Lysosomal exoglycosidases in serum and urine of patients with pancreatic adenocarcinoma
Lysosomal exoglycosidases: N-acetyl-β-D-hexosaminidase (HEX), β-D-galactosidase (GAL), α-L-fucosidase (FUC) and α-D-mannosidase (MAN) modify oligosaccharide chains of glycoconjugates in endoplasmatic reticulum and/or Golgi apparatus and degrade them in lysosomes. In acid environment of lysosome, exo...
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| description | Lysosomal exoglycosidases: N-acetyl-β-D-hexosaminidase (HEX), β-D-galactosidase (GAL), α-L-fucosidase (FUC) and α-D-mannosidase (MAN) modify oligosaccharide chains of glycoconjugates in endoplasmatic reticulum and/or Golgi apparatus and degrade them in lysosomes. In acid environment of lysosome, exoglycosidases degrade oligosaccharide chains of glycoproteins, glycolipids and glycosaminoglycans by eliminating single sugars from the edges of oligosaccharide chains. Neoplasms change biochemical processes in tissues and may significantly change the activity of many enzymes including the activity of lysosomal exoglycosidasses in serum and urine of persons with neoplasmatic diseases. The aim of the present paper was evaluation the activity of HEX, GAL, FUC and MAN in serum and urine of patients with pancreatic adenocarcinoma. Serum and urine samples were collected from 15 patients with adenocarcinoma of the pancreas and 15 healthy persons. The activity of lysosomal exoglycosidases was determined by the method of Marciniak et al. adapted to serum and urine of patients with adenocarcinoma of the pancreas. Our results indicate significant decrease in activity of GAL (p=0.037) in serum of patients with pancreatic adenocarcinoma, significant increase in activity of HEX (p |
| doi_str_mv | 10.2478/v10042-010-0060-9 |
| format | Article |
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In acid environment of lysosome, exoglycosidases degrade oligosaccharide chains of glycoproteins, glycolipids and glycosaminoglycans by eliminating single sugars from the edges of oligosaccharide chains. Neoplasms change biochemical processes in tissues and may significantly change the activity of many enzymes including the activity of lysosomal exoglycosidasses in serum and urine of persons with neoplasmatic diseases. The aim of the present paper was evaluation the activity of HEX, GAL, FUC and MAN in serum and urine of patients with pancreatic adenocarcinoma. Serum and urine samples were collected from 15 patients with adenocarcinoma of the pancreas and 15 healthy persons. The activity of lysosomal exoglycosidases was determined by the method of Marciniak et al. adapted to serum and urine of patients with adenocarcinoma of the pancreas. Our results indicate significant decrease in activity of GAL (p=0.037) in serum of patients with pancreatic adenocarcinoma, significant increase in activity of HEX (p<0.001) and FUC (p=0.027) in serum, and HEX (p=0.003) in urine, as well as significant decrease of FUC (p=0.016) and MAN (p=0.029) in urine o patients with adenocarcinoma of the pancreas, in comparison to the control group. Increase in activity of some lysosomal enzymes in serum and urine of pancreatic adenocarcinoma patients, may indicate on destruction of pancreatic tissue by pancreatic adenocarcinoma. Determination of the HEX, GAL, FUC and MAN in serum and urine may be useful in diagnostics of pancreatic adenocarcinoma.