Arachidonate 5-lipoxygenase and its new inhibitors

The 5-lipoxygenases of guinea pig peritoneal polymorphonuclear leukocytes and of rat basophilic leukemia cells have been solubilized, purified partially by affinity chromatography, and shown to convert arachidonic acid principally to 5-hydroperoxy-6,8,11,14-eicosatetraenoic acid. The activity of bot...

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Veröffentlicht in:	Journal of allergy and clinical immunology 1984-01, Vol.74 (3), p.349-352
Hauptverfasser:	Yamamoto, Shozo, Yoshimoto, Tanihiro, Furukawa, Masayuki, Horie, Tokunaru, Watanabe-Kohno, Shigekatsu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonate Lipoxygenases Basophils - enzymology Benzoquinones Cell Line Flavones Flavonoids - pharmacology Guinea Pigs Kinetics Leukemia, Experimental - enzymology Lipoxygenase - isolation & purification Lipoxygenase Inhibitors Lung - enzymology Muscle Contraction - drug effects Neutrophils - enzymology Quinones - pharmacology Rats SRS-A - pharmacology
Online-Zugang:	Volltext
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