GASTRIC MORPHOLOGY, GASTRIN AND SOMATOSTATIN IN EXPERIMENTAL GASTRITIS IN MICE
The purpose of this study was to examine the morphological changes and endocrine profile (gastrin, somatostatin) in the gastric mucosa of mice with atrophic gastritis induced by neonatal thymectomy. The mice were killed on 2 months after thymectomy which was done on 3 days after birth in BALB/c (+/?...
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Veröffentlicht in: | Nippon Shokakibyo Gakkai Zasshi 1984, Vol.81(3), pp.817-824 |
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creator | SANO, Kohichi KANBARA, Akihiko OKAMOTO, Kazuma SHIMIZU, Satoru YAMAMOTO, Masahiro KOH, Hassei TAMARU, Takaji SUMII, Kohji KISHIMOTO, Shinya KAJIYAMA, Goro MIYOSHI, Akima |
description | The purpose of this study was to examine the morphological changes and endocrine profile (gastrin, somatostatin) in the gastric mucosa of mice with atrophic gastritis induced by neonatal thymectomy. The mice were killed on 2 months after thymectomy which was done on 3 days after birth in BALB/c (+/?) mice. Of the thymectomized mice, 27.4% had marked reduction of parietal and chief cells as well as inflammatory cell infiltration especially lymphocytes, plasma cells and eosinophilic cells, 64.1% of which had positive parietal cell antibody. Hypergastrinemia, antral G cell hyperplasia and increase of mucosal concentration of antral gastrin was observed in mice with this type of atrophic gastritis. On the other hand, mucosal concentration of somatostatin and the number of D cells in the body mucosa in mice with gastritis were decreased when compared to those in the control, but in the antrum the concentration and the number of D cells were almost the same as those in the control. |
doi_str_mv | 10.11405/nisshoshi1964.81.817 |
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The mice were killed on 2 months after thymectomy which was done on 3 days after birth in BALB/c (+/?) mice. Of the thymectomized mice, 27.4% had marked reduction of parietal and chief cells as well as inflammatory cell infiltration especially lymphocytes, plasma cells and eosinophilic cells, 64.1% of which had positive parietal cell antibody. Hypergastrinemia, antral G cell hyperplasia and increase of mucosal concentration of antral gastrin was observed in mice with this type of atrophic gastritis. On the other hand, mucosal concentration of somatostatin and the number of D cells in the body mucosa in mice with gastritis were decreased when compared to those in the control, but in the antrum the concentration and the number of D cells were almost the same as those in the control.</description><identifier>ISSN: 0446-6586</identifier><identifier>EISSN: 1349-7693</identifier><identifier>DOI: 10.11405/nisshoshi1964.81.817</identifier><identifier>PMID: 6146732</identifier><language>jpn</language><publisher>Japan: The Japanese Society of Gastroenterology</publisher><subject>Animals ; Gastric Mucosa - pathology ; Gastrins - blood ; Gastritis - blood ; Gastritis - pathology ; Mice ; Mice, Inbred BALB C ; Pyloric Antrum - pathology ; Somatostatin - blood ; Thymectomy</subject><ispartof>Nippon Shokakibyo Gakkai Zasshi, 1984, Vol.81(3), pp.817-824</ispartof><rights>The Japanese Society of Gastroenterology</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6146732$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SANO, Kohichi</creatorcontrib><creatorcontrib>KANBARA, Akihiko</creatorcontrib><creatorcontrib>OKAMOTO, Kazuma</creatorcontrib><creatorcontrib>SHIMIZU, Satoru</creatorcontrib><creatorcontrib>YAMAMOTO, Masahiro</creatorcontrib><creatorcontrib>KOH, Hassei</creatorcontrib><creatorcontrib>TAMARU, Takaji</creatorcontrib><creatorcontrib>SUMII, Kohji</creatorcontrib><creatorcontrib>KISHIMOTO, Shinya</creatorcontrib><creatorcontrib>KAJIYAMA, Goro</creatorcontrib><creatorcontrib>MIYOSHI, Akima</creatorcontrib><title>GASTRIC MORPHOLOGY, GASTRIN AND SOMATOSTATIN IN EXPERIMENTAL GASTRITIS IN MICE</title><title>Nippon Shokakibyo Gakkai Zasshi</title><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><description>The purpose of this study was to examine the morphological changes and endocrine profile (gastrin, somatostatin) in the gastric mucosa of mice with atrophic gastritis induced by neonatal thymectomy. The mice were killed on 2 months after thymectomy which was done on 3 days after birth in BALB/c (+/?) mice. Of the thymectomized mice, 27.4% had marked reduction of parietal and chief cells as well as inflammatory cell infiltration especially lymphocytes, plasma cells and eosinophilic cells, 64.1% of which had positive parietal cell antibody. Hypergastrinemia, antral G cell hyperplasia and increase of mucosal concentration of antral gastrin was observed in mice with this type of atrophic gastritis. On the other hand, mucosal concentration of somatostatin and the number of D cells in the body mucosa in mice with gastritis were decreased when compared to those in the control, but in the antrum the concentration and the number of D cells were almost the same as those in the control.