Cerebral blastomycosis: an immunodiagnostic study

Cerebral blastomycosis may simulate a brain tumor. Its diagnosis is sometimes very difficult. The morphologic identification of the fungus may be misleading because it shares some common features with many other dimorphic fungi. Culturing and conversion of the organism from mycelial phase to yeast p...

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Veröffentlicht in:American journal of clinical pathology 1984-08, Vol.82 (2), p.243-246
Hauptverfasser: TANG, T. T, MARSIK, F. J, HARB, J. M, WILLIAMS, J. E, FROMMELL, G. T, DUNN, D. K
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container_issue 2
container_start_page 243
container_title American journal of clinical pathology
container_volume 82
creator TANG, T. T
MARSIK, F. J
HARB, J. M
WILLIAMS, J. E
FROMMELL, G. T
DUNN, D. K
description Cerebral blastomycosis may simulate a brain tumor. Its diagnosis is sometimes very difficult. The morphologic identification of the fungus may be misleading because it shares some common features with many other dimorphic fungi. Culturing and conversion of the organism from mycelial phase to yeast phase are not always successful. Immunofluorescent staining of the biopsy tissue is useful in confirming the diagnosis. However, a combination of double immunodiffusion (DID) test and complement fixation (CF) test makes the diagnosis more accurate and reliable. The direct role of macrophages in defending the host against blastomycosis is illustrated by electron microscopy.
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subjects Antigens, Fungal - analysis
Biological and medical sciences
Blastomyces - immunology
Blastomyces - ultrastructure
Blastomycosis - diagnosis
Blastomycosis - pathology
Brain Abscess - diagnosis
Brain Abscess - pathology
Brain Neoplasms - diagnosis
Child
Diagnosis, Differential
Human mycoses
Humans
Infectious diseases
Male
Medical sciences
Miscellaneous mycoses
Mycoses
title Cerebral blastomycosis: an immunodiagnostic study
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