on Gait in Sedentary Seniors</title><title>The journals of gerontology. Series A, Biological sciences and medical sciences</title><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><description>Background. Attention and executive functions show strong associations with slow gait and falls in seniors and have been shown to be amenable to cognitive remediation. However, cognitive remediation as a strategy to improve mobility has not been investigated. Methods. Using a randomized single-blind control design, 24 sedentary older adults (exercise less than or equal to once weekly and gait velocity <1 m/s) were randomly assigned to an 8-week computerized cognitive remediation program or wait-list. Primary outcome was change in gait velocity during normal pace and “walking while talking” conditions. We also compared the proportion of improvers (velocity change ≥4 cm/s) in each group. Results. The 10 participants who completed cognitive remediation improved gait velocity from baseline during normal walking (68.2 ± 20.0 vs 76.5 ± 17.9 cm/s, p = .05) and walking while talking (36.7 ± 13.5 vs 56.7 ± 20.4 cm/s, p = .002). The 10 intervention participants improved gait velocity over the 8-week intervention both during normal walking (change: 8.2 ± 11.4–1.3 ± 6.8 cm/s, p = .10) and walking while talking (change: 19.9 ± 14.9–2.5 ± 20.1 cm/s, p = .05) compared with the 10 control participants. Six intervention participants were improvers on normal pace walking compared with three controls (odds ratio = 3.0, 95% confidence interval = 0.5–19.6). All 10 intervention participants improved on walking while talking compared with 3 controls (odds ratio = 3.5, 95% confidence interval = 1.5–8.0). Conclusions. The findings of this pilot trial are promising and suggest that cognitive remediation may improve mobility in sedentary seniors. This approach should be validated in larger scale trials.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Attention</subject><subject>Clinical trials</subject><subject>Cognition & reasoning</subject><subject>Cognition Disorders - physiopathology</subject><subject>Cognition Disorders - rehabilitation</subject><subject>Cognitive remediation</subject><subject>Female</subject><subject>Gait</subject><subject>Gait velocity</subject><subject>Humans</subject><subject>Male</subject><subject>Motor ability</subject><subject>Older people</subject><subject>Pilot Projects</subject><subject>Sedentary Lifestyle</subject><subject>Single-Blind Method</subject><subject>Treatment Outcome</subject><subject>Walking</subject><issn>1079-5006</issn><issn>1758-535X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMoWqtHr7J40ctqvrMLXqRoq4iCXy1eQnY3Kantpia7ov_elK0evBgGMoeHd2YeAA4QPEUwJ2dT7V2tzqbzd4TFBughwbKUETbZjD0Uecog5DtgN4QZXD2Gt8EOhpwSAUkPnF8ao8smcSYZuGltG_uhkwe90JVVjXV1EmuobJPYOnnUla4b5b9iV1vnwx7YMmoe9P7674Pnq8unwSi9vR9eDy5u05LivEmJZrhguagyokUhlOKFYoZCxWnFs8yYwoiMFpWhAlNSIZMVGlelYljkkJmC9MFxl7v07r3VoZELG0o9n6tauzbIDGEUz0E8kkd_yJlrfR2XixDNIOWERCjtoNK7ELw2cuntIt4lEZQrqbKTKjupkT9ch7ZFFPNL_1iMwEkHuHb5b9Z6tg2N_vyFlX-TXBDB5GjyKm9GdHw3Hr5ITr4BAfCQxg</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Verghese, Joe</creator><creator>Mahoney, Jeannette</creator><creator>Ambrose, Anne F.</creator><creator>Wang, Cuiling</creator><creator>Holtzer, Roee</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>201012</creationdate><title>Effect of Cognitive Remediation on Gait in Sedentary Seniors</title><author>Verghese, Joe ; Mahoney, Jeannette ; Ambrose, Anne F. ; Wang, Cuiling ; Holtzer, Roee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-3e52b597d83e7b7aa6ba5f40a64d688ffbf784bdf47243d1f8be2dca527905fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Attention</topic><topic>Clinical trials</topic><topic>Cognition & reasoning</topic><topic>Cognition Disorders - physiopathology</topic><topic>Cognition Disorders - rehabilitation</topic><topic>Cognitive remediation</topic><topic>Female</topic><topic>Gait</topic><topic>Gait velocity</topic><topic>Humans</topic><topic>Male</topic><topic>Motor ability</topic><topic>Older people</topic><topic>Pilot Projects</topic><topic>Sedentary Lifestyle</topic><topic>Single-Blind Method</topic><topic>Treatment Outcome</topic><topic>Walking</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Verghese, Joe</creatorcontrib><creatorcontrib>Mahoney, Jeannette</creatorcontrib><creatorcontrib>Ambrose, Anne F.</creatorcontrib><creatorcontrib>Wang, Cuiling</creatorcontrib><creatorcontrib>Holtzer, Roee</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Verghese, Joe</au><au>Mahoney, Jeannette</au><au>Ambrose, Anne F.</au><au>Wang, Cuiling</au><au>Holtzer, Roee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Cognitive Remediation on Gait in Sedentary Seniors</atitle><jtitle>The journals of gerontology. Series A, Biological sciences and medical sciences</jtitle><addtitle>J Gerontol A Biol Sci Med Sci</addtitle><date>2010-12</date><risdate>2010</risdate><volume>65A</volume><issue>12</issue><spage>1338</spage><epage>1343</epage><pages>1338-1343</pages><issn>1079-5006</issn><eissn>1758-535X</eissn><abstract>Background. Attention and executive functions show strong associations with slow gait and falls in seniors and have been shown to be amenable to cognitive remediation. However, cognitive remediation as a strategy to improve mobility has not been investigated. Methods. Using a randomized single-blind control design, 24 sedentary older adults (exercise less than or equal to once weekly and gait velocity <1 m/s) were randomly assigned to an 8-week computerized cognitive remediation program or wait-list. Primary outcome was change in gait velocity during normal pace and “walking while talking” conditions. We also compared the proportion of improvers (velocity change ≥4 cm/s) in each group. Results. The 10 participants who completed cognitive remediation improved gait velocity from baseline during normal walking (68.2 ± 20.0 vs 76.5 ± 17.9 cm/s, p = .05) and walking while talking (36.7 ± 13.5 vs 56.7 ± 20.4 cm/s, p = .002). The 10 intervention participants improved gait velocity over the 8-week intervention both during normal walking (change: 8.2 ± 11.4–1.3 ± 6.8 cm/s, p = .10) and walking while talking (change: 19.9 ± 14.9–2.5 ± 20.1 cm/s, p = .05) compared with the 10 control participants. Six intervention participants were improvers on normal pace walking compared with three controls (odds ratio = 3.0, 95% confidence interval = 0.5–19.6). All 10 intervention participants improved on walking while talking compared with 3 controls (odds ratio = 3.5, 95% confidence interval = 1.5–8.0). Conclusions. The findings of this pilot trial are promising and suggest that cognitive remediation may improve mobility in sedentary seniors. This approach should be validated in larger scale trials.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>20643703</pmid><doi>10.1093/gerona/glq127</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Age Factors Aged Aged, 80 and over Attention Clinical trials Cognition & reasoning Cognition Disorders - physiopathology Cognition Disorders - rehabilitation Cognitive remediation Female Gait Gait velocity Humans Male Motor ability Older people Pilot Projects Sedentary Lifestyle Single-Blind Method Treatment Outcome Walking |
| title | Effect of Cognitive Remediation on Gait in Sedentary Seniors |
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