Usefulness of liposomes carrying losefamate for CT opacification of liver and spleen
Losefamate, a hepatobiliary contrast agent, was encapsulated into liposomes to increase its ability to opacify the liver and spleen on computed tomographic (CT) images. Multilamellar lipid vesicles (lecithin, cholesterol, and stearylamine, in 4:1:1 molar ratio) containing iosefamate in their aqueous...
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| Veröffentlicht in: | AJR, Am. J. Roentgenol.; (United States) Am. J. Roentgenol.; (United States), 1984-09, Vol.143 (3), p.575-579 |
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| container_title | AJR, Am. J. Roentgenol.; (United States) |
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| creator | Seltzer, SE Shulkin, PM Adams, DF Davis, MA Hoey, GB Hopkins, RM Bosworth, ME |
| description | Losefamate, a hepatobiliary contrast agent, was encapsulated into liposomes to increase its ability to opacify the liver and spleen on computed tomographic (CT) images. Multilamellar lipid vesicles (lecithin, cholesterol, and stearylamine, in 4:1:1 molar ratio) containing iosefamate in their aqueous phase were prepared. Seven dogs received intravenous injections of 100-300 mg I/kg in one of three forms: encapsulated, unencapsulated, or a mixture of the two in equal parts. Animals that received the opaque vesicles had marked opacification of their livers, bile ducts, gallbladders, spleens (maximum 106 H enhancement), and gastrointestinal tracts. Spleen CT values (an indicator of encapsulated material uptake) were always higher in these dogs than in the animals receiving equivalent amounts of unencapsulated iosefamate alone. At the high-dose level, liver uptake of the encapsulated materials was also greater. Liposome-encapsulated hepatobiliary contrast agents are effective liver and spleen opacifiers for CT imaging in the dog. |
| doi_str_mv | 10.2214/ajr.143.3.575 |
| format | Article |
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Multilamellar lipid vesicles (lecithin, cholesterol, and stearylamine, in 4:1:1 molar ratio) containing iosefamate in their aqueous phase were prepared. Seven dogs received intravenous injections of 100-300 mg I/kg in one of three forms: encapsulated, unencapsulated, or a mixture of the two in equal parts. Animals that received the opaque vesicles had marked opacification of their livers, bile ducts, gallbladders, spleens (maximum 106 H enhancement), and gastrointestinal tracts. Spleen CT values (an indicator of encapsulated material uptake) were always higher in these dogs than in the animals receiving equivalent amounts of unencapsulated iosefamate alone. At the high-dose level, liver uptake of the encapsulated materials was also greater. Liposome-encapsulated hepatobiliary contrast agents are effective liver and spleen opacifiers for CT imaging in the dog.</description><identifier>ISSN: 0361-803X</identifier><identifier>EISSN: 1546-3141</identifier><identifier>DOI: 10.2214/ajr.143.3.575</identifier><identifier>PMID: 6331738</identifier><language>eng</language><publisher>United States: Am Roentgen Ray Soc</publisher><subject>550602 - Medicine- External Radiation in Diagnostics- (1980-) ; ANIMALS ; BODY ; CELL CONSTITUENTS ; COMPUTERIZED TOMOGRAPHY ; CONTRAST MEDIA ; DIAGNOSTIC TECHNIQUES ; DIGESTIVE SYSTEM ; DOGS ; ENCAPSULATION ; GLANDS ; INJECTION ; INTAKE ; INTRAVENOUS INJECTION ; Iodipamide - analogs & derivatives ; LIPOSOMES ; LIVER ; Liver - diagnostic imaging ; MAMMALS ; OPACITY ; OPTICAL PROPERTIES ; ORGANOIDS ; ORGANS ; PHYSICAL PROPERTIES ; RADIOLOGY AND NUCLEAR MEDICINE ; SPLEEN ; Spleen - diagnostic imaging ; TOMOGRAPHY ; Tomography, X-Ray Computed ; VERTEBRATES</subject><ispartof>AJR, Am. J. 