Expression of Cyr61 (CCN1) in human oral squamous cell carcinoma: An independent marker for poor prognosis
Background. Cysteine‐rich 61 (Cyr61 [CCN1]) has disparate functions in tumorigenesis that are dependent on the cell types. The aim of the study was to investigate its role in the growth of oral squamous cell carcinoma (SCC). Methods. The study used immunohistochemistry to examine Cyr61 expression in...
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| Veröffentlicht in: | Head & neck 2010-12, Vol.32 (12), p.1665-1673 |
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| creator | Kok, Sang-Heng Chang, Hao-Hueng Tsai, Ju-Yi Hung, Hsin-Chia Lin, Chiao-Ying Chiang, Chun-Pin Liu, Cheing-Meei Kuo, Mark Yen-Ping |
| description | Background.
Cysteine‐rich 61 (Cyr61 [CCN1]) has disparate functions in tumorigenesis that are dependent on the cell types. The aim of the study was to investigate its role in the growth of oral squamous cell carcinoma (SCC).
Methods.
The study used immunohistochemistry to examine Cyr61 expression in 93 oral SCC specimens and assessed the effect of Cyr61 overexpression on proliferation and migration of oral SCC cells in vitro and xenograft growth in severe combined immunodeficient (SCID) mice.
Results.
High expression of Cyr61 significantly correlated with large tumor size (p = .009) and advanced tumor stage (p = .036). Multivariate analysis revealed that high Cyr61 (relative risk [RR] 2.44, 95% confidence interval [CI] 1.209–4.95, p = .010) significantly correlated with mortality. Forced expression of Cyr61 stimulated the motility and growth of Ca9‐22 cells in vitro and enhanced xenograft growth in SCID mice.
Conclusions.
Cyr61 is a positive growth modulator of oral SCC and Cyr61 overexpression is an independent prognostic indicator for patients with oral SCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010 |
| doi_str_mv | 10.1002/hed.21381 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_812135663</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>812135663</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4581-2ad87b80e4912c0f5c9b024a3de508f4cf4118b4daad9bf32c188b92ac038e823</originalsourceid><addsrcrecordid>eNp1kUtz0zAUhTUMDCmFRf9ARxsGunBz9bAtdxdMaGE6hQWPDhuNLEutWttKpHhI_j0KSWDF5kpz9d17zhwhdELgnADQ6b1pzylhgjxBRwSqMgPGy6fbO2cZg5JP0IsYHwCAFZw-RxMKggsOxRF6mK8XwcTo_IC9xfUmFAS_resbcobdgO_HXqWHoDocl6Pq_RixNl2HtQraDb5XF3g2JLI1C5PKsMK9Co8mYOsDXvhtCf5u8NHFl-iZVV00r_bnMfr2Yf61vsquP19-rGfXmea5IBlVrSgbAYZXhGqwua4aoFyx1uQgLNeWEyIa3irVVo1lVBMhmooqDUwYQdkxerPbm5SXo4kr2bu4Na0Gk_xLQVJWeVGwRJ7tSB18jMFYuQgu-d9IAnKbrEzJyj_JJvZ0v3Vs-tQ9kIcoE_B6D6ioVWeDGrSL_7j0Jbws8sRNd9wv15nN_xXl1fz9QTrbTbi4Muu_EylnWZSszOWPm0v57uf3Ej7dfpEF-w20o526</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>812135663</pqid></control><display><type>article</type><title>Expression of Cyr61 (CCN1) in human oral squamous cell carcinoma: An independent marker for poor prognosis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Kok, Sang-Heng ; Chang, Hao-Hueng ; Tsai, Ju-Yi ; Hung, Hsin-Chia ; Lin, Chiao-Ying ; Chiang, Chun-Pin ; Liu, Cheing-Meei ; Kuo, Mark Yen-Ping</creator><creatorcontrib>Kok, Sang-Heng ; Chang, Hao-Hueng ; Tsai, Ju-Yi ; Hung, Hsin-Chia ; Lin, Chiao-Ying ; Chiang, Chun-Pin ; Liu, Cheing-Meei ; Kuo, Mark Yen-Ping</creatorcontrib><description>Background.
Cysteine‐rich 61 (Cyr61 [CCN1]) has disparate functions in tumorigenesis that are dependent on the cell types. The aim of the study was to investigate its role in the growth of oral squamous cell carcinoma (SCC).
Methods.
The study used immunohistochemistry to examine Cyr61 expression in 93 oral SCC specimens and assessed the effect of Cyr61 overexpression on proliferation and migration of oral SCC cells in vitro and xenograft growth in severe combined immunodeficient (SCID) mice.
Results.
High expression of Cyr61 significantly correlated with large tumor size (p = .009) and advanced tumor stage (p = .036). Multivariate analysis revealed that high Cyr61 (relative risk [RR] 2.44, 95% confidence interval [CI] 1.209–4.95, p = .010) significantly correlated with mortality. Forced expression of Cyr61 stimulated the motility and growth of Ca9‐22 cells in vitro and enhanced xenograft growth in SCID mice.
