Divergent roles of reactive oxygen species in the responses of perinatal adrenal chromaffin cells to hypoxic challenges

Abstract The fetus and neonate experience variable patterns of low P O 2 (hypoxia) ranging from acute, sustained, and intermittent. Adaptation to hypoxia involves activation of key transcription factors, known as hypoxia-inducible factors (e.g. HIF-1α, HIF-2α), which regulate a number of genes in di...

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