Acute necrosis of the intestinal mucosa with high serum levels of diamine oxidase

A patient with acute necrosis of the intestinal mucosa and high serum diamine oxidase activity is described. The 71-year-old woman, with a history of hypertension and cardiovascular and peripheral arteriosclerotic disease, presented with acute epigastric pain, vomiting, and a deteriorating hemodynam...

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Veröffentlicht in:Digestive diseases and sciences 1984-09, Vol.29 (9), p.872-874
Hauptverfasser: BOUNOUS, G, ECHAVE, V, VOBECKY, S. J, NAVERT, H, WOLLIN, A
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container_end_page 874
container_issue 9
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container_title Digestive diseases and sciences
container_volume 29
creator BOUNOUS, G
ECHAVE, V
VOBECKY, S. J
NAVERT, H
WOLLIN, A
description A patient with acute necrosis of the intestinal mucosa and high serum diamine oxidase activity is described. The 71-year-old woman, with a history of hypertension and cardiovascular and peripheral arteriosclerotic disease, presented with acute epigastric pain, vomiting, and a deteriorating hemodynamic condition. Serum level of the intestinal enzyme diamine oxidase (DAO) obtained on admission, approximately 24 hr after the onset of symptoms, was 7.4 times above the normal value. An exploratory laparotomy performed 6 hr later revealed cyanosis and areas of transmural necrosis involving the entire small bowel. The bowel was not resected because of the extent of lesion. Thirty hours after the first sample was taken and 2 hr before death, the serum DAO level was only slightly above normal. It is suggested that this biochemical marker could provide a valuable tool for the early diagnosis of intestinal ischemia.
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subjects Acute Disease
Aged
Amine Oxidase (Copper-Containing) - blood
Biological and medical sciences
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Intestinal Mucosa - blood supply
Intestinal Mucosa - pathology
Ischemia - blood
Ischemia - diagnosis
Medical sciences
Necrosis - diagnosis
Other diseases. Semiology
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
title Acute necrosis of the intestinal mucosa with high serum levels of diamine oxidase
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