Decreased serum arylesterase activity in autism spectrum disorders

Abstract The PON1 gene, previously found associated with autism spectrum disorders (ASDs), encodes a serum protein responsible for the detoxification of organophosphates (OPs) and able to exert several enzymatic activities. PON1 arylesterase, but not diazoxonase activity, was significantly decreased...

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Veröffentlicht in:	Psychiatry research 2010-12, Vol.180 (2), p.105-113
Hauptverfasser:	Gaita, Laura, Manzi, Barbara, Sacco, Roberto, Lintas, Carla, Altieri, Laura, Lombardi, Federica, Pawlowski, Tracy L, Redman, Margot, Craig, David W, Huentelman, Matthew J, Ober-Reynolds, Sharman, Brautigam, Sarah, Melmed, Raun, Smith, Christopher J, Marsillach, Judith, Camps, Jordi, Curatolo, Paolo, Persico, Antonio M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aryldialkylphosphatase - genetics Aryldialkylphosphatase - metabolism Autistic disorder Biological and medical sciences Carboxylic Ester Hydrolases - blood Child Child clinical studies Child Development Disorders, Pervasive - blood Child Development Disorders, Pervasive - ethnology Child Development Disorders, Pervasive - genetics Child, Preschool Developmental disorders Diazoxonase Enzyme-Linked Immunosorbent Assay - methods European Continental Ancestry Group - genetics Family Female Gene Expression Regulation, Enzymologic - genetics Genetic Testing Genotype Humans Immune Infantile autism Italy - ethnology Male Medical sciences Middle Aged Organophosphate Paraoxonase Pervasive developmental disorders Polymorphism, Single Nucleotide - genetics Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Statistics, Nonparametric Young Adult
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