Myocardial Perfusion and Left Ventricular Performance during Exercise-Induced ST-Segment Depression in Apparently Healthy Subjects
Ischemic-like ST-segment depression seen during exercise in apparently healthy subjects has previously been noted, but the cause of this change is unknown. The aim of this study was to investigate the pathophysiology of this electrocardiographic change. Ten healthy subjects who developed an electroc...
Gespeichert in:
| Veröffentlicht in: | Japanese Heart Journal 1984, Vol.25(2), pp.155-166 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 166 |
|---|---|
| container_issue | 2 |
| container_start_page | 155 |
| container_title | Japanese Heart Journal |
| container_volume | 25 |
| creator | ANDO, Joji YASUDA, Hisakazu MIYAMOTO, Atsushi KOBAYASHI, Takeshi NISHIJIMA, Hirotaka KANAMORI, Katsushi MATSUMURA, Naoya |
| description | Ischemic-like ST-segment depression seen during exercise in apparently healthy subjects has previously been noted, but the cause of this change is unknown. The aim of this study was to investigate the pathophysiology of this electrocardiographic change. Ten healthy subjects who developed an electrocardiographic "ischemic" pattern of ST change during treadmill exercise testing were studied. All subjects underwent both thallium-201 myocardial perfusion imaging and radionuclide angiocardiography at rest and during exercise at a time when abnormal ST changes appeared, and demonstrated a normal homogeneous pattern of thallium-201 distribution on both rest and exercise images. Overall, left ventricular ejection fraction rose from 0.60±0.06 (mean±SD) at rest to 0.65±0.07 with exercise. None of the subjects had regional wall motion abnormalities at rest or during exercise. These results are different from the findings observed in patients with coronary heart disease and angina pectoris in whom regional abnormalities in both perfusion and left ventricular performance have been noted during exercise. Therefore it would seem that myocardial ischemia is not likely to be a tenable explanation for the electrocardiographic "ischemic" changes in these apparently healthy subjects. |
| doi_str_mv | 10.1536/ihj.25.155 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_81176847</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>81176847</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-eaad6773c927c5a62b88ce477c2101ded74d56ad422ad451318a635fe0591e5c3</originalsourceid><addsrcrecordid>eNo9kM2LFDEQxYMo67h68S7kIB6EXvPRSaePy7i6CyMKs4q3piapnsmQ_jDpBufqX25mZ5hLpaj3y3vwCHnL2Q1XUn_yu_2NUHlXz8iCy9IUupK_n5MFY4IXpdHmJXmV0p4xroWRV-RKC6mkEQvy79thsBCdh0B_YGzn5IeeQu_oCtuJ_sJ-it7OAeKTPMQOeovUzdH3W3r3F6P1CYuH3s0WHV0_FmvcdvkX_YxjxPRk53t6O44Q8zkc6D1CmHYHup43e7RTek1etBASvjm_1-Tnl7vH5X2x-v71YXm7KqyScioQwOmqkrYWlVWgxcYYi2VVWcEZd-iq0ikNrhQiD8UlN6ClapGpmqOy8pp8OPmOcfgzY5qazieLIUCPw5waw3mlTVll8OMJtHFIKWLbjNF3EA8NZ82x8CYX3giVd5Xhd2fXedOhu6DnhrP-_qxDshDamPvz6YLVumQ1O2LLE7ZPE2zxokOcvA14TOS1ZsdUcRo5_KLaHcQGe_kfeR6iZw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>81176847</pqid></control><display><type>article</type><title>Myocardial Perfusion and Left Ventricular Performance during Exercise-Induced ST-Segment Depression in Apparently Healthy Subjects</title><source>J-STAGE Free</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>ANDO, Joji ; YASUDA, Hisakazu ; MIYAMOTO, Atsushi ; KOBAYASHI, Takeshi ; NISHIJIMA, Hirotaka ; KANAMORI, Katsushi ; MATSUMURA, Naoya</creator><creatorcontrib>ANDO, Joji ; YASUDA, Hisakazu ; MIYAMOTO, Atsushi ; KOBAYASHI, Takeshi ; NISHIJIMA, Hirotaka ; KANAMORI, Katsushi ; MATSUMURA, Naoya</creatorcontrib><description>Ischemic-like ST-segment depression seen during exercise in apparently healthy subjects has previously been noted, but the cause of this change is unknown. The aim of this study was to investigate the pathophysiology of this electrocardiographic change. Ten