</description><identifier>ISSN: 0239-8508</identifier><identifier>EISSN: 1897-5631</identifier><identifier>DOI: 10.2478/v10042-010-0060-9</identifier><identifier>PMID: 21071338</identifier><language>eng</language><publisher>Poland: Wydawnictwo Via Medica</publisher><subject>Adenocarcinoma ; Adenocarcinoma - blood ; Adenocarcinoma - enzymology ; Adenocarcinoma - urine ; Adult ; Aged ; alpha-L-Fucosidase - metabolism ; alpha-L-Fucosidase - urine ; alpha-Mannosidase - metabolism ; beta-Galactosidase - metabolism ; beta-Galactosidase - urine ; beta-N-Acetylhexosaminidases - blood ; beta-N-Acetylhexosaminidases - metabolism ; beta-N-Acetylhexosaminidases - urine ; Cancer ; Case-Control Studies ; Chains ; Female ; Glycoconjugates ; Glycoconjugates - metabolism ; Glycoconjugates - urine ; Glycolipids ; Glycoproteins ; Glycosaminoglycans ; Glycoside Hydrolases - blood ; Glycoside Hydrolases - urine ; Golgi apparatus ; Humans ; Lysosomes ; Lysosomes - enzymology ; Lysosomes - metabolism ; Male ; Mannosidase ; Middle Aged ; Neoplasia ; Neoplasms ; Oligosaccharides ; Pancreas ; Pancreatic cancer ; Pancreatic Neoplasms - blood ; Pancreatic Neoplasms - enzymology ; Pancreatic Neoplasms - urine ; Sensitivity and Specificity ; Serum - enzymology ; Serum - metabolism ; Sugar ; Urine</subject><ispartof>Folia histochemica et cytobiologica, 2010-09, Vol.48 (3), p.351-357</ispartof><rights>2010. 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Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright Folia Histochemica et Cytobiologica Sep 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-e142bb7ac8b15ba41b421b31408c1d1a18f92ddb16c7952ba8b5a9d406e0d2153</citedby><cites>FETCH-LOGICAL-c355t-e142bb7ac8b15ba41b421b31408c1d1a18f92ddb16c7952ba8b5a9d406e0d2153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,860,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21071338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dariusz Szajda, Sławomir</creatorcontrib><creatorcontrib>Waszkiewicz, Napoleon</creatorcontrib><creatorcontrib>Stypułkowska, Anna</creatorcontrib><creatorcontrib>Dadan, Jacek</creatorcontrib><creatorcontrib>Zwierz, Krzysztof</creatorcontrib><title>Lysosomal exoglycosidases in serum and urine of patients with pancreatic adenocarcinoma</title><title>Folia histochemica et cytobiologica</title><addtitle>Folia Histochem Cytobiol</addtitle><description>Lysosomal exoglycosidases: N-acetyl-β-D-hexosaminidase (HEX), β-D-galactosidase (GAL), α-L-fucosidase (FUC) and α-D-mannosidase (MAN) modify oligosaccharide chains of glycoconjugates in endoplasmatic reticulum and/or Golgi apparatus and degrade them in lysosomes. In acid environment of lysosome, exoglycosidases degrade oligosaccharide chains of glycoproteins, glycolipids and glycosaminoglycans by eliminating single sugars from the edges of oligosaccharide chains. Neoplasms change biochemical processes in tissues and may significantly change the activity of many enzymes including the activity of lysosomal exoglycosidasses in serum and urine of persons with neoplasmatic diseases. The aim of the present paper was evaluation the activity of HEX, GAL, FUC and MAN in serum and urine of patients with pancreatic adenocarcinoma. Serum and urine samples were collected from 15 patients with adenocarcinoma of the pancreas and 15 healthy persons. The activity of lysosomal exoglycosidases was determined by the method of Marciniak et al. adapted to serum and urine of patients with adenocarcinoma of the pancreas. Our results indicate significant decrease in activity of GAL (p=0.037) in serum of patients with pancreatic adenocarcinoma, significant increase in activity of HEX (p<0.001) and FUC (p=0.027) in serum, and HEX (p=0.003) in urine, as well as significant decrease of FUC (p=0.016) and MAN (p=0.029) in urine o patients with adenocarcinoma of the pancreas, in comparison to the control group. Increase in activity of some lysosomal enzymes in serum and urine of pancreatic adenocarcinoma patients, may indicate on destruction of pancreatic tissue by pancreatic adenocarcinoma. Determination of the HEX, GAL, FUC and MAN in serum and urine may be useful in diagnostics of pancreatic adenocarcinoma.