A Possible Pathogenic Role for Virus-Carrier Lymphocytes
The possibility that viruses are involved in the pathogenesis of aphthous lesions was investigated. Immunofluorescent-antibody tests showed that antigens of adenovirus and herpesvirus are present in cells from aphthous lesions and lymphocytes from persons with aphthae more frequently than in cells f...
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| Veröffentlicht in: | The Journal of infectious diseases 1971-08, Vol.124 (2), p.214-216 |
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| container_end_page | 216 |
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| container_issue | 2 |
| container_start_page | 214 |
| container_title | The Journal of infectious diseases |
| container_volume | 124 |
| creator | Nász, I. Kulcsár, Gizella Dán, P. Sallay, Kornéfia |
| description | The possibility that viruses are involved in the pathogenesis of aphthous lesions was investigated. Immunofluorescent-antibody tests showed that antigens of adenovirus and herpesvirus are present in cells from aphthous lesions and lymphocytes from persons with aphthae more frequently than in cells from normal persons. Antigens of adenovirus type 1 and herpesvirus caused blastogenic transformation in a significant proportion of lymphocytes from aphthous patients. The findings suggest that virus-carrier lymphocytes may be an important factor in the development of certain viral diseases. |
| doi_str_mv | 10.1093/infdis/124.2.214 |
| format | Article |
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Immunofluorescent-antibody tests showed that antigens of adenovirus and herpesvirus are present in cells from aphthous lesions and lymphocytes from persons with aphthae more frequently than in cells from normal persons. Antigens of adenovirus type 1 and herpesvirus caused blastogenic transformation in a significant proportion of lymphocytes from aphthous patients. The findings suggest that virus-carrier lymphocytes may be an important factor in the development of certain viral diseases.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/124.2.214</identifier><identifier>PMID: 4330999</identifier><language>eng</language><publisher>United States: The University of Chicago Press</publisher><subject>Adenoviridae - immunology ; Adenoviridae Infections - complications ; Adenoviruses ; Antigens ; Antigens, Viral ; Antiserum ; Aphthous stomatitis ; Epithelial cells ; Fluorescence ; Fluorescent Antibody Technique ; Herpesviridae ; Herpesviridae - immunology ; Herpesviridae Infections - complications ; Humans ; Lymphocytes ; Stomatitis, Aphthous - etiology ; Viral antigens ; Viruses</subject><ispartof>The Journal of infectious diseases, 1971-08, Vol.124 (2), p.214-216</ispartof><rights>Copyright 1971 University of Chicago</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c354t-e7b70eddf710963f47e534d10dc576f71e6f59c2f830f261255f62b00f1238003</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30108437$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30108437$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,780,784,803,27924,27925,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4330999$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nász, I.</creatorcontrib><creatorcontrib>Kulcsár, Gizella</creatorcontrib><creatorcontrib>Dán, P.</creatorcontrib><creatorcontrib>Sallay, Kornéfia</creatorcontrib><title>A Possible Pathogenic Role for Virus-Carrier Lymphocytes</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><description>The possibility that viruses are involved in the pathogenesis of aphthous lesions was investigated. Immunofluorescent-antibody tests showed that antigens of adenovirus and herpesvirus are present in cells from aphthous lesions and lymphocytes from persons with aphthae more frequently than in cells from normal persons. Antigens of adenovirus type 1 and herpesvirus caused blastogenic transformation in a significant proportion of lymphocytes from aphthous patients. The findings suggest that virus-carrier lymphocytes may be an important factor in the development of certain viral diseases.