Lysozyme Granules and Lysosome Structures in Cell Culture
I HAVE demonstrated that lysozyme from hen egg-white when added to cultures of tumoral and normal cells from humans and animals induced the appearance of granules in the cytoplasm, viewed both by light and electron microscopy 1,2 . Morphological and cytochemical tests were carried out in order to cl...
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| Veröffentlicht in: | Nature (London) 1966-12, Vol.212 (5067), p.1274-1275 |
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| creator | CALLERIO-BABUDIERI, DIRCE |
| description | I HAVE demonstrated that lysozyme from hen egg-white when added to cultures of tumoral and normal cells from humans and animals induced the appearance of granules in the cytoplasm, viewed both by light and electron microscopy
1,2
. Morphological and cytochemical tests were carried out in order to clarify the nature of these granules. The tests suggested that the intracellular structures which were connected with this phenomenon were the cytoplasmic organelles classified as lysosomes. This name was given by De Duve
et al.
to subcellular particles with well defined morphological and enzyme characteristics. Cytochemical reactions have shown that lysosomes contain many hydrolytic enzymes, soluble at an optimum acid
p
H. |
| doi_str_mv | 10.1038/2121274a0 |
| format | Article |
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1,2
. Morphological and cytochemical tests were carried out in order to clarify the nature of these granules. The tests suggested that the intracellular structures which were connected with this phenomenon were the cytoplasmic organelles classified as lysosomes. This name was given by De Duve
et al.
to subcellular particles with well defined morphological and enzyme characteristics. Cytochemical reactions have shown that lysosomes contain many hydrolytic enzymes, soluble at an optimum acid
p
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1,2
. Morphological and cytochemical tests were carried out in order to clarify the nature of these granules. The tests suggested that the intracellular structures which were connected with this phenomenon were the cytoplasmic organelles classified as lysosomes. This name was given by De Duve
et al.
to subcellular particles with well defined morphological and enzyme characteristics. Cytochemical reactions have shown that lysosomes contain many hydrolytic enzymes, soluble at an optimum acid
p
H.</description><subject>Cells, Cultured</subject><subject>Humanities and Social Sciences</subject><subject>letter</subject><subject>Lysosomes - metabolism</subject><subject>Microscopy, Electron</subject><subject>multidisciplinary</subject><subject>Muramidase - metabolism</subject><subject>Science</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1966</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkE1LAzEURYMotlYX_gGZnSiMvnzMJFnKoFUouFDXIZNJpGU-ajJZ1F9vhmpX8haBk8PlvYvQJYY7DFTcE5yGMw1HaI4ZL3NWCn6M5gBE5CBoOUNnIWwAoMCcnaIZwSCBcTFHcrULw_eus9nS6z62NmS6b7KJhiHRt9FHM0af-LrPKtu2WRXbCZyjE6fbYC9-3wX6eHp8r57z1evypXpY5YYwOebOkFqLBtfSiJrWIBuny7IxhnGcSNEwKxiFoqRCEEdrVjjLKDbOCMu4JnSBrve5Wz98RRtG1a2DSYvo3g4xKDEdX0jJk3mzN40fQvDWqa1fd9rvFAY1FaUORSX36jc11p1tDuZfM0m43QshffWf1qvNEH2fLv0n7QdRcm_l</recordid><startdate>19661210</startdate><enddate>19661210</enddate><creator>CALLERIO-BABUDIERI, DIRCE</creator><general>Nature Publishing Group UK</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19661210</creationdate><title>Lysozyme Granules and Lysosome Structures in Cell Culture</title><author>CALLERIO-BABUDIERI, DIRCE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c249t-fc2ba8d1b9c8b3b09dfa66dcc471c8b5d4e8430563882f3b45fe431cfc8e47a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1966</creationdate><topic>Cells, Cultured</topic><topic>Humanities and Social Sciences</topic><topic>letter</topic><topic>Lysosomes - metabolism</topic><topic>Microscopy, Electron</topic><topic>multidisciplinary</topic><topic>Muramidase - metabolism</topic><topic>Science</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>CALLERIO-BABUDIERI, DIRCE</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nature (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>CALLERIO-BABUDIERI, DIRCE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lysozyme Granules and Lysosome Structures in Cell Culture</atitle><jtitle>Nature (London)</jtitle><stitle>Nature</stitle><addtitle>Nature</addtitle><date>1966-12-10</date><risdate>1966</risdate><volume>212</volume><issue>5067</issue><spage>1274</spage><epage>1275</epage><pages>1274-1275</pages><issn>0028-0836</issn><eissn>1476-4687</eissn><abstract>I HAVE demonstrated that lysozyme from hen egg-white when added to cultures of tumoral and normal cells from humans and animals induced the appearance of granules in the cytoplasm, viewed both by light and electron microscopy
1,2
. Morphological and cytochemical tests were carried out in order to clarify the nature of these granules. The tests suggested that the intracellular structures which were connected with this phenomenon were the cytoplasmic organelles classified as lysosomes. This name was given by De Duve
et al.
to subcellular particles with well defined morphological and enzyme characteristics. Cytochemical reactions have shown that lysosomes contain many hydrolytic enzymes, soluble at an optimum acid
p
H.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>21090478</pmid><doi>10.1038/2121274a0</doi><tpages>2</tpages></addata></record> |
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| ispartof | Nature (London), 1966-12, Vol.212 (5067), p.1274-1275 |
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| language | eng |
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| source | MEDLINE; Nature; SpringerLink Journals - AutoHoldings |
| subjects | Cells, Cultured Humanities and Social Sciences letter Lysosomes - metabolism Microscopy, Electron multidisciplinary Muramidase - metabolism Science |
| title | Lysozyme Granules and Lysosome Structures in Cell Culture |
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