Prediction of relapse with the TRH test and prophylactic amitriptyline in 39 patients with endogenous depression
The authors conducted a double-blind prospective study of 39 patients with unipolar endogenous depression who recovered after ECT. Thyrotropin (TSH)-releasing hormone (TRH) tests were performed before and after ECT. Patients were divided into three groups on the basis of their altered TSH response:...
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| Veröffentlicht in: | The American journal of psychiatry 1984-08, Vol.141 (8), p.945-948 |
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| container_title | The American journal of psychiatry |
| container_volume | 141 |
| creator | Krog-Meyer, I Kirkegaard, C Kijne, B Lumholtz, B Smith, E Lykke-Olesen, L Bjørum, N |
| description | The authors conducted a double-blind prospective study of 39 patients
with unipolar endogenous depression who recovered after ECT. Thyrotropin
(TSH)-releasing hormone (TRH) tests were performed before and after ECT.
Patients were divided into three groups on the basis of their altered TSH
response: Persistent remission was predicted for patients in group 1 (N =
15) and relapse was predicted for groups 2A (N = 13) and 2B (N = 11).
Patients in groups 1 and 2A received placebo and those in group 2B received
amitriptyline for 6 months. Fewer relapses occurred in groups 1 and 2B than
in group 2A (p less than .05), showing that relapse can be predicted by the
TRH test and prevented by amitriptyline. |
| doi_str_mv | 10.1176/ajp.141.8.945 |
| format | Article |
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with unipolar endogenous depression who recovered after ECT. Thyrotropin
(TSH)-releasing hormone (TRH) tests were performed before and after ECT.
Patients were divided into three groups on the basis of their altered TSH
response: Persistent remission was predicted for patients in group 1 (N =
15) and relapse was predicted for groups 2A (N = 13) and 2B (N = 11).
Patients in groups 1 and 2A received placebo and those in group 2B received
amitriptyline for 6 months. Fewer relapses occurred in groups 1 and 2B than
in group 2A (p less than .05), showing that relapse can be predicted by the
TRH test and prevented by amitriptyline.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/ajp.141.8.945</identifier><identifier>PMID: 6431834</identifier><language>eng</language><publisher>United States: American Psychiatric Publishing</publisher><subject>Adult ; Aged ; Amitriptyline - therapeutic use ; Depressive Disorder - diagnosis ; Depressive Disorder - prevention & control ; Depressive Disorder - therapy ; Double-Blind Method ; Electroconvulsive Therapy ; Female ; Humans ; Male ; Middle Aged ; Outcome and Process Assessment (Health Care) ; Placebos ; Probability ; Prospective Studies ; Psychiatric Status Rating Scales ; Recurrence ; Thyrotropin - blood ; Thyrotropin-Releasing Hormone</subject><ispartof>The American journal of psychiatry, 1984-08, Vol.141 (8), p.945-948</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a351t-60d75b026d246e3fb87604b45c988717c641dd0e6b231aff5aea65cb8ec0da63</citedby><cites>FETCH-LOGICAL-a351t-60d75b026d246e3fb87604b45c988717c641dd0e6b231aff5aea65cb8ec0da63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/ajp.141.8.945$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/ajp.141.8.945$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,777,781,2846,21610,27850,27905,27906,77540,77541</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6431834$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Krog-Meyer, I</creatorcontrib><creatorcontrib>Kirkegaard, C</creatorcontrib><creatorcontrib>Kijne, B</creatorcontrib><creatorcontrib>Lumholtz, B</creatorcontrib><creatorcontrib>Smith, E</creatorcontrib><creatorcontrib>Lykke-Olesen, L</creatorcontrib><creatorcontrib>Bjørum, N</creatorcontrib><title>Prediction of relapse with the TRH test and prophylactic amitriptyline in 39 patients with endogenous depression</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>The authors conducted a double-blind prospective study of 39 patients
with unipolar endogenous depression who recovered after ECT. Thyrotropin
(TSH)-releasing hormone (TRH) tests were performed before and after ECT.
Patients were divided into three groups on the basis of their altered TSH
response: Persistent remission was predicted for patients in group 1 (N =
15) and relapse was predicted for groups 2A (N = 13) and 2B (N = 11).
