Immunoenhancing effect of flavonoid compounds on lymphocyte proliferation and immunoglobulin synthesis
Flavonoid compounds are lipophilic agents which can interact with membrane lipids and may affect responsiveness of immune cells. We therefore studied whether cianidanol ((+)-catechin), the O-methyl- derivative (+)-3-methoxy-5,7,3′,4′-tetrahydroxyflavan and palmitoyl- derivative (+)-3-palmitoyl-ubiqu...
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| Veröffentlicht in: | International journal of immunopharmacology 1984, Vol.6 (3), p.205-215 |
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| container_title | International journal of immunopharmacology |
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| creator | Brattig, N.W. Diao, G.-J. Berg, P.A. |
| description | Flavonoid compounds are lipophilic agents which can interact with membrane lipids and may affect responsiveness of immune cells. We therefore studied whether cianidanol ((+)-catechin), the O-methyl-
derivative (+)-3-methoxy-5,7,3′,4′-tetrahydroxyflavan and palmitoyl-
derivative (+)-3-palmitoyl-ubiquinone 5,7,3′,4′-tetrahydroxyflavan influence T and B cell functions. In addition, immunomolatory property of ubiquinone 50 was also investigated. As controls were used cyclosporin A and and inosine which are known to inhibit or enhance immune responses, respectively.
The
in vitro spontaneous, antigen and mitogen induced proliferation as well as immunoglobulin synthesis of peripheral blood mononuclear cells from healthy individuals was determined in the presence of different concentrations of the agents. All flavonoid compounds and ubiquinone 50 significantly increased (
p |
| doi_str_mv | 10.1016/0192-0561(84)90018-3 |
| format | Article |
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derivative (+)-3-methoxy-5,7,3′,4′-tetrahydroxyflavan and palmitoyl-
derivative (+)-3-palmitoyl-ubiquinone 5,7,3′,4′-tetrahydroxyflavan influence T and B cell functions. In addition, immunomolatory property of ubiquinone 50 was also investigated. As controls were used cyclosporin A and and inosine which are known to inhibit or enhance immune responses, respectively.
The
in vitro spontaneous, antigen and mitogen induced proliferation as well as immunoglobulin synthesis of peripheral blood mononuclear cells from healthy individuals was determined in the presence of different concentrations of the agents. All flavonoid compounds and ubiquinone 50 significantly increased (
p<5 − <0.01) the spontaneous lymphocyte transformation but hardly affected antigen, alloantigen and mitogen induced proliferative response. Only cianidanol and O-methyl-derivative enhanced significantly (
p<0.05 − <0.01) spontaneous, pokeweedmitogen and Staphylococcus aureus Cowan I induced immunoglobulin synthesis while the palmitoyl-derivative and ubiquinone 50 had only minor influence on B cell function. In contrast, Staphylococcus aureus induced immunoglubulin production was neither increased by inosine nor suppressed by cyclosporin A.
