Creation of "Amyloid" Fibrils from Bence Jones Proteins in vitro

"Amyloid" fibrils have been created from some human Bence Jones proteins by proteolytic digestion under physiologic conditions. These fibrils with an antiparallel, β-pleated sheet conformation consist of only a portion of the variable region of the immunoglobulin light polypeptide chain an...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1971-11, Vol.174 (4010), p.712-714
Hauptverfasser:	Glenner, G. G., Ein, D., Eanes, E. D., Bladen, H. A., Terry, W., Page, D. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino acids Amyloid - analysis Amyloid - biosynthesis Amyloidosis Amyloids Bence Jones Protein - metabolism Cell lines Humans Hydrogen-Ion Concentration Immunoglobulins In Vitro Techniques Microscopy, Electron Muscle fibers Peptide Hydrolases Ploidies Solar fibrils Stem cells Temperature Tumor cell line X-Ray Diffraction
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