</description><subject>Adenocarcinoma</subject><subject>Adenocarcinoma - blood</subject><subject>Adenocarcinoma - enzymology</subject><subject>Adenocarcinoma - urine</subject><subject>Adult</subject><subject>Aged</subject><subject>alpha-L-Fucosidase - metabolism</subject><subject>alpha-L-Fucosidase - urine</subject><subject>alpha-Mannosidase - metabolism</subject><subject>beta-Galactosidase - metabolism</subject><subject>beta-Galactosidase - urine</subject><subject>beta-N-Acetylhexosaminidases - blood</subject><subject>beta-N-Acetylhexosaminidases - metabolism</subject><subject>beta-N-Acetylhexosaminidases - urine</subject><subject>Cancer</subject><subject>Case-Control Studies</subject><subject>Chains</subject><subject>Female</subject><subject>Glycoconjugates</subject><subject>Glycoconjugates - metabolism</subject><subject>Glycoconjugates - urine</subject><subject>Glycolipids</subject><subject>Glycoproteins</subject><subject>Glycosaminoglycans</subject><subject>Glycoside Hydrolases - blood</subject><subject>Glycoside Hydrolases - urine</subject><subject>Golgi apparatus</subject><subject>Humans</subject><subject>Lysosomes</subject><subject>Lysosomes - enzymology</subject><subject>Lysosomes - metabolism</subject><subject>Male</subject><subject>Mannosidase</subject><subject>Middle Aged</subject><subject>Neoplasia</subject><subject>Neoplasms</subject><subject>Oligosaccharides</subject><subject>Pancreas</subject><subject>Pancreatic cancer</subject><subject>Pancreatic Neoplasms - blood</subject><subject>Pancreatic Neoplasms - enzymology</subject><subject>Pancreatic Neoplasms - urine</subject><subject>Sensitivity and Specificity</subject><subject>Serum - enzymology</subject><subject>Serum - metabolism</subject><subject>Sugar</subject><subject>Urine</subject><issn>0239-8508</issn><issn>1897-5631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kctqHDEQRUWIicdOPiAbI-KFV51U6dEtLY1xHjDgjU2WQq9J2nRLY6k7zvy9exjHi4BXRRXnXgoOIR8RPjPRqS9_EECwBhAagBYa_YasUOmukS3Ht2QFjOtGSVDH5KTWewDZgsB35JghdMi5WpGf613NNY92oPFv_jXsfK59sDVW2idaY5lHalOgc-lTpHlDt3bqY5oqfeyn38uWfInLyVMbYsreFt-npe49OdrYocYPz_OU3H29vr363qxvvv24ulw3nks5NREFc66zXjmUzgp0gqHjKEB5DGhRbTQLwWHrOy2Zs8pJq4OANkJgKPkpuTj0bkt-mGOdzNhXH4fBppjnahQy5ELqbiE__Ufe57mk5bkFahVoEHvo_DWItZopaBH1QuGB8iXXWuLGbEs_2rIzCGZvxhzMmMWM2Zsx-8zZc_PsxhheEv9U8Cd8WYiq</recordid><startdate>20100930</startdate><enddate>20100930</enddate><creator>Dariusz Szajda, Sławomir</creator><creator>Waszkiewicz, Napoleon</creator><creator>Stypułkowska, Anna</creator><creator>Dadan, Jacek</creator><creator>Zwierz, Krzysztof</creator><general>Wydawnictwo Via Medica</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TO</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20100930</creationdate><title>Lysosomal exoglycosidases in serum and urine of patients with pancreatic adenocarcinoma</title><author>Dariusz Szajda, Sławomir ; Waszkiewicz, Napoleon ; Stypułkowska, Anna ; Dadan, Jacek ; Zwierz, Krzysztof</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-e142bb7ac8b15ba41b421b31408c1d1a18f92ddb16c7952ba8b5a9d406e0d2153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adenocarcinoma</topic><topic>Adenocarcinoma - 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Academic</collection><jtitle>Folia histochemica et cytobiologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dariusz