A fast and simple assay for busulfan in serum or plasma by liquid chromatography–tandem mass spectrometry using turbulent flow online extraction technology

Busulfan is used in myeloablative preparation regimens for hematopoietic bone marrow transplantation. Due to its narrow therapeutic range therapeutic drug monitoring of busulfan is recommended. In this study a fast and simple method for measuring busulfan in serum or plasma by liquid chromatography–...

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Veröffentlicht in:	Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2010-12, Vol.878 (31), p.3255-3258
Hauptverfasser:	Bunch, Dustin R., Heideloff, Courtney, Ritchie, James C., Wang, Sihe
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetonitriles - chemistry Analysis Analytical, structural and metabolic biochemistry Biological and medical sciences Busulfan Busulfan - blood Chemical Fractionation - methods Chromatography Chromatography, Liquid - methods Drug Monitoring Fluid dynamics Fluid flow Fundamental and applied biological sciences. Psychology General pharmacology Humans Least-Squares Analysis Liquid chromatography Medical sciences On-line systems Online Pharmacology. Drug treatments Reproducibility of Results Serums Spectrometry, Mass, Electrospray Ionization Tandem mass spectrometry Tandem Mass Spectrometry - methods Turbulence Turbulent flow
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