</description><subject>Adenoviridae - immunology</subject><subject>Adenoviridae Infections - complications</subject><subject>Adenoviruses</subject><subject>Antigens</subject><subject>Antigens, Viral</subject><subject>Antiserum</subject><subject>Aphthous stomatitis</subject><subject>Epithelial cells</subject><subject>Fluorescence</subject><subject>Fluorescent Antibody Technique</subject><subject>Herpesviridae</subject><subject>Herpesviridae - immunology</subject><subject>Herpesviridae Infections - complications</subject><subject>Humans</subject><subject>Lymphocytes</subject><subject>Stomatitis, Aphthous - etiology</subject><subject>Viral antigens</subject><subject>Viruses</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtPwzAMgCMEGmNw54LUE7duzqNJe0QTWxGTmHgJ7RL1kbCMdh1JK7F_T1CncbLsz7bsD6FrDGMMCZ2YrS6Nm2DCxmRMMDtBQxxREXKO6SkaAhAS4jhJztGFcxsAYJSLARowSiFJkiGK74Jl45zJKxUss3bdfKqtKYLnxue6scG7sZ0Lp5m1Rtlgsa9366bYt8pdojOdVU5dHeIIvc3uX6dpuHiaP0zvFmFBI9aGSuQCVFlq4e_lVDOhIspKDGURCe6riusoKYiOKWjCMYkizUkOoDGhMQAdodt-7842351yrayNK1RVZVvVdE7GGMcMOPGN0DcW1j9klZY7a-rM7iUG-SdL9rKklyWJ9LL8yM1hd5fXqjwOHOz8841rG3vEFDDEjArPw54b16qfI8_sl-SCikimHyu5enlcpelyJuf0F5pCffo</recordid><startdate>197108</startdate><enddate>197108</enddate><creator>Nász, I.</creator><creator>Kulcsár, Gizella</creator><creator>Dán, P.</creator><creator>Sallay, Kornéfia</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197108</creationdate><title>A Possible Pathogenic Role for Virus-Carrier Lymphocytes</title><author>Nász, I. ; Kulcsár, Gizella ; Dán, P. ; Sallay, Kornéfia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-e7b70eddf710963f47e534d10dc576f71e6f59c2f830f261255f62b00f1238003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Adenoviridae - immunology</topic><topic>Adenoviridae Infections - complications</topic><topic>Adenoviruses</topic><topic>Antigens</topic><topic>Antigens, Viral</topic><topic>Antiserum</topic><topic>Aphthous stomatitis</topic><topic>Epithelial cells</topic><topic>Fluorescence</topic><topic>Fluorescent Antibody Technique</topic><topic>Herpesviridae</topic><topic>Herpesviridae - immunology</topic><topic>Herpesviridae Infections - complications</topic><topic>Humans</topic><topic>Lymphocytes</topic><topic>Stomatitis, Aphthous - etiology</topic><topic>Viral antigens</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nász, I.</creatorcontrib><creatorcontrib>Kulcsár, Gizella</creatorcontrib><creatorcontrib>Dán, P.</creatorcontrib><creatorcontrib>Sallay, Kornéfia</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nász, I.</au><au>Kulcsár, Gizella</au><au>Dán, P.</au><au>Sallay, Kornéfia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Possible Pathogenic Role for Virus-Carrier Lymphocytes</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1971-08</date><risdate>1971</risdate><volume>124</volume><issue>2</issue><spage>214</spage><epage>216</epage><pages>214-216</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><abstract>The possibility that viruses are involved in the pathogenesis of aphthous lesions was investigated. Immunofluorescent-antibody tests showed that antigens of adenovirus and herpesvirus are present in cells from aphthous lesions and lymphocytes from persons with aphthae more frequently than in cells from normal persons. Antigens of adenovirus type 1 and herpesvirus caused blastogenic transformation in a significant proportion of lymphocytes from aphthous patients. The findings suggest that virus-carrier lymphocytes may be an important factor in the development of certain viral diseases.</abstract><cop>United States</cop><pub>The University of Chicago Press</pub><pmid>4330999</pmid><doi>10.1093/infdis/124.2.214</doi><tpages>3</tpages></addata></record> |
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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1971-08, Vol.124 (2), p.214-216 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Adenoviridae - immunology Adenoviridae Infections - complications Adenoviruses Antigens Antigens, Viral Antiserum Aphthous stomatitis Epithelial cells Fluorescence Fluorescent Antibody Technique Herpesviridae Herpesviridae - immunology Herpesviridae Infections - complications Humans Lymphocytes Stomatitis, Aphthous - etiology Viral antigens Viruses |
| title | A Possible Pathogenic Role for Virus-Carrier Lymphocytes |
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