Genital warts and cervical cancer: IV. A colposcopic index for differentiating subclinical papillomaviral infection from cervical intraepithelial neoplasia
Five colposcopic signs (thickness, color, contour, vascular atypia, and iodine staining) were graded into three objective categories representing (1) subclinical papillomaviral infection, (2) lower-grade dysplasia, and (3) grade 3 cervical intraepithelial neoplasia. Seventy-two colposcopically diffe...
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Veröffentlicht in: | American journal of obstetrics and gynecology 1984-08, Vol.149 (8), p.815-823 |
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creator | Reid, Richard Stanhope, C.Robert Herschman, Barry R. Crum, Christopher P. Agronow, Samuel J. |
description | Five colposcopic signs (thickness, color, contour, vascular atypia, and iodine staining) were graded into three objective categories representing (1) subclinical papillomaviral infection, (2) lower-grade dysplasia, and (3) grade 3 cervical intraepithelial neoplasia. Seventy-two colposcopically different biopsy specimens (25 of subclinical papillomaviral infection and 18 of grade 1, 18 of grade 2, and 11 of grade 3 cervical intraepithelial neoplasia) were collected from 52 women and interpreted by validated, quantitative histologic analysis. Attempts to grade lesions by the prominence of the acetowhitening reaction or the mere presence of aberrant surface capillaries were unsuccessful. In contrast, each of five new colposcopic criteria were significantly correlated with histologic severity. Differences in color, vascular atypia, and iodine staining were more predictive than those of thickness and contour. Combined into a weighted index, these colposcopic features were 96% correct in forecasting approximate histologic findings. Because this method relies upon critical analysis rather than pattern recall, the use of this colposcopic index greatly simplifies the learning of colposcopy. |
doi_str_mv | 10.1016/0002-9378(84)90597-0 |
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Seventy-two colposcopically different biopsy specimens (25 of subclinical papillomaviral infection and 18 of grade 1, 18 of grade 2, and 11 of grade 3 cervical intraepithelial neoplasia) were collected from 52 women and interpreted by validated, quantitative histologic analysis. Attempts to grade lesions by the prominence of the acetowhitening reaction or the mere presence of aberrant surface capillaries were unsuccessful. In contrast, each of five new colposcopic criteria were significantly correlated with histologic severity. Differences in color, vascular atypia, and iodine staining were more predictive than those of thickness and contour. Combined into a weighted index, these colposcopic features were 96% correct in forecasting approximate histologic findings. Because this method relies upon critical analysis rather than pattern recall, the use of this colposcopic index greatly simplifies the learning of colposcopy.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(84)90597-0</identifier><identifier>PMID: 6205589</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Biopsy ; Cervix Uteri - pathology ; Colposcopy ; Diagnosis, Differential ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Iodine ; Medical sciences ; Papillomaviridae ; Staining and Labeling ; Tumor Virus Infections - pathology ; Tumors ; Uterine Cervical Diseases - pathology ; Uterine Cervical Dysplasia - pathology ; Uterine Cervical Neoplasms - pathology ; Warts - pathology</subject><ispartof>American journal of obstetrics and gynecology, 1984-08, Vol.149 (8), p.815-823</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(84)90597-0$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9098946$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6205589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reid, Richard</creatorcontrib><creatorcontrib>Stanhope, C.Robert</creatorcontrib><creatorcontrib>Herschman, Barry R.</creatorcontrib><creatorcontrib>Crum, Christopher P.</creatorcontrib><creatorcontrib>Agronow, Samuel J.</creatorcontrib><title>Genital warts and cervical cancer: IV. A colposcopic index for differentiating subclinical papillomaviral infection from cervical intraepithelial neoplasia</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Five colposcopic signs (thickness, color, contour, vascular atypia, and iodine staining) were graded into three objective categories representing (1) subclinical papillomaviral infection, (2) lower-grade dysplasia, and (3) grade 3 cervical intraepithelial neoplasia. Seventy-two colposcopically different biopsy specimens (25 of subclinical papillomaviral infection and 18 of grade 1, 18 of grade 2, and 11 of grade 3 cervical intraepithelial neoplasia) were collected from 52 women and interpreted by validated, quantitative histologic analysis. Attempts to grade lesions by the prominence of the acetowhitening reaction or the mere presence of aberrant surface capillaries were unsuccessful. In contrast, each of five new colposcopic criteria were significantly correlated with histologic severity. Differences in color, vascular atypia, and iodine staining were more predictive than those of thickness and contour. Combined into a weighted index, these colposcopic features were 96% correct in forecasting approximate histologic findings. Because this method relies upon critical analysis rather than pattern recall, the use of this colposcopic index greatly simplifies the learning of colposcopy.