Heparin-mediated inactivation and transformation of mammary cytoplasmic glucocorticoid receptor

Glucocorticoid receptor of lactating mouse mammary gland cytosol was exposed to heparin when the receptor was either steroid-free or steroid-bound. Heparin caused a dose-dependent and time-dependent loss of steroid binding activity (inactivation) of the steroid-free receptor; this heparin-induced in...

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Veröffentlicht in:	Journal of steroid biochemistry 1984-06, Vol.20 (6), p.1211-1220
Hauptverfasser:	McBlain, W.A., Shyamala, G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell receptors Cell structures and functions Cytosol - metabolism Dexamethasone - metabolism Female Fundamental and applied biological sciences. Psychology Heparin - pharmacology Kinetics Lactation Mammary Glands, Animal - metabolism Mice Mice, Inbred BALB C Molecular and cellular biology Pregnancy Receptors, Glucocorticoid - drug effects Receptors, Glucocorticoid - isolation & purification Receptors, Glucocorticoid - metabolism Receptors, Steroid - metabolism
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