Abortive Infection of L Cells by Influenza B Virus: Defect in Bud Formation
Host-dependent restriction of influenza B virus replication in L cells was analysed in comparison with productive infection in MDCK or 1-5C-4 cells. The synthesis and intracellular distribution of virus-specific proteins and the production of cytoplasmic ribonucleoproteins in nonpermissive L cells w...
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| Veröffentlicht in: | MICROBIOLOGY and IMMUNOLOGY 1984, Vol.28(4), pp.427-437 |
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| container_issue | 4 |
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| container_title | MICROBIOLOGY and IMMUNOLOGY |
| container_volume | 28 |
| creator | Takeura, Shigeki Aoki, Hiizu Tsurumi, Tatsuya Nishiyama, Yukihiro Fujioka, Hisashi Yoshii, Saiji Maeno, Koichiro |
| description | Host-dependent restriction of influenza B virus replication in L cells was analysed in comparison with productive infection in MDCK or 1-5C-4 cells. The synthesis and intracellular distribution of virus-specific proteins and the production of cytoplasmic ribonucleoproteins in nonpermissive L cells were similar to those in permissive MDCK cells. However, an electron microscopic study of infected L cells showed neither extracellular virions nor budding virus particles on the cell surface, in contrast to MDCK cells which produced numerous virus particles. PAGE analysis of the plasma membrane isolated from the cells demonstrated no significant difference in the composition of viral polypeptides between permissive 1-5C-4 and nonpermissive L cells. It was noted that the abortiveness of influenza B virus infection in L cells may be due to a defect in host cell function involved in the initiation of virus budding. |
| doi_str_mv | 10.1111/j.1348-0421.1984.tb00694.x |
| format | Article |
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The synthesis and intracellular distribution of virus-specific proteins and the production of cytoplasmic ribonucleoproteins in nonpermissive L cells were similar to those in permissive MDCK cells. However, an electron microscopic study of infected L cells showed neither extracellular virions nor budding virus particles on the cell surface, in contrast to MDCK cells which produced numerous virus particles. PAGE analysis of the plasma membrane isolated from the cells demonstrated no significant difference in the composition of viral polypeptides between permissive 1-5C-4 and nonpermissive L cells. 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Psychology ; Influenza B virus ; L Cells (Cell Line) - metabolism ; L Cells (Cell Line) - microbiology ; Mice ; Microbiology ; Orthomyxoviridae - growth & development ; Orthomyxoviridae - metabolism ; Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains ; Ribonucleoproteins - biosynthesis ; Viral Proteins - biosynthesis ; Virology ; Virus Replication</subject><ispartof>MICROBIOLOGY and IMMUNOLOGY, 1984, Vol.28(4), pp.427-437</ispartof><rights>Center for Academic Publications Japan</rights><rights>owned by Center for Academic Publications Japan (Publisher)</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c5074-9e2241ab89c6c5ba1fe95d9a872298ae62ee045eacc561c2ed6af9f416484e723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8959319$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6748967$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takeura, Shigeki</creatorcontrib><creatorcontrib>Aoki, Hiizu</creatorcontrib><creatorcontrib>Tsurumi, Tatsuya</creatorcontrib><creatorcontrib>Nishiyama, Yukihiro</creatorcontrib><creatorcontrib>Fujioka, Hisashi</creatorcontrib><creatorcontrib>Yoshii, Saiji</creatorcontrib><creatorcontrib>Maeno, Koichiro</creatorcontrib><title>Abortive Infection of L Cells by Influenza B Virus: Defect in Bud Formation</title><title>MICROBIOLOGY and IMMUNOLOGY</title><addtitle>Microbiology and Immunology</addtitle><description>Host-dependent restriction of influenza B virus replication in L cells was analysed in comparison with productive infection in MDCK or 1-5C-4 cells. The synthesis and intracellular distribution of virus-specific proteins and the production of cytoplasmic ribonucleoproteins in nonpermissive L cells were similar to those in permissive MDCK cells. However, an electron microscopic study of infected L cells showed neither extracellular virions nor budding virus particles on the cell surface, in contrast to MDCK cells which produced numerous virus particles. PAGE analysis of the plasma membrane isolated from the cells demonstrated no significant difference in the composition of viral polypeptides between permissive 1-5C-4 and nonpermissive L cells. It was noted that the abortiveness of influenza B virus infection in L cells may be due to a defect in host cell function involved in the initiation of virus budding.