Resistance of Gram-Negative Bacilli to Gentamicin
Strains of Pseudomonas aeruginosa resistant to gentamicin have appeared during three years of extensive use of this antibiotic in the Winnipeg General Hospital. During October and November of 1970, isolates of P. aeruginosa sensitive to gentamicin were recovered from 62 patients. Thirty-one of these...
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| Veröffentlicht in: | The Journal of infectious diseases 1971-12, Vol.124 (Supplement-1), p.S264-S270 |
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| container_end_page | S270 |
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| container_issue | Supplement-1 |
| container_start_page | S264 |
| container_title | The Journal of infectious diseases |
| container_volume | 124 |
| creator | Snelling, Charles F. T. Ronald, Allan R. Cates, Claudette Y. Forsythe, William C. |
| description | Strains of Pseudomonas aeruginosa resistant to gentamicin have appeared during three years of extensive use of this antibiotic in the Winnipeg General Hospital. During October and November of 1970, isolates of P. aeruginosa sensitive to gentamicin were recovered from 62 patients. Thirty-one of these patients received gentamicin; in five patients, strains of P. aeruginosa resistant to gentamicin were isolated after therapy. Four patients received gentamicin parenterally, and one topically. No gentamicin-resistant P. aeruginosa appeared in the 31 patients not given gentamicin. Only two of 622 isolates of Enterobacteriaceae were resistant. Of 108 burns treated between October, 1968 and December, 1970 with daily prophylactic topical applications of gentamicin, 24 were colonized with P. aeruginosa; the organisms in seven patients were initially resistant. Pyocine typing on all resistant organisms from both groups of patients suggests that episodes of cross-infection with gentamicin-resistant strains have occurred in patients with burns. No persisting hospital reservoir of gentamicin-resistant organisms has been identified. |
| doi_str_mv | 10.1093/infdis/124.Supplement_1.S264 |
| format | Article |
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T. ; Ronald, Allan R. ; Cates, Claudette Y. ; Forsythe, William C.</creator><creatorcontrib>Snelling, Charles F. T. ; Ronald, Allan R. ; Cates, Claudette Y. ; Forsythe, William C.</creatorcontrib><description>Strains of Pseudomonas aeruginosa resistant to gentamicin have appeared during three years of extensive use of this antibiotic in the Winnipeg General Hospital. During October and November of 1970, isolates of P. aeruginosa sensitive to gentamicin were recovered from 62 patients. Thirty-one of these patients received gentamicin; in five patients, strains of P. aeruginosa resistant to gentamicin were isolated after therapy. Four patients received gentamicin parenterally, and one topically. No gentamicin-resistant P. aeruginosa appeared in the 31 patients not given gentamicin. Only two of 622 isolates of Enterobacteriaceae were resistant. Of 108 burns treated between October, 1968 and December, 1970 with daily prophylactic topical applications of gentamicin, 24 were colonized with P. aeruginosa; the organisms in seven patients were initially resistant. Pyocine typing on all resistant organisms from both groups of patients suggests that episodes of cross-infection with gentamicin-resistant strains have occurred in patients with burns. No persisting hospital reservoir of gentamicin-resistant organisms has been identified.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/124.Supplement_1.S264</identifier><identifier>PMID: 5001625</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Agar ; Antibiotics ; Burns ; Burns - drug therapy ; Cream ; Cross Infection - prevention & control ; Drug Resistance ; Enterobacteriaceae ; Enterobacteriaceae - drug effects ; Gentamicins - administration & dosage ; Gentamicins - pharmacology ; Gentamicins - therapeutic use ; Humans ; Infections ; Labor standards ; Microbial colonization ; Pseudomonas ; Pseudomonas aeruginosa ; Pseudomonas aeruginosa - drug effects ; Pseudomonas aeruginosa - isolation & purification ; Pseudomonas Infections - drug therapy ; Session VI: Clinical Experience</subject><ispartof>The Journal of infectious diseases, 1971-12, Vol.124 (Supplement-1), p.S264-S270</ispartof><rights>Copyright 1971 University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-6b545ec80ff207eb3fb18dac3b0924099898500c07d7ea851c654023066027c83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30110860$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30110860$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,27903,27904,57995,58228</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5001625$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Snelling, Charles F. T.</creatorcontrib><creatorcontrib>Ronald, Allan R.</creatorcontrib><creatorcontrib>Cates, Claudette Y.</creatorcontrib><creatorcontrib>Forsythe, William C.</creatorcontrib><title>Resistance of Gram-Negative Bacilli to Gentamicin</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>Strains of Pseudomonas aeruginosa resistant to gentamicin have appeared during three years of extensive use of this antibiotic in the Winnipeg General Hospital. During October and November of 1970, isolates of P. aeruginosa sensitive to gentamicin were recovered from 62 patients. Thirty-one of these patients received gentamicin; in five patients, strains of P. aeruginosa resistant to gentamicin were isolated after therapy. Four patients received gentamicin parenterally, and one topically. No gentamicin-resistant P. aeruginosa appeared in the 31 patients not given gentamicin. Only two of 622 isolates of Enterobacteriaceae were resistant. Of 108 burns treated between October, 1968 and December, 1970 with daily prophylactic topical applications of gentamicin, 24 were colonized with P. aeruginosa; the organisms in seven patients were initially resistant. Pyocine typing on all resistant organisms from both groups of patients suggests that episodes of cross-infection with gentamicin-resistant strains have occurred in patients with burns. No persisting hospital reservoir of gentamicin-resistant organisms has been identified.