Effects of ascorbic and dehydroascorbic acid on the multiplication of tumor ascites cells in vitro
The effects of AA and DHA on ATP C+ cell multiplication in vitro were studied by measuring incorporation of 3H thymidine into DNA. The results obtained demonstrate that both AA and DHA have the same effects: they favor cell multiplication at low doses and inhibit it at high doses. Experiments carrie...
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| Veröffentlicht in: | Journal of cancer research and clinical oncology 1984-09, Vol.108 (2), p.230-232 |
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| container_end_page | 232 |
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| container_issue | 2 |
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| container_title | Journal of cancer research and clinical oncology |
| container_volume | 108 |
| creator | LIOTTI, F. S MENGHINI, A. R GUERRIERI, P TALESA, V BODO, M |
| description | The effects of AA and DHA on ATP C+ cell multiplication in vitro were studied by measuring incorporation of 3H thymidine into DNA. The results obtained demonstrate that both AA and DHA have the same effects: they favor cell multiplication at low doses and inhibit it at high doses. Experiments carried out with serial doses of both these substances revealed that AA is more efficient in determining both stimulating and inhibiting effects. The lesser efficiency of DHA may be attributed to its limited stability in culture medium. Studies on the effect of high doses of AA and DHA added to the culture medium in single or fractionated doses revealed that fractionated administration is more efficient in inhibiting cell multiplication than single administration. |
| doi_str_mv | 10.1007/bf00402472 |
| format | Article |
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Studies on the effect of high doses of AA and DHA added to the culture medium in single or fractionated doses revealed that fractionated administration is more efficient in inhibiting cell multiplication than single administration.</description><subject>Animals</subject><subject>Ascites - pathology</subject><subject>Ascorbic Acid - analogs & derivatives</subject><subject>Ascorbic Acid - metabolism</subject><subject>Ascorbic Acid - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Dehydroascorbic Acid - pharmacology</subject><subject>General aspects (metabolism, cell proliferation, established cell line...)</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Tumor cell</subject><subject>Tumors</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEFLAzEQhYMotVYv3oUcxIOwmkk2m92jllaFghc9L9lsQiO7m5pkhf57U1rraZh53zxmHkLXQB6AEPHYGEJyQnNBT9AUckYzYIyfoikBARmnUJyjixC-SOq5oBM0KXJBCK2mqFkYo1UM2Bksg3K-sQrLocWtXm9b7_5nyrbYDTiuNe7HLtpNZ5WMNo3Sahx753cGNuqAle66gO2Af2z07hKdGdkFfXWoM_S5XHzMX7PV-8vb_GmVKVrRmAmQhhgQLRci52VTaaOqhkkoypy0lElZQkkbyCtWtYJxVZQJok2hy0JyrtgM3e19N959jzrEurdhd4octBtDXQJNKQEk8H4PKu9C8NrUG2976bc1kHoXaP28_As0wTcH17HpdXtEDwkm_fagp-9lZ7wclA1HrAJS8bxkv5oHfL8</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>LIOTTI, F. 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Experiments carried out with serial doses of both these substances revealed that AA is more efficient in determining both stimulating and inhibiting effects. The lesser efficiency of DHA may be attributed to its limited stability in culture medium. Studies on the effect of high doses of AA and DHA added to the culture medium in single or fractionated doses revealed that fractionated administration is more efficient in inhibiting cell multiplication than single administration.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>6470029</pmid><doi>10.1007/bf00402472</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of cancer research and clinical oncology, 1984-09, Vol.108 (2), p.230-232 |
| issn | 0171-5216 1432-1335 |
| language | eng |
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| source | MEDLINE; SpringerLink (Online service) |
| subjects | Animals Ascites - pathology Ascorbic Acid - analogs & derivatives Ascorbic Acid - metabolism Ascorbic Acid - pharmacology Biological and medical sciences Cell Division - drug effects Dehydroascorbic Acid - pharmacology General aspects (metabolism, cell proliferation, established cell line...) Medical sciences Mice Mice, Inbred BALB C Neoplasms, Experimental - pathology Tumor cell Tumors |
| title | Effects of ascorbic and dehydroascorbic acid on the multiplication of tumor ascites cells in vitro |
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