These studies show that especially cianidanol and the O-methyl-derivative can exert an immunoenhancing effect on T and B cell functions.</description><identifier>ISSN: 0192-0561</identifier><identifier>EISSN: 1879-3495</identifier><identifier>DOI: 10.1016/0192-0561(84)90018-3</identifier><identifier>PMID: 6746173</identifier><identifier>CODEN: IJIMDS</identifier><language>eng</language><publisher>Oxford: Elsevier Science</publisher><subject>Adjuvants, Immunologic ; Adult ; Antigens - pharmacology ; Biological and medical sciences ; Cell Division - drug effects ; Female ; Flavonoids - pharmacology ; Humans ; Immunoglobulin G - biosynthesis ; Immunoglobulins - biosynthesis ; Immunomodulators ; In Vitro Techniques ; Lymphocyte Activation - drug effects ; Lymphocytes - drug effects ; Lymphocytes - metabolism ; Male ; Medical sciences ; Middle Aged ; Mitogens - pharmacology ; Pharmacology. Drug treatments</subject><ispartof>International journal of immunopharmacology, 1984, Vol.6 (3), p.205-215</ispartof><rights>1984</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-9a4a180d6a7ba95b60efe5c48a61666880f3217f32324ed3cc60bb263bce95b3</citedby><cites>FETCH-LOGICAL-c483t-9a4a180d6a7ba95b60efe5c48a61666880f3217f32324ed3cc60bb263bce95b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4009,27902,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9011612$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6746173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Brattig, N.W.</creatorcontrib><creatorcontrib>Diao, G.-J.</creatorcontrib><creatorcontrib>Berg, P.A.</creatorcontrib><title>Immunoenhancing effect of flavonoid compounds on lymphocyte proliferation and immunoglobulin synthesis</title><title>International journal of immunopharmacology</title><addtitle>Int J Immunopharmacol</addtitle><description>Flavonoid compounds are lipophilic agents which can interact with membrane lipids and may affect responsiveness of immune cells. We therefore studied whether cianidanol ((+)-catechin), the O-methyl-
derivative (+)-3-methoxy-5,7,3′,4′-tetrahydroxyflavan and palmitoyl-
derivative (+)-3-palmitoyl-ubiquinone 5,7,3′,4′-tetrahydroxyflavan influence T and B cell functions. In addition, immunomolatory property of ubiquinone 50 was also investigated. As controls were used cyclosporin A and and inosine which are known to inhibit or enhance immune responses, respectively.
The
in vitro spontaneous, antigen and mitogen induced proliferation as well as immunoglobulin synthesis of peripheral blood mononuclear cells from healthy individuals was determined in the presence of different concentrations of the agents. All flavonoid compounds and ubiquinone 50 significantly increased (
p<5 − <0.01) the spontaneous lymphocyte transformation but hardly affected antigen, alloantigen and mitogen induced proliferative response. Only cianidanol and O-methyl-derivative enhanced significantly (
p<0.05 − <0.01) spontaneous, pokeweedmitogen and Staphylococcus aureus Cowan I induced immunoglobulin synthesis while the palmitoyl-derivative and ubiquinone 50 had only minor influence on B cell function. In contrast, Staphylococcus aureus induced immunoglubulin production was neither increased by inosine nor suppressed by cyclosporin A.
These studies show that especially cianidanol and the O-methyl-derivative can exert an immunoenhancing effect on T and B cell functions.</description><subject>Adjuvants, Immunologic</subject><subject>Adult</subject><subject>Antigens - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Division - drug effects</subject><subject>Female</subject><subject>Flavonoids - pharmacology</subject><subject>Humans</subject><subject>Immunoglobulin G - biosynthesis</subject><subject>Immunoglobulins - biosynthesis</subject><subject>Immunomodulators</subject><subject>In Vitro Techniques</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocytes - drug effects</subject><subject>Lymphocytes - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mitogens - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><issn>0192-0561</issn><issn>1879-3495</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFv1DAQhS0EKtvCPwDJB4TgEPDEjuNcKqGKQqVKXHq3HGfcNXLsxU4q7b_H213tES4zh_fN0-g9Qt4B-wIM5FcGQ9uwTsInJT4PjIFq-AuyAdUPDRdD95JszshrclnKb8ZYB7K9IBeyFxJ6viHubp7XmDBuTbQ-PlJ0Du1Ck6MumKcUk5-oTfMurXEqNEUa9vNum-x-QbrLKXiH2Sy-CiZO1D-7PYY0rsFHWvZx2WLx5Q155Uwo-Pa0r8jD7feHm5_N_a8fdzff7hsrFF-awQgDik3S9KMZulEydNhVzUiQUirFHG-hr4O3AidurWTj2Eo-Wqw4vyIfj7b1sz8rlkXPvlgMwURMa9EKoAdg4r8g8EH0Xd9VUBxBm1MpGZ3eZT-bvNfA9KEGfchYHzLWSujnGjSvZ-9P_us443Q-OuVe9Q8n3RRrgsuH9MsZGxiAhLZi10cMa2ZPHrMu1mO0OPlcW9JT8v_-4y9V6qWd</recordid><startdate>1984</startdate><enddate>1984</enddate><creator>Brattig, N.W.