Modulation of in vivo immunoglobulin production by endogenous histamine and H1R and H2R agonists and antagonists

The present study was designed to delineate the immunomodulatory role of histamine receptors (H1R and H2R) and their antibody generation in a rabbit model. Six groups containing 18 rabbits each received either vehicle (sterile distilled water, 1ml/kg×b.i.d), histamine (100µg/kg×b.i.d.), H1R agonist...

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Veröffentlicht in:	Pharmacological reports 2010-09, Vol.62 (5), p.917-925
Hauptverfasser:	Tripathi, Trivendra, Shahid, Mohammad, Khan, Haris M., Pal Singh Negi, Mahendra, Siddiqui, Mashiatullah, Khan, Rahat A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody Formation - drug effects Drug Safety and Pharmacovigilance Enzyme-Linked Immunosorbent Assay Female H1 agonists H1 antagonists H2 agonists H2 antagonists Hemagglutination Tests Histamine - administration & dosage Histamine - analogs & derivatives Histamine - pharmacology Histamine - physiology Histamine Agonists - administration & dosage Histamine Agonists - pharmacology Histamine H1 Antagonists - administration & dosage Histamine H1 Antagonists - pharmacology Histamine H2 Antagonists - administration & dosage Histamine H2 Antagonists - pharmacology histamine receptors humoral immune response Immunoglobulin G - biosynthesis Immunoglobulin G - blood Immunoglobulin M - biosynthesis Immunoglobulin M - blood Immunoglobulins - biosynthesis Immunoglobulins - blood Immunomodulation Male Pharmacotherapy Pharmacy Pheniramine - administration & dosage Pheniramine - pharmacology Rabbits Ranitidine - administration & dosage Ranitidine - pharmacology T-cell dependent antibody response Thiazoles - administration & dosage Thiazoles - pharmacology
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