healthy subjects who developed an electrocardiographic "ischemic" pattern of ST change during treadmill exercise testing were studied. All subjects underwent both thallium-201 myocardial perfusion imaging and radionuclide angiocardiography at rest and during exercise at a time when abnormal ST changes appeared, and demonstrated a normal homogeneous pattern of thallium-201 distribution on both rest and exercise images. Overall, left ventricular ejection fraction rose from 0.60±0.06 (mean±SD) at rest to 0.65±0.07 with exercise. None of the subjects had regional wall motion abnormalities at rest or during exercise. These results are different from the findings observed in patients with coronary heart disease and angina pectoris in whom regional abnormalities in both perfusion and left ventricular performance have been noted during exercise. Therefore it would seem that myocardial ischemia is not likely to be a tenable explanation for the electrocardiographic "ischemic" changes in these apparently healthy subjects.</description><identifier>ISSN: 0021-4868</identifier><identifier>EISSN: 1348-673X</identifier><identifier>DOI: 10.1536/ihj.25.155</identifier><identifier>PMID: 6235382</identifier><identifier>CODEN: JHEJAR</identifier><language>eng</language><publisher>Tokyo: International Heart Journal Association</publisher><subject>Adult ; Angina Pectoris - physiopathology ; Asymptomatic ST changes ; Biological and medical sciences ; Coronary Circulation ; Electrocardiography ; Electrocardiography. Vectocardiography ; Electrodiagnosis. Electric activity recording ; Exercise Test ; Exercise testing ; False positive ; Female ; Heart - diagnostic imaging ; Heart - physiopathology ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Myocardial ischemia ; Painless ST depression ; Radioisotopes ; Radionuclide Imaging ; Screening test ; Serum Albumin ; Stroke Volume ; Technetium ; Technetium Tc 99m Aggregated Albumin ; Thallium</subject><ispartof>Japanese Heart Journal, 1984, Vol.25(2), pp.155-166</ispartof><rights>by International Heart Journal Association</rights><rights>1984 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9640902$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6235382$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ANDO, Joji</creatorcontrib><creatorcontrib>YASUDA, Hisakazu</creatorcontrib><creatorcontrib>MIYAMOTO, Atsushi</creatorcontrib><creatorcontrib>KOBAYASHI, Takeshi</creatorcontrib><creatorcontrib>NISHIJIMA, Hirotaka</creatorcontrib><creatorcontrib>KANAMORI, Katsushi</creatorcontrib><creatorcontrib>MATSUMURA, Naoya</creatorcontrib><title>Myocardial Perfusion and Left Ventricular Performance during Exercise-Induced ST-Segment Depression in Apparently Healthy Subjects</title><title>Japanese Heart Journal</title><addtitle>Jpn Heart J</addtitle><description>Ischemic-like ST-segment depression seen during exercise in apparently healthy subjects has previously been noted, but the cause of this change is unknown. The aim of this study was to investigate the pathophysiology of this electrocardiographic change. Ten healthy subjects who developed an electrocardiographic "ischemic" pattern of ST change during treadmill exercise testing were studied. All subjects underwent both thallium-201 myocardial perfusion imaging and radionuclide angiocardiography at rest and during exercise at a time when abnormal ST changes appeared, and demonstrated a normal homogeneous pattern of thallium-201 distribution on both rest and exercise images. Overall, left ventricular ejection fraction rose from 0.60±0.06 (mean±SD) at rest to 0.65±0.07 with exercise. None of the subjects had regional wall motion abnormalities at rest or during exercise. These results are different from the findings observed in patients with coronary heart disease and angina pectoris in whom regional abnormalities in both perfusion and left ventricular performance have been noted during exercise. Therefore it would seem that myocardial ischemia is not likely to be a tenable explanation for the electrocardiographic "ischemic" changes in these apparently healthy subjects.