Conclusions.
Cyr61 is a positive growth modulator of oral SCC and Cyr61 overexpression is an independent prognostic indicator for patients with oral SCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.21381</identifier><identifier>PMID: 20848406</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Animals ; Biological and medical sciences ; Biomarkers, Tumor - analysis ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; CCN proteins ; Cell Line, Tumor - metabolism ; Cell Line, Tumor - pathology ; Cell Movement ; Cell Proliferation - drug effects ; Cyr61 ; Cysteine-Rich Protein 61 - metabolism ; Cysteine-Rich Protein 61 - pharmacology ; Female ; Humans ; Immunohistochemistry ; Male ; Medical sciences ; Mice ; Mice, SCID ; Middle Aged ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Neoplasm Transplantation - pathology ; oral squamous cell carcinoma ; Otorhinolaryngology. Stomatology ; Prognosis ; Tumor Cells, Cultured ; tumor growth ; Tumors ; Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><ispartof>Head & neck, 2010-12, Vol.32 (12), p.1665-1673</ispartof><rights>Copyright © 2010 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4581-2ad87b80e4912c0f5c9b024a3de508f4cf4118b4daad9bf32c188b92ac038e823</citedby><cites>FETCH-LOGICAL-c4581-2ad87b80e4912c0f5c9b024a3de508f4cf4118b4daad9bf32c188b92ac038e823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.21381$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.21381$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23474765$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20848406$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kok, Sang-Heng</creatorcontrib><creatorcontrib>Chang, Hao-Hueng</creatorcontrib><creatorcontrib>Tsai, Ju-Yi</creatorcontrib><creatorcontrib>Hung, Hsin-Chia</creatorcontrib><creatorcontrib>Lin, Chiao-Ying</creatorcontrib><creatorcontrib>Chiang, Chun-Pin</creatorcontrib><creatorcontrib>Liu, Cheing-Meei</creatorcontrib><creatorcontrib>Kuo, Mark Yen-Ping</creatorcontrib><title>Expression of Cyr61 (CCN1) in human oral squamous cell carcinoma: An independent marker for poor prognosis</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
Cysteine‐rich 61 (Cyr61 [CCN1]) has disparate functions in tumorigenesis that are dependent on the cell types. The aim of the study was to investigate its role in the growth of oral squamous cell carcinoma (SCC).
Methods.
The study used immunohistochemistry to examine Cyr61 expression in 93 oral SCC specimens and assessed the effect of Cyr61 overexpression on proliferation and migration of oral SCC cells in vitro and xenograft growth in severe combined immunodeficient (SCID) mice.
Results.
High expression of Cyr61 significantly correlated with large tumor size (p = .009) and advanced tumor stage (p = .036). Multivariate analysis revealed that high Cyr61 (relative risk [RR] 2.44, 95% confidence interval [CI] 1.209–4.95, p = .010) significantly correlated with mortality. Forced expression of Cyr61 stimulated the motility and growth of Ca9‐22 cells in vitro and enhanced xenograft growth in SCID mice.
Conclusions.
Cyr61 is a positive growth modulator of oral SCC and Cyr61 overexpression is an independent prognostic indicator for patients with oral SCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>CCN proteins</subject><subject>Cell Line, Tumor - metabolism</subject><subject>Cell Line, Tumor - pathology</subject><subject>Cell Movement</subject><subject>Cell Proliferation - drug effects</subject><subject>Cyr61</subject><subject>Cysteine-Rich Protein 61 - metabolism</subject><subject>Cysteine-Rich Protein 61 - pharmacology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, SCID</subject><subject>Middle Aged</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Neoplasm Transplantation - pathology</subject><subject>oral squamous cell carcinoma</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>Tumor Cells, Cultured</subject><subject>tumor growth</subject><subject>Tumors</subject><subject>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUtz0zAUhTUMDCmFRf9ARxsGunBz9bAtdxdMaGE6hQWPDhuNLEutWttKpHhI_j0KSWDF5kpz9d17zhwhdELgnADQ6b1pzylhgjxBRwSqMgPGy6fbO2cZg5JP0IsYHwCAFZw-RxMKggsOxRF6mK8XwcTo_IC9xfUmFAS_resbcobdgO_HXqWHoDocl6Pq_RixNl2HtQraDb5XF3g2JLI1C5PKsMK9Co8mYOsDXvhtCf5u8NHFl-iZVV00r_bnMfr2Yf61vsquP19-rGfXmea5IBlVrSgbAYZXhGqwua4aoFyx1uQgLNeWEyIa3irVVo1lVBMhmooqDUwYQdkxerPbm5SXo4kr2bu4Na0Gk_xLQVJWeVGwRJ7tSB18jMFYuQgu-d9IAnKbrEzJyj_JJvZ0v3Vs-tQ9kIcoE_B6D6ioVWeDGrSL_7j0Jbws8sRNd9wv15nN_xXl1fz9QTrbTbi4Muu_EylnWZSszOWPm0v57uf3Ej7dfpEF-w20o526</recordid><startdate>201012</startdate><enddate>201012</enddate><creator>Kok, Sang-Heng</creator><creator>Chang, Hao-Hueng</creator><creator>Tsai, Ju-Yi</creator><creator>Hung, Hsin-Chia</creator><creator>Lin, Chiao-Ying</creator><creator>Chiang, Chun-Pin</creator><creator>Liu, Cheing-Meei</creator><creator>Kuo, Mark