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J. Roentgenol.; (United States)</title><addtitle>AJR Am J Roentgenol</addtitle><description>Losefamate, a hepatobiliary contrast agent, was encapsulated into liposomes to increase its ability to opacify the liver and spleen on computed tomographic (CT) images. Multilamellar lipid vesicles (lecithin, cholesterol, and stearylamine, in 4:1:1 molar ratio) containing iosefamate in their aqueous phase were prepared. Seven dogs received intravenous injections of 100-300 mg I/kg in one of three forms: encapsulated, unencapsulated, or a mixture of the two in equal parts. Animals that received the opaque vesicles had marked opacification of their livers, bile ducts, gallbladders, spleens (maximum 106 H enhancement), and gastrointestinal tracts. Spleen CT values (an indicator of encapsulated material uptake) were always higher in these dogs than in the animals receiving equivalent amounts of unencapsulated iosefamate alone. At the high-dose level, liver uptake of the encapsulated materials was also greater. Liposome-encapsulated hepatobiliary contrast agents are effective liver and spleen opacifiers for CT imaging in the dog.</description><subject>550602 - Medicine- External Radiation in Diagnostics- (1980-)</subject><subject>ANIMALS</subject><subject>BODY</subject><subject>CELL CONSTITUENTS</subject><subject>COMPUTERIZED TOMOGRAPHY</subject><subject>CONTRAST MEDIA</subject><subject>DIAGNOSTIC TECHNIQUES</subject><subject>DIGESTIVE SYSTEM</subject><subject>DOGS</subject><subject>ENCAPSULATION</subject><subject>GLANDS</subject><subject>INJECTION</subject><subject>INTAKE</subject><subject>INTRAVENOUS INJECTION</subject><subject>Iodipamide - analogs & derivatives</subject><subject>LIPOSOMES</subject><subject>LIVER</subject><subject>Liver - diagnostic imaging</subject><subject>MAMMALS</subject><subject>OPACITY</subject><subject>OPTICAL PROPERTIES</subject><subject>ORGANOIDS</subject><subject>ORGANS</subject><subject>PHYSICAL PROPERTIES</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>SPLEEN</subject><subject>Spleen - diagnostic imaging</subject><subject>TOMOGRAPHY</subject><subject>Tomography, X-Ray Computed</subject><subject>VERTEBRATES</subject><issn>0361-803X</issn><issn>1546-3141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0L9rGzEYxnFRWlI3ydixIDp0O0c6_byxmKQtBLI4kE3olFexgu501XuuyX_fS22aSctHzwtfQj5ztm5bLq_8c11zKdZirYx6R1ZcSd0ILvl7smJC88Yy8fCRfEJ8ZowZ25kzcqaF4EbYFdneI8R9HgGRlkhzmgqWAZAGX-tLGp9oLovwg5-BxlLpZkvL5EOKKfg5lfH46w9U6sdHilMGGC_Ih-gzwuXpPSf3N9fbzc_m9u7Hr8332ya0xs5Nr7pgeiVi35uuB2kFxD6A5tqHEKXolNHcM-2NVkr6tjWtjKFTEkSIvQzinHw97hack8OQZgi7UMYRwuy0ZLZjdkHfjmiq5fcecHZDwgA5-xHKHp3l3Hb6H2yOMNSCWCG6qabB1xfHmXtN7ZbUbknthFtSL_7LaXjfD_D4X5_avh3epafdIVVwOPicF83d4XB4G_oLCxWH7g</recordid><startdate>198409</startdate><enddate>198409</enddate><creator>Seltzer, SE</creator><creator>Shulkin, PM</creator><creator>Adams, DF</creator><creator>Davis, MA</creator><creator>Hoey, GB</creator><creator>Hopkins, RM</creator><creator>Bosworth, ME</creator><general>Am Roentgen Ray Soc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>198409</creationdate><title>Usefulness of liposomes carrying losefamate for CT opacification of liver and spleen</title><author>Seltzer, SE ; Shulkin, PM ; Adams, DF ; Davis, MA ; Hoey, GB ; Hopkins, RM ; Bosworth, ME</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-b59c7b53fbb79be483efbce616accf4395761a06a76554a22724fc954e3cfb4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>550602 - Medicine- External Radiation in Diagnostics- (1980-)</topic><topic>ANIMALS</topic><topic>BODY</topic><topic>CELL CONSTITUENTS</topic><topic>COMPUTERIZED TOMOGRAPHY</topic><topic>CONTRAST MEDIA</topic><topic>DIAGNOSTIC TECHNIQUES</topic><topic>DIGESTIVE