</description><subject>Adult</subject><subject>Angina Pectoris - physiopathology</subject><subject>Asymptomatic ST changes</subject><subject>Biological and medical sciences</subject><subject>Coronary Circulation</subject><subject>Electrocardiography</subject><subject>Electrocardiography. Vectocardiography</subject><subject>Electrodiagnosis. Electric activity recording</subject><subject>Exercise Test</subject><subject>Exercise testing</subject><subject>False positive</subject><subject>Female</subject><subject>Heart - diagnostic imaging</subject><subject>Heart - physiopathology</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial ischemia</subject><subject>Painless ST depression</subject><subject>Radioisotopes</subject><subject>Radionuclide Imaging</subject><subject>Screening test</subject><subject>Serum Albumin</subject><subject>Stroke Volume</subject><subject>Technetium</subject><subject>Technetium Tc 99m Aggregated Albumin</subject><subject>Thallium</subject><issn>0021-4868</issn><issn>1348-673X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM2LFDEQxYMo67h68S7kIB6EXvPRSaePy7i6CyMKs4q3piapnsmQ_jDpBufqX25mZ5hLpaj3y3vwCHnL2Q1XUn_yu_2NUHlXz8iCy9IUupK_n5MFY4IXpdHmJXmV0p4xroWRV-RKC6mkEQvy79thsBCdh0B_YGzn5IeeQu_oCtuJ_sJ-it7OAeKTPMQOeovUzdH3W3r3F6P1CYuH3s0WHV0_FmvcdvkX_YxjxPRk53t6O44Q8zkc6D1CmHYHup43e7RTek1etBASvjm_1-Tnl7vH5X2x-v71YXm7KqyScioQwOmqkrYWlVWgxcYYi2VVWcEZd-iq0ikNrhQiD8UlN6ClapGpmqOy8pp8OPmOcfgzY5qazieLIUCPw5waw3mlTVll8OMJtHFIKWLbjNF3EA8NZ82x8CYX3giVd5Xhd2fXedOhu6DnhrP-_qxDshDamPvz6YLVumQ1O2LLE7ZPE2zxokOcvA14TOS1ZsdUcRo5_KLaHcQGe_kfeR6iZw</recordid><startdate>19840101</startdate><enddate>19840101</enddate><creator>ANDO, Joji</creator><creator>YASUDA, Hisakazu</creator><creator>MIYAMOTO, Atsushi</creator><creator>KOBAYASHI, Takeshi</creator><creator>NISHIJIMA, Hirotaka</creator><creator>KANAMORI, Katsushi</creator><creator>MATSUMURA, Naoya</creator><general>International Heart Journal Association</general><general>Japanese Heart Journal Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840101</creationdate><title>Myocardial Perfusion and Left Ventricular Performance during Exercise-Induced ST-Segment Depression in Apparently Healthy Subjects</title><author>ANDO, Joji ; YASUDA, Hisakazu ; MIYAMOTO, Atsushi ; KOBAYASHI, Takeshi ; NISHIJIMA, Hirotaka ; KANAMORI, Katsushi ; MATSUMURA, Naoya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-eaad6773c927c5a62b88ce477c2101ded74d56ad422ad451318a635fe0591e5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adult</topic><topic>Angina Pectoris - physiopathology</topic><topic>Asymptomatic ST changes</topic><topic>Biological and medical sciences</topic><topic>Coronary Circulation</topic><topic>Electrocardiography</topic><topic>Electrocardiography. Vectocardiography</topic><topic>Electrodiagnosis. Electric activity recording</topic><topic>Exercise Test</topic><topic>Exercise testing</topic><topic>False positive</topic><topic>Female</topic><topic>Heart - diagnostic imaging</topic><topic>Heart - physiopathology</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial ischemia</topic><topic>Painless ST depression</topic><topic>Radioisotopes</topic><topic>Radionuclide Imaging</topic><topic>Screening test</topic><topic>Serum Albumin</topic><topic>Stroke Volume</topic><topic>Technetium</topic><topic>Technetium Tc 99m Aggregated Albumin</topic><topic>Thallium</topic><toplevel>online_resources</toplevel><creatorcontrib>ANDO, Joji</creatorcontrib><creatorcontrib>YASUDA, Hisakazu</creatorcontrib><creatorcontrib>MIYAMOTO, Atsushi</creatorcontrib><creatorcontrib>KOBAYASHI, Takeshi</creatorcontrib><creatorcontrib>NISHIJIMA, Hirotaka</creatorcontrib><creatorcontrib>KANAMORI, Katsushi</creatorcontrib><creatorcontrib>MATSUMURA, Naoya</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Japanese