Yen-Ping</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201012</creationdate><title>Expression of Cyr61 (CCN1) in human oral squamous cell carcinoma: An independent marker for poor prognosis</title><author>Kok, Sang-Heng ; Chang, Hao-Hueng ; Tsai, Ju-Yi ; Hung, Hsin-Chia ; Lin, Chiao-Ying ; Chiang, Chun-Pin ; Liu, Cheing-Meei ; Kuo, Mark Yen-Ping</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4581-2ad87b80e4912c0f5c9b024a3de508f4cf4118b4daad9bf32c188b92ac038e823</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>CCN proteins</topic><topic>Cell Line, Tumor - metabolism</topic><topic>Cell Line, Tumor - pathology</topic><topic>Cell Movement</topic><topic>Cell Proliferation - drug effects</topic><topic>Cyr61</topic><topic>Cysteine-Rich Protein 61 - metabolism</topic><topic>Cysteine-Rich Protein 61 - pharmacology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, SCID</topic><topic>Middle Aged</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - pathology</topic><topic>Neoplasm Transplantation - pathology</topic><topic>oral squamous cell carcinoma</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>Tumor Cells, Cultured</topic><topic>tumor growth</topic><topic>Tumors</topic><topic>Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kok, Sang-Heng</creatorcontrib><creatorcontrib>Chang, Hao-Hueng</creatorcontrib><creatorcontrib>Tsai, Ju-Yi</creatorcontrib><creatorcontrib>Hung, Hsin-Chia</creatorcontrib><creatorcontrib>Lin, Chiao-Ying</creatorcontrib><creatorcontrib>Chiang, Chun-Pin</creatorcontrib><creatorcontrib>Liu, Cheing-Meei</creatorcontrib><creatorcontrib>Kuo, Mark Yen-Ping</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kok, Sang-Heng</au><au>Chang, Hao-Hueng</au><au>Tsai, Ju-Yi</au><au>Hung, Hsin-Chia</au><au>Lin, Chiao-Ying</au><au>Chiang, Chun-Pin</au><au>Liu, Cheing-Meei</au><au>Kuo, Mark Yen-Ping</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of Cyr61 (CCN1) in human oral squamous cell carcinoma: An independent marker for poor prognosis</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2010-12</date><risdate>2010</risdate><volume>32</volume><issue>12</issue><spage>1665</spage><epage>1673</epage><pages>1665-1673</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
Cysteine‐rich 61 (Cyr61 [CCN1]) has disparate functions in tumorigenesis that are dependent on the cell types. The aim of the study was to investigate its role in the growth of oral squamous cell carcinoma (SCC).
Methods.
The study used immunohistochemistry to examine Cyr61 expression in 93 oral SCC specimens and assessed the effect of Cyr61 overexpression on proliferation and migration of oral SCC cells in vitro and xenograft growth in severe combined immunodeficient (SCID) mice.
Results.
High expression of Cyr61 significantly correlated with large tumor size (p = .009) and advanced tumor stage (p = .036). Multivariate analysis revealed that high Cyr61 (relative risk [RR] 2.44, 95% confidence interval [CI] 1.209–4.95, p = .010) significantly correlated with mortality. Forced expression of Cyr61 stimulated the motility and growth of Ca9‐22 cells in vitro and enhanced xenograft growth in SCID mice.
Conclusions.
Cyr61 is a positive growth modulator of oral SCC and Cyr61 overexpression is an independent prognostic indicator for patients with oral SCC. © 2010 Wiley Periodicals, Inc. Head Neck, 2010</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>20848406</pmid><doi>10.1002/hed.21381</doi><tpages>9</tpages></addata></record> |
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| subjects | Animals Biological and medical sciences Biomarkers, Tumor - analysis Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology CCN proteins Cell Line, Tumor - metabolism Cell Line, Tumor - pathology Cell Movement Cell Proliferation - drug effects Cyr61 Cysteine-Rich Protein 61 - metabolism Cysteine-Rich Protein 61 - pharmacology Female Humans Immunohistochemistry Male Medical sciences Mice Mice, SCID Middle Aged Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Neoplasm Transplantation - pathology oral squamous cell carcinoma Otorhinolaryngology. Stomatology Prognosis Tumor Cells, Cultured tumor growth Tumors Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology |
| title | Expression of Cyr61 (CCN1) in human oral squamous cell carcinoma: An independent marker for poor prognosis |
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