</creator><creator>Diao, G.-J.</creator><creator>Berg, P.A.</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>1984</creationdate><title>Immunoenhancing effect of flavonoid compounds on lymphocyte proliferation and immunoglobulin synthesis</title><author>Brattig, N.W. ; Diao, G.-J. ; Berg, P.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-9a4a180d6a7ba95b60efe5c48a61666880f3217f32324ed3cc60bb263bce95b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Adjuvants, Immunologic</topic><topic>Adult</topic><topic>Antigens - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Division - drug effects</topic><topic>Female</topic><topic>Flavonoids - pharmacology</topic><topic>Humans</topic><topic>Immunoglobulin G - biosynthesis</topic><topic>Immunoglobulins - biosynthesis</topic><topic>Immunomodulators</topic><topic>In Vitro Techniques</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocytes - drug effects</topic><topic>Lymphocytes - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mitogens - pharmacology</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Brattig, N.W.</creatorcontrib><creatorcontrib>Diao, G.-J.</creatorcontrib><creatorcontrib>Berg, P.A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of immunopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Brattig, N.W.</au><au>Diao, G.-J.</au><au>Berg, P.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoenhancing effect of flavonoid compounds on lymphocyte proliferation and immunoglobulin synthesis</atitle><jtitle>International journal of immunopharmacology</jtitle><addtitle>Int J Immunopharmacol</addtitle><date>1984</date><risdate>1984</risdate><volume>6</volume><issue>3</issue><spage>205</spage><epage>215</epage><pages>205-215</pages><issn>0192-0561</issn><eissn>1879-3495</eissn><coden>IJIMDS</coden><abstract>Flavonoid compounds are lipophilic agents which can interact with membrane lipids and may affect responsiveness of immune cells. We therefore studied whether cianidanol ((+)-catechin), the O-methyl-
derivative (+)-3-methoxy-5,7,3′,4′-tetrahydroxyflavan and palmitoyl-
derivative (+)-3-palmitoyl-ubiquinone 5,7,3′,4′-tetrahydroxyflavan influence T and B cell functions. In addition, immunomolatory property of ubiquinone 50 was also investigated. As controls were used cyclosporin A and and inosine which are known to inhibit or enhance immune responses, respectively.
The
in vitro spontaneous, antigen and mitogen induced proliferation as well as immunoglobulin synthesis of peripheral blood mononuclear cells from healthy individuals was determined in the presence of different concentrations of the agents. All flavonoid compounds and ubiquinone 50 significantly increased (
p<5 − <0.01) the spontaneous lymphocyte transformation but hardly affected antigen, alloantigen and mitogen induced proliferative response. Only cianidanol and O-methyl-derivative enhanced significantly (
p<0.05 − <0.01) spontaneous, pokeweedmitogen and Staphylococcus aureus Cowan I induced immunoglobulin synthesis while the palmitoyl-derivative and ubiquinone 50 had only minor influence on B cell function. In contrast, Staphylococcus aureus induced immunoglubulin production was neither increased by inosine nor suppressed by cyclosporin A.
These studies show that especially cianidanol and the O-methyl-derivative can exert an immunoenhancing effect on T and B cell functions.</abstract><cop>Oxford</cop><pub>Elsevier Science</pub><pmid>6746173</pmid><doi>10.1016/0192-0561(84)90018-3</doi><tpages>11</tpages></addata></record> |
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| ispartof | International journal of immunopharmacology, 1984, Vol.6 (3), p.205-215 |
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| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adjuvants, Immunologic Adult Antigens - pharmacology Biological and medical sciences Cell Division - drug effects Female Flavonoids - pharmacology Humans Immunoglobulin G - biosynthesis Immunoglobulins - biosynthesis Immunomodulators In Vitro Techniques Lymphocyte Activation - drug effects Lymphocytes - drug effects Lymphocytes - metabolism Male Medical sciences Middle Aged Mitogens - pharmacology Pharmacology. Drug treatments |
| title | Immunoenhancing effect of flavonoid compounds on lymphocyte proliferation and immunoglobulin synthesis |
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