Heart Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>ANDO, Joji</au><au>YASUDA, Hisakazu</au><au>MIYAMOTO, Atsushi</au><au>KOBAYASHI, Takeshi</au><au>NISHIJIMA, Hirotaka</au><au>KANAMORI, Katsushi</au><au>MATSUMURA, Naoya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Myocardial Perfusion and Left Ventricular Performance during Exercise-Induced ST-Segment Depression in Apparently Healthy Subjects</atitle><jtitle>Japanese Heart Journal</jtitle><addtitle>Jpn Heart J</addtitle><date>1984-01-01</date><risdate>1984</risdate><volume>25</volume><issue>2</issue><spage>155</spage><epage>166</epage><pages>155-166</pages><issn>0021-4868</issn><eissn>1348-673X</eissn><coden>JHEJAR</coden><abstract>Ischemic-like ST-segment depression seen during exercise in apparently healthy subjects has previously been noted, but the cause of this change is unknown. The aim of this study was to investigate the pathophysiology of this electrocardiographic change. Ten healthy subjects who developed an electrocardiographic "ischemic" pattern of ST change during treadmill exercise testing were studied. All subjects underwent both thallium-201 myocardial perfusion imaging and radionuclide angiocardiography at rest and during exercise at a time when abnormal ST changes appeared, and demonstrated a normal homogeneous pattern of thallium-201 distribution on both rest and exercise images. Overall, left ventricular ejection fraction rose from 0.60±0.06 (mean±SD) at rest to 0.65±0.07 with exercise. None of the subjects had regional wall motion abnormalities at rest or during exercise. These results are different from the findings observed in patients with coronary heart disease and angina pectoris in whom regional abnormalities in both perfusion and left ventricular performance have been noted during exercise. Therefore it would seem that myocardial ischemia is not likely to be a tenable explanation for the electrocardiographic "ischemic" changes in these apparently healthy subjects.</abstract><cop>Tokyo</cop><pub>International Heart Journal Association</pub><pmid>6235382</pmid><doi>10.1536/ihj.25.155</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-4868 |
| ispartof | Japanese Heart Journal, 1984, Vol.25(2), pp.155-166 |
| issn | 0021-4868 1348-673X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_81176847 |
| source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Angina Pectoris - physiopathology Asymptomatic ST changes Biological and medical sciences Coronary Circulation Electrocardiography Electrocardiography. Vectocardiography Electrodiagnosis. Electric activity recording Exercise Test Exercise testing False positive Female Heart - diagnostic imaging Heart - physiopathology Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Myocardial ischemia Painless ST depression Radioisotopes Radionuclide Imaging Screening test Serum Albumin Stroke Volume Technetium Technetium Tc 99m Aggregated Albumin Thallium |
| title | Myocardial Perfusion and Left Ventricular Performance during Exercise-Induced ST-Segment Depression in Apparently Healthy Subjects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-06T18%3A37%3A27IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Myocardial%20Perfusion%20and%20Left%20Ventricular%20Performance%20during%20Exercise-Induced%20ST-Segment%20Depression%20in%20Apparently%20Healthy%20Subjects&rft.jtitle=Japanese%20Heart%20Journal&rft.au=ANDO,%20Joji&rft.date=1984-01-01&rft.volume=25&rft.issue=2&rft.spage=155&rft.epage=166&rft.pages=155-166&rft.issn=0021-4868&rft.eissn=1348-673X&rft.coden=JHEJAR&rft_id=info:doi/10.1536/ihj.25.155&rft_dat=%3Cproquest_cross%3E81176847%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=81176847&rft_id=info:pmid/6235382&rfr_iscdi=true |