SYSTEM</topic><topic>DOGS</topic><topic>ENCAPSULATION</topic><topic>GLANDS</topic><topic>INJECTION</topic><topic>INTAKE</topic><topic>INTRAVENOUS INJECTION</topic><topic>Iodipamide - analogs & derivatives</topic><topic>LIPOSOMES</topic><topic>LIVER</topic><topic>Liver - diagnostic imaging</topic><topic>MAMMALS</topic><topic>OPACITY</topic><topic>OPTICAL PROPERTIES</topic><topic>ORGANOIDS</topic><topic>ORGANS</topic><topic>PHYSICAL PROPERTIES</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>SPLEEN</topic><topic>Spleen - diagnostic imaging</topic><topic>TOMOGRAPHY</topic><topic>Tomography, X-Ray Computed</topic><topic>VERTEBRATES</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seltzer, SE</creatorcontrib><creatorcontrib>Shulkin, PM</creatorcontrib><creatorcontrib>Adams, DF</creatorcontrib><creatorcontrib>Davis, MA</creatorcontrib><creatorcontrib>Hoey, GB</creatorcontrib><creatorcontrib>Hopkins, RM</creatorcontrib><creatorcontrib>Bosworth, ME</creatorcontrib><creatorcontrib>Harvard Medical School, Boston, MA</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>AJR, Am. J. Roentgenol.; (United States)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seltzer, SE</au><au>Shulkin, PM</au><au>Adams, DF</au><au>Davis, MA</au><au>Hoey, GB</au><au>Hopkins, RM</au><au>Bosworth, ME</au><aucorp>Harvard Medical School, Boston, MA</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Usefulness of liposomes carrying losefamate for CT opacification of liver and spleen</atitle><jtitle>AJR, Am. J. Roentgenol.; (United States)</jtitle><addtitle>AJR Am J Roentgenol</addtitle><date>1984-09</date><risdate>1984</risdate><volume>143</volume><issue>3</issue><spage>575</spage><epage>579</epage><pages>575-579</pages><issn>0361-803X</issn><eissn>1546-3141</eissn><abstract>Losefamate, a hepatobiliary contrast agent, was encapsulated into liposomes to increase its ability to opacify the liver and spleen on computed tomographic (CT) images. Multilamellar lipid vesicles (lecithin, cholesterol, and stearylamine, in 4:1:1 molar ratio) containing iosefamate in their aqueous phase were prepared. Seven dogs received intravenous injections of 100-300 mg I/kg in one of three forms: encapsulated, unencapsulated, or a mixture of the two in equal parts. Animals that received the opaque vesicles had marked opacification of their livers, bile ducts, gallbladders, spleens (maximum 106 H enhancement), and gastrointestinal tracts. Spleen CT values (an indicator of encapsulated material uptake) were always higher in these dogs than in the animals receiving equivalent amounts of unencapsulated iosefamate alone. At the high-dose level, liver uptake of the encapsulated materials was also greater. Liposome-encapsulated hepatobiliary contrast agents are effective liver and spleen opacifiers for CT imaging in the dog.</abstract><cop>United States</cop><pub>Am Roentgen Ray Soc</pub><pmid>6331738</pmid><doi>10.2214/ajr.143.3.575</doi><tpages>5</tpages></addata></record> |
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| source | American Roentgen Ray Society; MEDLINE; Alma/SFX Local Collection |
| subjects | 550602 - Medicine- External Radiation in Diagnostics- (1980-) ANIMALS BODY CELL CONSTITUENTS COMPUTERIZED TOMOGRAPHY CONTRAST MEDIA DIAGNOSTIC TECHNIQUES DIGESTIVE SYSTEM DOGS ENCAPSULATION GLANDS INJECTION INTAKE INTRAVENOUS INJECTION Iodipamide - analogs & derivatives LIPOSOMES LIVER Liver - diagnostic imaging MAMMALS OPACITY OPTICAL PROPERTIES ORGANOIDS ORGANS PHYSICAL PROPERTIES RADIOLOGY AND NUCLEAR MEDICINE SPLEEN Spleen - diagnostic imaging TOMOGRAPHY Tomography, X-Ray Computed VERTEBRATES |
| title | Usefulness of liposomes carrying losefamate for CT opacification of liver and spleen |
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