Szajda, Sławomir</au><au>Waszkiewicz, Napoleon</au><au>Stypułkowska, Anna</au><au>Dadan, Jacek</au><au>Zwierz, Krzysztof</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lysosomal exoglycosidases in serum and urine of patients with pancreatic adenocarcinoma</atitle><jtitle>Folia histochemica et cytobiologica</jtitle><addtitle>Folia Histochem Cytobiol</addtitle><date>2010-09-30</date><risdate>2010</risdate><volume>48</volume><issue>3</issue><spage>351</spage><epage>357</epage><pages>351-357</pages><issn>0239-8508</issn><eissn>1897-5631</eissn><abstract>Lysosomal exoglycosidases: N-acetyl-β-D-hexosaminidase (HEX), β-D-galactosidase (GAL), α-L-fucosidase (FUC) and α-D-mannosidase (MAN) modify oligosaccharide chains of glycoconjugates in endoplasmatic reticulum and/or Golgi apparatus and degrade them in lysosomes. In acid environment of lysosome, exoglycosidases degrade oligosaccharide chains of glycoproteins, glycolipids and glycosaminoglycans by eliminating single sugars from the edges of oligosaccharide chains. Neoplasms change biochemical processes in tissues and may significantly change the activity of many enzymes including the activity of lysosomal exoglycosidasses in serum and urine of persons with neoplasmatic diseases. The aim of the present paper was evaluation the activity of HEX, GAL, FUC and MAN in serum and urine of patients with pancreatic adenocarcinoma. Serum and urine samples were collected from 15 patients with adenocarcinoma of the pancreas and 15 healthy persons. The activity of lysosomal exoglycosidases was determined by the method of Marciniak et al. adapted to serum and urine of patients with adenocarcinoma of the pancreas. Our results indicate significant decrease in activity of GAL (p=0.037) in serum of patients with pancreatic adenocarcinoma, significant increase in activity of HEX (p<0.001) and FUC (p=0.027) in serum, and HEX (p=0.003) in urine, as well as significant decrease of FUC (p=0.016) and MAN (p=0.029) in urine o patients with adenocarcinoma of the pancreas, in comparison to the control group. Increase in activity of some lysosomal enzymes in serum and urine of pancreatic adenocarcinoma patients, may indicate on destruction of pancreatic tissue by pancreatic adenocarcinoma. Determination of the HEX, GAL, FUC and MAN in serum and urine may be useful in diagnostics of pancreatic adenocarcinoma.</abstract><cop>Poland</cop><pub>Wydawnictwo Via Medica</pub><pmid>21071338</pmid><doi>10.2478/v10042-010-0060-9</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adenocarcinoma Adenocarcinoma - blood Adenocarcinoma - enzymology Adenocarcinoma - urine Adult Aged alpha-L-Fucosidase - metabolism alpha-L-Fucosidase - urine alpha-Mannosidase - metabolism beta-Galactosidase - metabolism beta-Galactosidase - urine beta-N-Acetylhexosaminidases - blood beta-N-Acetylhexosaminidases - metabolism beta-N-Acetylhexosaminidases - urine Cancer Case-Control Studies Chains Female Glycoconjugates Glycoconjugates - metabolism Glycoconjugates - urine Glycolipids Glycoproteins Glycosaminoglycans Glycoside Hydrolases - blood Glycoside Hydrolases - urine Golgi apparatus Humans Lysosomes Lysosomes - enzymology Lysosomes - metabolism Male Mannosidase Middle Aged Neoplasia Neoplasms Oligosaccharides Pancreas Pancreatic cancer Pancreatic Neoplasms - blood Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - urine Sensitivity and Specificity Serum - enzymology Serum - metabolism Sugar Urine |
| title | Lysosomal exoglycosidases in serum and urine of patients with pancreatic adenocarcinoma |
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