</description><subject>Agar</subject><subject>Antibiotics</subject><subject>Burns</subject><subject>Burns - drug therapy</subject><subject>Cream</subject><subject>Cross Infection - prevention & control</subject><subject>Drug Resistance</subject><subject>Enterobacteriaceae</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Gentamicins - administration & dosage</subject><subject>Gentamicins - pharmacology</subject><subject>Gentamicins - therapeutic use</subject><subject>Humans</subject><subject>Infections</subject><subject>Labor standards</subject><subject>Microbial colonization</subject><subject>Pseudomonas</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - drug effects</subject><subject>Pseudomonas aeruginosa - isolation & purification</subject><subject>Pseudomonas Infections - drug therapy</subject><subject>Session VI: Clinical Experience</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMlKA0EQhhtRNC6PIMxBvE1S1dv0gBeNJpG4gAuIl6an0yMdZ4nTE9G3dyQheqrDV3_9xUfICUIfIWUDX-UzHwZIef9xuVgUrnRVq7H_SCXfIj0ULImlRLZNegCUxqjSdI_shzAHAM5kskt2BQBKKnoEH1zwoTWVdVGdR-PGlPGdezOt_3TRhbG-KHzU1tG46zClt746JDu5KYI7Ws8D8jy6ehpO4pv78fXw_Ca2nKs2lpngwlkFeU4hcRnLM1QzY1kGKeWQpipV3RcWklnijBJopeBAGUgJNLGKHZDT1d1FU38sXWh16YN1RWEqVy-DVoip4Ei7xbPVom3qEBqX60XjS9N8awT9a0yvjOnOmP5vTP8a6-LH655lVrrZJrxW9Mfnoa2bDWaACEpCx-MV7zS6rw03zbuWCUuEnry8ajUeXd4Op1M9ZT8J14Rn</recordid><startdate>197112</startdate><enddate>197112</enddate><creator>Snelling, Charles F. T.</creator><creator>Ronald, Allan R.</creator><creator>Cates, Claudette Y.</creator><creator>Forsythe, William C.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197112</creationdate><title>Resistance of Gram-Negative Bacilli to Gentamicin</title><author>Snelling, Charles F. T. ; Ronald, Allan R. ; Cates, Claudette Y. ; Forsythe, William C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-6b545ec80ff207eb3fb18dac3b0924099898500c07d7ea851c654023066027c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Agar</topic><topic>Antibiotics</topic><topic>Burns</topic><topic>Burns - drug therapy</topic><topic>Cream</topic><topic>Cross Infection - prevention & control</topic><topic>Drug Resistance</topic><topic>Enterobacteriaceae</topic><topic>Enterobacteriaceae - drug effects</topic><topic>Gentamicins - administration & dosage</topic><topic>Gentamicins - pharmacology</topic><topic>Gentamicins - therapeutic use</topic><topic>Humans</topic><topic>Infections</topic><topic>Labor standards</topic><topic>Microbial colonization</topic><topic>Pseudomonas</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - drug effects</topic><topic>Pseudomonas aeruginosa - isolation & purification</topic><topic>Pseudomonas Infections - drug therapy</topic><topic>Session VI: Clinical Experience</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Snelling, Charles F. T.</creatorcontrib><creatorcontrib>Ronald, Allan R.</creatorcontrib><creatorcontrib>Cates, Claudette Y.</creatorcontrib><creatorcontrib>Forsythe, William C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Snelling, Charles F. T.</au><au>Ronald, Allan R.</au><au>Cates, Claudette Y.</au><au>Forsythe, William C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistance of Gram-Negative Bacilli to Gentamicin</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1971-12</date><risdate>1971</risdate><volume>124</volume><issue>Supplement-1</issue><spage>S264</spage><epage>S270</epage><pages>S264-S270</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>Strains of Pseudomonas aeruginosa resistant to gentamicin have appeared during three years of extensive use of this antibiotic in the Winnipeg General Hospital. During October and November of 1970, isolates of P. aeruginosa sensitive to gentamicin were recovered from 62 patients. Thirty-one of these patients received gentamicin; in five patients, strains of P. aeruginosa resistant to gentamicin were isolated after therapy. Four patients received gentamicin parenterally, and one topically. No gentamicin-resistant P. aeruginosa appeared in the 31 patients not given gentamicin. Only two of 622 isolates of Enterobacteriaceae were resistant. Of 108 burns treated between October, 1968 and December, 1970 with daily prophylactic topical applications of gentamicin, 24 were colonized with P. aeruginosa; the organisms in seven patients were initially resistant. Pyocine typing on all resistant organisms from both groups of patients suggests that episodes of cross-infection with gentamicin-resistant strains have occurred in patients with burns. No persisting hospital reservoir of gentamicin-resistant organisms has been identified.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>5001625</pmid><doi>10.1093/infdis/124.Supplement_1.S264</doi></addata></record> |
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| ispartof | The Journal of infectious diseases, 1971-12, Vol.124 (Supplement-1), p.S264-S270 |
| issn | 0022-1899 1537-6613 |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Agar Antibiotics Burns Burns - drug therapy Cream Cross Infection - prevention & control Drug Resistance Enterobacteriaceae Enterobacteriaceae - drug effects Gentamicins - administration & dosage Gentamicins - pharmacology Gentamicins - therapeutic use Humans Infections Labor standards Microbial colonization Pseudomonas Pseudomonas aeruginosa Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - isolation & purification Pseudomonas Infections - drug therapy Session VI: Clinical Experience |
| title | Resistance of Gram-Negative Bacilli to Gentamicin |
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