The corticomotoneurone connection is normal in Parkinson's disease
Voluntary movements in Parkinson's disease are initiated and executed slowly 1,2 . It is assumed that the motor cortex and its output pathway are intact and that bradykinesia is due to abnormal motor commands delivered to a normal corticospinal system. We have tested this assumption using elect...
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| Veröffentlicht in: | Nature (London) 1984-08, Vol.310 (5976), p.407-409 |
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| container_title | Nature (London) |
| container_volume | 310 |
| creator | Dick, J. P. R Cowan, J. M. A Day, B. L Berardelli, A Kachi, T Rothwell, J. C Marsden, C. D |
| description | Voluntary movements in Parkinson's disease are initiated and executed slowly
1,2
. It is assumed that the motor cortex and its output pathway are intact and that bradykinesia is due to abnormal motor commands delivered to a normal corticospinal system. We have tested this assumption using electrical stimulation of the motor cortex through the scalp in three patients with severe Parkinson's disease, studied during fluctuations from relatively normal mobility when receiving drugs (ON) to severe bradykinesia when not receiving drugs (OFF). Thresholds and latencies for motor cortex stimulation to excite thumb flexor muscles and the resulting fast mechanical responses were the same in both ON and OFF conditions, even though the patients were unable to execute fast thumb flexion movements voluntarily when OFF. We conclude that the excitability and conduction velocity of the corticospinal motor pathways are normal in Parkinson's disease. |
| doi_str_mv | 10.1038/310407a0 |
| format | Article |
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1,2
. It is assumed that the motor cortex and its output pathway are intact and that bradykinesia is due to abnormal motor commands delivered to a normal corticospinal system. We have tested this assumption using electrical stimulation of the motor cortex through the scalp in three patients with severe Parkinson's disease, studied during fluctuations from relatively normal mobility when receiving drugs (ON) to severe bradykinesia when not receiving drugs (OFF). Thresholds and latencies for motor cortex stimulation to excite thumb flexor muscles and the resulting fast mechanical responses were the same in both ON and OFF conditions, even though the patients were unable to execute fast thumb flexion movements voluntarily when OFF. We conclude that the excitability and conduction velocity of the corticospinal motor pathways are normal in Parkinson's disease.</description><identifier>ISSN: 0028-0836</identifier><identifier>EISSN: 1476-4687</identifier><identifier>DOI: 10.1038/310407a0</identifier><identifier>PMID: 6462225</identifier><identifier>CODEN: NATUAS</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Adult ; Biological and medical sciences ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Dopamine - physiology ; Humanities and Social Sciences ; Humans ; letter ; Levodopa - therapeutic use ; Male ; Medical sciences ; Middle Aged ; Motor Cortex - physiopathology ; Movement ; multidisciplinary ; Neural Conduction ; Neurology ; Parkinson Disease - physiopathology ; Science ; Science (multidisciplinary)</subject><ispartof>Nature (London), 1984-08, Vol.310 (5976), p.407-409</ispartof><rights>Springer Nature Limited 1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2790-8b6d4b3e10cb141055a39c35395c613c0543d9011194f75f2381fdfbf1b153a3</citedby><cites>FETCH-LOGICAL-c2790-8b6d4b3e10cb141055a39c35395c613c0543d9011194f75f2381fdfbf1b153a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/310407a0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/310407a0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,2725,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8845256$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6462225$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dick, J. P. R</creatorcontrib><creatorcontrib>Cowan, J. M. A</creatorcontrib><creatorcontrib>Day, B. L</creatorcontrib><creatorcontrib>Berardelli, A</creatorcontrib><creatorcontrib>Kachi, T</creatorcontrib><creatorcontrib>Rothwell, J. C</creatorcontrib><creatorcontrib>Marsden, C. D</creatorcontrib><title>The corticomotoneurone connection is normal in Parkinson's disease</title><title>Nature (London)</title><addtitle>Nature</addtitle><addtitle>Nature</addtitle><description>Voluntary movements in Parkinson's disease are initiated and executed slowly
1,2