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Cervix Uteri - pathology</subject><subject>Colposcopy</subject><subject>Diagnosis, Differential</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Iodine</subject><subject>Medical sciences</subject><subject>Papillomaviridae</subject><subject>Staining and Labeling</subject><subject>Tumor Virus Infections - pathology</subject><subject>Tumors</subject><subject>Uterine Cervical Diseases - pathology</subject><subject>Uterine Cervical Dysplasia - pathology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Warts - pathology</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkkFvFSEQx4mxqc_qN9CEgzF62ArsLgseTJpG2yZNvKhXMgusjmFhhX1P-1n8svLal3rsiRnmxwzznyHkBWennHH5jjEmGt0O6o3q3mrW66Fhj8iGs2pIJdVjsrlHnpCnpfzcu0KLY3IsBet7pTfk74WPuEKgvyGvhUJ01Pq8Q1uvLMRqv6dX307pGbUpLKnYtKClGJ3_Q6eUqcNp8tnHFWHF-J2W7WgDxtv3CywYQpphh7m6GCdvV0yRTjnN_8tgXDP4BdcfPmD1o09LgILwjBxNEIp_fjhPyNdPH7-cXzbXny-uzs-uGy9auTauBSYFZwOH2tYI4B3USM8t2G7Uou86IfvBial1QnHtO90rOaqhb90IVrQn5PVd3iWnX1tfVjNjsT4EqF_ZFqM410PLugdBXguxTuoKvjyA23H2ziwZZ8g35iB7jb86xKFUCaZclcZyj2mmle5kxT7cYb52v0OfTbHo61Ac5iqlcQkNZ2a_DWY_W7MftVGdud0Gw9p_kV2o0A</recordid><startdate>19840815</startdate><enddate>19840815</enddate><creator>Reid, Richard</creator><creator>Stanhope, C.Robert</creator><creator>Herschman, Barry R.</creator><creator>Crum, Christopher P.</creator><creator>Agronow, Samuel J.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19840815</creationdate><title>Genital warts and cervical cancer: IV. A colposcopic index for differentiating subclinical papillomaviral infection from cervical intraepithelial neoplasia</title><author>Reid, Richard ; Stanhope, C.Robert ; Herschman, Barry R. ; Crum, Christopher P. ; Agronow, Samuel J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e236t-d3a0621071a620baaedae2351cac4b925442657d2f3d2819e49586b8753dbac23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Cervix Uteri - pathology</topic><topic>Colposcopy</topic><topic>Diagnosis, Differential</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Iodine</topic><topic>Medical sciences</topic><topic>Papillomaviridae</topic><topic>Staining and Labeling</topic><topic>Tumor Virus Infections - pathology</topic><topic>Tumors</topic><topic>Uterine Cervical Diseases - pathology</topic><topic>Uterine Cervical Dysplasia - pathology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Warts - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Reid, Richard</creatorcontrib><creatorcontrib>Stanhope, C.Robert</creatorcontrib><creatorcontrib>Herschman, Barry R.</creatorcontrib><creatorcontrib>Crum, Christopher P.</creatorcontrib><creatorcontrib>Agronow, Samuel J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reid, Richard</au><au>Stanhope, C.Robert</au><au>Herschman, Barry R.</au><au>Crum, Christopher P.</au><au>Agronow, Samuel J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genital warts and cervical cancer: IV. A colposcopic index for differentiating subclinical papillomaviral infection from cervical intraepithelial neoplasia</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1984-08-15</date><risdate>1984</risdate><volume>149</volume><issue>8</issue><spage>815</spage><epage>823</epage><pages>815-823</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Five colposcopic signs (thickness, color, contour, vascular atypia, and iodine staining) were graded into three objective categories representing (1) subclinical papillomaviral infection, (2) lower-grade dysplasia, and (3) grade 3 cervical intraepithelial neoplasia. Seventy-two colposcopically different biopsy specimens (25 of subclinical papillomaviral infection and 18 of grade 1, 18 of grade 2, and 11 of grade 3 cervical intraepithelial neoplasia) were collected from 52 women and interpreted by validated, quantitative histologic analysis. Attempts to grade lesions by the prominence of the acetowhitening reaction or the mere presence of aberrant surface capillaries were unsuccessful. In contrast, each of five new colposcopic criteria were significantly correlated with histologic severity. Differences in color, vascular atypia, and iodine staining were more predictive than those of thickness and contour. Combined into a weighted index, these colposcopic features were 96% correct in forecasting approximate histologic findings. Because this method relies upon critical analysis rather than pattern recall, the use of this colposcopic index greatly simplifies the learning of colposcopy.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>6205589</pmid><doi>10.1016/0002-9378(84)90597-0</doi><tpages>9</tpages></addata></record> |
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subjects | Animals Biological and medical sciences Biopsy Cervix Uteri - pathology Colposcopy Diagnosis, Differential Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Iodine Medical sciences Papillomaviridae Staining and Labeling Tumor Virus Infections - pathology Tumors Uterine Cervical Diseases - pathology Uterine Cervical Dysplasia - pathology Uterine Cervical Neoplasms - pathology Warts - pathology |
title | Genital warts and cervical cancer: IV. A colposcopic index for differentiating subclinical papillomaviral infection from cervical intraepithelial neoplasia |
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