Mendelian and Uniparental Alterations in Erythromycin Binding by Plastid Ribosomes
Erythromycin binds specifically to the 52S subunit of the chloroplast ribosome of Chlamydomonas reinhardi. A number of erythromycin-resistant mutants whose ribosomes have lost their affinity for the antibiotic have been isolated, but the sedimentation properties of their ribosomes are indistinguisha...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1971-11, Vol.174 (4010), p.707-709 |
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| container_end_page | 709 |
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| container_issue | 4010 |
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| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 174 |
| creator | Mets, Laurens J. Bogorad, Lawrence |
| description | Erythromycin binds specifically to the 52S subunit of the chloroplast ribosome of Chlamydomonas reinhardi. A number of erythromycin-resistant mutants whose ribosomes have lost their affinity for the antibiotic have been isolated, but the sedimentation properties of their ribosomes are indistinguishable from those of the wild-type strain. These mutants represent at least three genetic loci. Two of them show Mendelian inheritance, and one of them is inherited in a uniparental manner. |
| doi_str_mv | 10.1126/science.174.4010.707 |
| format | Article |
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A number of erythromycin-resistant mutants whose ribosomes have lost their affinity for the antibiotic have been isolated, but the sedimentation properties of their ribosomes are indistinguishable from those of the wild-type strain. These mutants represent at least three genetic loci. Two of them show Mendelian inheritance, and one of them is inherited in a uniparental manner.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.174.4010.707</identifier><identifier>PMID: 5123420</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Binding Sites ; Carbon Isotopes ; Cell Fractionation ; Centrifugation, Density Gradient ; Chlorophyta - metabolism ; Chloroplasts ; Chloroplasts - metabolism ; Crosses, Genetic ; Drug Resistance, Microbial ; Erythromycin - metabolism ; Erythromycin - pharmacology ; Eukaryota - drug effects ; Genetic loci ; Genetic mutation ; Genetics, Microbial ; Muscle fibers ; Mutation ; Nucleic acids ; Plant cells ; Ribosomes ; Ribosomes - metabolism ; RNA</subject><ispartof>Science (American Association for the Advancement of Science), 1971-11, Vol.174 (4010), p.707-709</ispartof><rights>Copyright 1971 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c353t-1e54fc0696c1ae25bf366e1f8a72a938751f52119f79503e6ddf517c5723db8a3</citedby><cites>FETCH-LOGICAL-c353t-1e54fc0696c1ae25bf366e1f8a72a938751f52119f79503e6ddf517c5723db8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/1733760$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/1733760$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,778,782,801,2873,2874,27907,27908,58000,58233</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/5123420$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mets, Laurens J.</creatorcontrib><creatorcontrib>Bogorad, Lawrence</creatorcontrib><title>Mendelian and Uniparental Alterations in Erythromycin Binding by Plastid Ribosomes</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Erythromycin binds specifically to the 52S subunit of the chloroplast ribosome of Chlamydomonas reinhardi. A number of erythromycin-resistant mutants whose ribosomes have lost their affinity for the antibiotic have been isolated, but the sedimentation properties of their ribosomes are indistinguishable from those of the wild-type strain. These mutants represent at least three genetic loci. Two of them show Mendelian inheritance, and one of them is inherited in a uniparental manner.