Patients in groups 1 and 2A received placebo and those in group 2B received
amitriptyline for 6 months. Fewer relapses occurred in groups 1 and 2B than
in group 2A (p less than .05), showing that relapse can be predicted by the
TRH test and prevented by amitriptyline.</description><subject>Adult</subject><subject>Aged</subject><subject>Amitriptyline - therapeutic use</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - prevention & control</subject><subject>Depressive Disorder - therapy</subject><subject>Double-Blind Method</subject><subject>Electroconvulsive Therapy</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Outcome and Process Assessment (Health Care)</subject><subject>Placebos</subject><subject>Probability</subject><subject>Prospective Studies</subject><subject>Psychiatric Status Rating Scales</subject><subject>Recurrence</subject><subject>Thyrotropin - blood</subject><subject>Thyrotropin-Releasing Hormone</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>K30</sourceid><recordid>eNptkUFr3DAQhUVoSDZpjj0GBIUcAt5oLEuWjyWkTSHQUPaQm5CtcVeLV1YkLWH_fVV2CaUUHYSYT2_ezCPkE7AlQCvvzCYsoYGlWnaNOCELEFxUbV2rD2TBGKurTvCXc3KR0qY8GW_rM3ImGw6KNwsSniNaN2Q3ezqPNOJkQkL65vKa5jXS1c9HmjFlarylIc5hvZ9MwQdqti5HF_J-ch6p85R3NJjs0Od0-I_ezr_Qz7tELYaIKZUuH8npaKaEV8f7kqy-PqzuH6unH9--3395qgwXkCvJbCt6VktbNxL52KtWsqZvxNAp1UI7yAasZSj7moMZR2HQSDH0CgdmjeSX5OYgWzy_7soAeuvSgNNkPBZDWgF0opwCfv4H3My76Is1DRyYBGDAClUdqCHOKUUcdYhua-JeA9N_YtAlBl1i0EqXGAp_fVTd9Vu07_Rx76V-e6ibENxfHf8r9hteF5H-</recordid><startdate>198408</startdate><enddate>198408</enddate><creator>Krog-Meyer, I</creator><creator>Kirkegaard, C</creator><creator>Kijne, B</creator><creator>Lumholtz, B</creator><creator>Smith, E</creator><creator>Lykke-Olesen, L</creator><creator>Bjørum, N</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>HAWNG</scope><scope>HBMBR</scope><scope>IBDFT</scope><scope>K30</scope><scope>PAAUG</scope><scope>PAWHS</scope><scope>PAWZZ</scope><scope>PAXOH</scope><scope>PBHAV</scope><scope>PBQSW</scope><scope>PBYQZ</scope><scope>PCIWU</scope><scope>PCMID</scope><scope>PCZJX</scope><scope>PDGRG</scope><scope>PDWWI</scope><scope>PETMR</scope><scope>PFVGT</scope><scope>PGXDX</scope><scope>PIHIL</scope><scope>PISVA</scope><scope>PJCTQ</scope><scope>PJTMS</scope><scope>PLCHJ</scope><scope>PMHAD</scope><scope>PNQDJ</scope><scope>POUND</scope><scope>PPLAD</scope><scope>PQAPC</scope><scope>PQCAN</scope><scope>PQCMW</scope><scope>PQEME</scope><scope>PQHKH</scope><scope>PQMID</scope><scope>PQNCT</scope><scope>PQNET</scope><scope>PQSCT</scope><scope>PQSET</scope><scope>PSVJG</scope><scope>PVMQY</scope><scope>PZGFC</scope><scope>7X8</scope></search><sort><creationdate>198408</creationdate><title>Prediction of relapse with the TRH test and prophylactic amitriptyline in 39 patients with endogenous depression</title><author>Krog-Meyer, I ; Kirkegaard, C ; Kijne, B ; Lumholtz, B ; Smith, E ; Lykke-Olesen, L ; Bjørum, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a351t-60d75b026d246e3fb87604b45c988717c641dd0e6b231aff5aea65cb8ec0da63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Amitriptyline - 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with unipolar endogenous depression who recovered after ECT. Thyrotropin
(TSH)-releasing hormone (TRH) tests were performed before and after ECT.
Patients were divided into three groups on the basis of their altered TSH
response: Persistent remission was predicted for patients in group 1 (N =
15) and relapse was predicted for groups 2A (N = 13) and 2B (N = 11).
Patients in groups 1 and 2A received placebo and those in group 2B received
amitriptyline for 6 months. Fewer relapses occurred in groups 1 and 2B than
in group 2A (p less than .05), showing that relapse can be predicted by the
TRH test and prevented by amitriptyline.</abstract><cop>United States</cop><pub>American Psychiatric Publishing</pub><pmid>6431834</pmid><doi>10.1176/ajp.141.8.945</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-953X |
| ispartof | The American journal of psychiatry, 1984-08, Vol.141 (8), p.945-948 |
| issn | 0002-953X 1535-7228 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81195959 |
| source | MEDLINE; Psychiatry Legacy Collection Online Journals 1844-1996; Periodicals Index Online |
| subjects | Adult Aged Amitriptyline - therapeutic use Depressive Disorder - diagnosis Depressive Disorder - prevention & control Depressive Disorder - therapy Double-Blind Method Electroconvulsive Therapy Female Humans Male Middle Aged Outcome and Process Assessment (Health Care) Placebos Probability Prospective Studies Psychiatric Status Rating Scales Recurrence Thyrotropin - blood Thyrotropin-Releasing Hormone |
| title | Prediction of relapse with the TRH test and prophylactic amitriptyline in 39 patients with endogenous depression |
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