</description><subject>Animals</subject><subject>Gastric Mucosa - pathology</subject><subject>Gastrins - blood</subject><subject>Gastritis - blood</subject><subject>Gastritis - pathology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Pyloric Antrum - pathology</subject><subject>Somatostatin - blood</subject><subject>Thymectomy</subject><issn>0446-6586</issn><issn>1349-7693</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkEtrg0AUhYfSkoY0PyHgqquaOs44j6VYmwhRQ7TQrmTUmcZgHnXMov--U2IDhcO9cL5zz-ICMIPOHELseM-HRuvtUW8byAmeM2hEb8AYIsxtSji6BWMHY2ITj5F7MNW6KR3H4R5nCI3AiEBMKHLHIFn4Wb6JAitON-tlukoXH0_WxUssP3mxsjT28zTL_dwYRuH7OtxEcZjk_moI5lH2S-IoCB_AnRKtltNhT8Dba5gHS9sUR4G_sneQ0d5GpK4ko5goXFIPuXXJFGMlwopg6krFpFAeZkrWjBIFmcsERZySEkkMOXfQBDxeek_d8essdV_sG13JthUHeTzrgkFIzYVrgrMheC73si5OXbMX3XcxPMDw6MJ3uhef8spF1zdVK4t_fza1Bfob9JqptqIr5AH9AJZSc6I</recordid><startdate>198403</startdate><enddate>198403</enddate><creator>SANO, Kohichi</creator><creator>KANBARA, Akihiko</creator><creator>OKAMOTO, Kazuma</creator><creator>SHIMIZU, Satoru</creator><creator>YAMAMOTO, Masahiro</creator><creator>KOH, Hassei</creator><creator>TAMARU, Takaji</creator><creator>SUMII, Kohji</creator><creator>KISHIMOTO, Shinya</creator><creator>KAJIYAMA, Goro</creator><creator>MIYOSHI, Akima</creator><general>The Japanese Society of Gastroenterology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198403</creationdate><title>GASTRIC MORPHOLOGY, GASTRIN AND SOMATOSTATIN IN EXPERIMENTAL GASTRITIS IN MICE</title><author>SANO, Kohichi ; KANBARA, Akihiko ; OKAMOTO, Kazuma ; SHIMIZU, Satoru ; YAMAMOTO, Masahiro ; KOH, Hassei ; TAMARU, Takaji ; SUMII, Kohji ; KISHIMOTO, Shinya ; KAJIYAMA, Goro ; MIYOSHI, Akima</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j187t-36dce8746f4b7532db8f88b34f6472ef8eaf548fed876f1828a73976b3e419903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>jpn</language><creationdate>1984</creationdate><topic>Animals</topic><topic>Gastric Mucosa - pathology</topic><topic>Gastrins - blood</topic><topic>Gastritis - blood</topic><topic>Gastritis - pathology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Pyloric Antrum - pathology</topic><topic>Somatostatin - blood</topic><topic>Thymectomy</topic><toplevel>online_resources</toplevel><creatorcontrib>SANO, Kohichi</creatorcontrib><creatorcontrib>KANBARA, Akihiko</creatorcontrib><creatorcontrib>OKAMOTO, Kazuma</creatorcontrib><creatorcontrib>SHIMIZU, Satoru</creatorcontrib><creatorcontrib>YAMAMOTO, Masahiro</creatorcontrib><creatorcontrib>KOH, Hassei</creatorcontrib><creatorcontrib>TAMARU, Takaji</creatorcontrib><creatorcontrib>SUMII, Kohji</creatorcontrib><creatorcontrib>KISHIMOTO, Shinya</creatorcontrib><creatorcontrib>KAJIYAMA, Goro</creatorcontrib><creatorcontrib>MIYOSHI, Akima</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANO, Kohichi</au><au>KANBARA, Akihiko</au><au>OKAMOTO, Kazuma</au><au>SHIMIZU, Satoru</au><au>YAMAMOTO, Masahiro</au><au>KOH, Hassei</au><au>TAMARU, Takaji</au><au>SUMII, Kohji</au><au>KISHIMOTO, Shinya</au><au>KAJIYAMA, Goro</au><au>MIYOSHI, Akima</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GASTRIC MORPHOLOGY, GASTRIN AND SOMATOSTATIN IN EXPERIMENTAL GASTRITIS IN MICE</atitle><jtitle>Nippon Shokakibyo Gakkai Zasshi</jtitle><addtitle>Nippon Shokakibyo Gakkai Zasshi</addtitle><date>1984-03</date><risdate>1984</risdate><volume>81</volume><issue>3</issue><spage>817</spage><epage>824</epage><pages>817-824</pages><issn>0446-6586</issn><eissn>1349-7693</eissn><abstract>The purpose of this study was to examine the morphological changes and endocrine profile (gastrin, somatostatin) in the gastric mucosa of mice with atrophic gastritis induced by neonatal thymectomy. 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subjects | Animals Gastric Mucosa - pathology Gastrins - blood Gastritis - blood Gastritis - pathology Mice Mice, Inbred BALB C Pyloric Antrum - pathology Somatostatin - blood Thymectomy |
title | GASTRIC MORPHOLOGY, GASTRIN AND SOMATOSTATIN IN EXPERIMENTAL GASTRITIS IN MICE |
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