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Budding</subject><subject>Cell Membrane - metabolism</subject><subject>Cytoplasm - metabolism</subject><subject>Dogs</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Influenza B virus</subject><subject>L Cells (Cell Line) - metabolism</subject><subject>L Cells (Cell Line) - microbiology</subject><subject>Mice</subject><subject>Microbiology</subject><subject>Orthomyxoviridae - growth & development</subject><subject>Orthomyxoviridae - metabolism</subject><subject>Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains</subject><subject>Ribonucleoproteins - biosynthesis</subject><subject>Viral Proteins - biosynthesis</subject><subject>Virology</subject><subject>Virus Replication</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkktv1DAUhSMEKkPhJyBZCCE2Cb6O40dXdIa2jJhCFzyWluO5gQx5lDiBGX49DhlFrEB4YVs-3z2-1nEUPQGaQBgvdgmkXMWUM0hAK570OaVC82R_J1rM0t1oQVOVxZmg9H70wPsdpUwyxU-iEyG50kIuojfnedv15Xck66ZA15dtQ9qCbMgKq8qT_DCeVwM2Py1Zko9lN_gz8gpHlJQNWQ5bctl2tR0LH0b3Clt5fHRcT6MPlxfvV6_jzbur9ep8E7uMSh5rZIyDzZV2wmW5hQJ1ttVWSca0sigYIuUZWucyAY7hVthCFxwEVxwlS0-jZ5Pvbdd-G9D3pi69C_3aBtvBGwUgNeMqgM__CgLXTABlSvzTE1IlMqohgGcT6LrW-w4Lc9uVte0OBqgZ0zE7M0ZgxgjMmI45pmP2ofjx8ZYhr3E7lx7jCPrTo269s1XR2caVfsaUznQKOmAvJ-xHWeHhPxow1-vr39tgcTFZ7HxvP-PsYcNncBWa2jbbErSUhinDp4kzOevui-0MNsEnnnxK3-P-D5uv4VGpzMynt1cGBMANkzdmmf4Ch8HRoQ</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>Takeura, Shigeki</creator><creator>Aoki, Hiizu</creator><creator>Tsurumi, Tatsuya</creator><creator>Nishiyama, Yukihiro</creator><creator>Fujioka, Hisashi</creator><creator>Yoshii, Saiji</creator><creator>Maeno, Koichiro</creator><general>Blackwell Publishing Ltd</general><general>Center For Academic Publications Japan</general><general>Center for Academic Publications Japan</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Abortive Infection of L Cells by Influenza B Virus: Defect in Bud Formation</title><author>Takeura, Shigeki ; Aoki, Hiizu ; Tsurumi, Tatsuya ; Nishiyama, Yukihiro ; Fujioka, Hisashi ; Yoshii, Saiji ; Maeno, Koichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5074-9e2241ab89c6c5ba1fe95d9a872298ae62ee045eacc561c2ed6af9f416484e723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Budding</topic><topic>Cell Membrane - metabolism</topic><topic>Cytoplasm - metabolism</topic><topic>Dogs</topic><topic>Fundamental and applied biological sciences. 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The synthesis and intracellular distribution of virus-specific proteins and the production of cytoplasmic ribonucleoproteins in nonpermissive L cells were similar to those in permissive MDCK cells. However, an electron microscopic study of infected L cells showed neither extracellular virions nor budding virus particles on the cell surface, in contrast to MDCK cells which produced numerous virus particles. PAGE analysis of the plasma membrane isolated from the cells demonstrated no significant difference in the composition of viral polypeptides between permissive 1-5C-4 and nonpermissive L cells. It was noted that the abortiveness of influenza B virus infection in L cells may be due to a defect in host cell function involved in the initiation of virus budding.</abstract><cop>Tokyo</cop><pub>Blackwell Publishing Ltd</pub><pmid>6748967</pmid><doi>10.1111/j.1348-0421.1984.tb00694.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | MICROBIOLOGY and IMMUNOLOGY, 1984, Vol.28(4), pp.427-437 |
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| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Budding Cell Membrane - metabolism Cytoplasm - metabolism Dogs Fundamental and applied biological sciences. Psychology Influenza B virus L Cells (Cell Line) - metabolism L Cells (Cell Line) - microbiology Mice Microbiology Orthomyxoviridae - growth & development Orthomyxoviridae - metabolism Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains Ribonucleoproteins - biosynthesis Viral Proteins - biosynthesis Virology Virus Replication |
| title | Abortive Infection of L Cells by Influenza B Virus: Defect in Bud Formation |
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