</description><subject>Binding Sites</subject><subject>Carbon Isotopes</subject><subject>Cell Fractionation</subject><subject>Centrifugation, Density Gradient</subject><subject>Chlorophyta - metabolism</subject><subject>Chloroplasts</subject><subject>Chloroplasts - metabolism</subject><subject>Crosses, Genetic</subject><subject>Drug Resistance, Microbial</subject><subject>Erythromycin - metabolism</subject><subject>Erythromycin - pharmacology</subject><subject>Eukaryota - drug effects</subject><subject>Genetic loci</subject><subject>Genetic mutation</subject><subject>Genetics, Microbial</subject><subject>Muscle fibers</subject><subject>Mutation</subject><subject>Nucleic acids</subject><subject>Plant cells</subject><subject>Ribosomes</subject><subject>Ribosomes - metabolism</subject><subject>RNA</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkMtOwzAQRS0EKqXwB0XKil2KJ47tZFlQeUhFoIquLceZgKvEKXa6yN-TqhGsRnfuY3EImQNdACTiPhiLzuACZLpI6fCVVJ6RKdCcx3lC2TmZUspEnFHJL8lVCDtKBy9nEzLhkLA0oVOyeUNXYm21i7Qro62ze-3RdbqOlnWHXne2dSGyLlr5vvv2bdObQTxYV1r3FRV99FHr0Nky2tiiDW2D4ZpcVLoOeDPeGdk-rT4fX-L1-_Pr43IdG8ZZFwPytDJU5MKAxoQXFRMCocq0THTOMsmh4glAXsmcU4aiLCsO0nCZsLLINJuRu9Pu3rc_BwydamwwWNfaYXsIKgOQGWRsCKanoPFtCB4rtfe20b5XQNURpRpRqgGlOqJUA8qhdjvuH4oGy7_SyG7w5yd_F7rW_29KxqSg7BcnFXrX</recordid><startdate>19711112</startdate><enddate>19711112</enddate><creator>Mets, Laurens J.</creator><creator>Bogorad, Lawrence</creator><general>American Association for the Advancement of Science</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19711112</creationdate><title>Mendelian and Uniparental Alterations in Erythromycin Binding by Plastid Ribosomes</title><author>Mets, Laurens J. ; Bogorad, Lawrence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c353t-1e54fc0696c1ae25bf366e1f8a72a938751f52119f79503e6ddf517c5723db8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>Binding Sites</topic><topic>Carbon Isotopes</topic><topic>Cell Fractionation</topic><topic>Centrifugation, Density Gradient</topic><topic>Chlorophyta - metabolism</topic><topic>Chloroplasts</topic><topic>Chloroplasts - metabolism</topic><topic>Crosses, Genetic</topic><topic>Drug Resistance, Microbial</topic><topic>Erythromycin - metabolism</topic><topic>Erythromycin - pharmacology</topic><topic>Eukaryota - drug effects</topic><topic>Genetic loci</topic><topic>Genetic mutation</topic><topic>Genetics, Microbial</topic><topic>Muscle fibers</topic><topic>Mutation</topic><topic>Nucleic acids</topic><topic>Plant cells</topic><topic>Ribosomes</topic><topic>Ribosomes - metabolism</topic><topic>RNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mets, Laurens J.</creatorcontrib><creatorcontrib>Bogorad, Lawrence</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mets, Laurens J.</au><au>Bogorad, Lawrence</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mendelian and Uniparental Alterations in Erythromycin Binding by Plastid Ribosomes</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1971-11-12</date><risdate>1971</risdate><volume>174</volume><issue>4010</issue><spage>707</spage><epage>709</epage><pages>707-709</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>Erythromycin binds specifically to the 52S subunit of the chloroplast ribosome of Chlamydomonas reinhardi. A number of erythromycin-resistant mutants whose ribosomes have lost their affinity for the antibiotic have been isolated, but the sedimentation properties of their ribosomes are indistinguishable from those of the wild-type strain. These mutants represent at least three genetic loci. Two of them show Mendelian inheritance, and one of them is inherited in a uniparental manner.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>5123420</pmid><doi>10.1126/science.174.4010.707</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1971-11, Vol.174 (4010), p.707-709 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81178183 |
| source | MEDLINE; American Association for the Advancement of Science; Jstor Complete Legacy |
| subjects | Binding Sites Carbon Isotopes Cell Fractionation Centrifugation, Density Gradient Chlorophyta - metabolism Chloroplasts Chloroplasts - metabolism Crosses, Genetic Drug Resistance, Microbial Erythromycin - metabolism Erythromycin - pharmacology Eukaryota - drug effects Genetic loci Genetic mutation Genetics, Microbial Muscle fibers Mutation Nucleic acids Plant cells Ribosomes Ribosomes - metabolism RNA |
| title | Mendelian and Uniparental Alterations in Erythromycin Binding by Plastid Ribosomes |
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