. It is assumed that the motor cortex and its output pathway are intact and that bradykinesia is due to abnormal motor commands delivered to a normal corticospinal system. We have tested this assumption using electrical stimulation of the motor cortex through the scalp in three patients with severe Parkinson's disease, studied during fluctuations from relatively normal mobility when receiving drugs (ON) to severe bradykinesia when not receiving drugs (OFF). Thresholds and latencies for motor cortex stimulation to excite thumb flexor muscles and the resulting fast mechanical responses were the same in both ON and OFF conditions, even though the patients were unable to execute fast thumb flexion movements voluntarily when OFF. We conclude that the excitability and conduction velocity of the corticospinal motor pathways are normal in Parkinson's disease.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases</subject><subject>Dopamine - physiology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>letter</subject><subject>Levodopa - therapeutic use</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Motor Cortex - physiopathology</subject><subject>Movement</subject><subject>multidisciplinary</subject><subject>Neural Conduction</subject><subject>Neurology</subject><subject>Parkinson Disease - physiopathology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><issn>0028-0836</issn><issn>1476-4687</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtOwzAQRS0EKqUg8QOgLBCPRWAmthNnCRUvqRIsuo8cxwGXxAY7WfD3GLV0xcYj-R7d0RxCjhGuEai4oQgMCgk7ZIqsyFOWi2KXTAEykYKg-T45CGEFABwLNiGTnOVZlvEpuVu-60Q5Pxjlejc4q0cfn_hlrVaDcTYxIbHO97JLjE1epf8wNjh7EZLGBC2DPiR7reyCPtrMGVk-3C_nT-ni5fF5frtIVVaUkIo6b1hNNYKqkSFwLmmpKKclVzlSBZzRpgRELFlb8DajAtumrVuskVNJZ-R8Xfvp3deow1D1JijdddJqN4ZKIIp4u4jg5RpU3oXgdVt9etNL_10hVL-2qj9bET3ZdI51r5stuNET87NNLoOSXeulVSZsMSEYz3gesas1FmJi37SvVm70Nsr4b-XpmrVyGL3edm2BHzBKhtQ</recordid><startdate>19840802</startdate><enddate>19840802</enddate><creator>Dick, J. P. R</creator><creator>Cowan, J. M. A</creator><creator>Day, B. L</creator><creator>Berardelli, A</creator><creator>Kachi, T</creator><creator>Rothwell, J. C</creator><creator>Marsden, C. D</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840802</creationdate><title>The corticomotoneurone connection is normal in Parkinson's disease</title><author>Dick, J. P. R ; Cowan, J. M. A ; Day, B. L ; Berardelli, A ; Kachi, T ; Rothwell, J. C ; Marsden, C. 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Prion diseases</topic><topic>Dopamine - physiology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>letter</topic><topic>Levodopa - therapeutic use</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Motor Cortex - physiopathology</topic><topic>Movement</topic><topic>multidisciplinary</topic><topic>Neural Conduction</topic><topic>Neurology</topic><topic>Parkinson Disease - physiopathology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dick, J. P. R</creatorcontrib><creatorcontrib>Cowan, J. M. A</creatorcontrib><creatorcontrib>Day, B. L</creatorcontrib><creatorcontrib>Berardelli, A</creatorcontrib><creatorcontrib>Kachi, T</creatorcontrib><creatorcontrib>Rothwell, J. C</creatorcontrib><creatorcontrib>Marsden, C. 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1,2
. It is assumed that the motor cortex and its output pathway are intact and that bradykinesia is due to abnormal motor commands delivered to a normal corticospinal system. We have tested this assumption using electrical stimulation of the motor cortex through the scalp in three patients with severe Parkinson's disease, studied during fluctuations from relatively normal mobility when receiving drugs (ON) to severe bradykinesia when not receiving drugs (OFF). Thresholds and latencies for motor cortex stimulation to excite thumb flexor muscles and the resulting fast mechanical responses were the same in both ON and OFF conditions, even though the patients were unable to execute fast thumb flexion movements voluntarily when OFF. We conclude that the excitability and conduction velocity of the corticospinal motor pathways are normal in Parkinson's disease.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>6462225</pmid><doi>10.1038/310407a0</doi><tpages>3</tpages></addata></record> |
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| ispartof | Nature (London), 1984-08, Vol.310 (5976), p.407-409 |
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| subjects | Adult Biological and medical sciences Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Dopamine - physiology Humanities and Social Sciences Humans letter Levodopa - therapeutic use Male Medical sciences Middle Aged Motor Cortex - physiopathology Movement multidisciplinary Neural Conduction Neurology Parkinson Disease - physiopathology Science Science (multidisciplinary) |
| title | The corticomotoneurone connection is normal in Parkinson's disease |
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