Kainic acid-induced denervation supersensitivity of nicotinic, cholinergic receptors in ganglion cells of the rat retina

The rat retina contains both nicotinic and muscarinic cholinergic receptor sites as demonstrated by specific, high affinity binding of the nicotinic ligand, [ 3H]-α-bungarotoxin, and the muscarinic ligand, [ 3H]-quinuclidinyl benzylate. Seven days after an intraocular injection of 5 nmol of kainic a...

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Veröffentlicht in:	Experimental eye research 1984-01, Vol.38 (5), p.449-461
Hauptverfasser:	Redburn, D.A., Donoso, J.A., Mitchell, C.K., Gomez-Ramos, P., Samson, F.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholine - pharmacology amacrine cell Animals Biological and medical sciences Bungarotoxins - metabolism Eye and associated structures. Visual pathways and centers. Vision Fundamental and applied biological sciences. Psychology ganglion cell ganglion cells kainic acid Kainic Acid - pharmacology muscarinic nicotinic Pyrrolidines - pharmacology Quinuclidinyl Benzilate - metabolism Rats Rats, Inbred Strains receptor Receptors, Cholinergic - drug effects Receptors, Cholinergic - metabolism Receptors, Nicotinic - drug effects Receptors, Nicotinic - metabolism retina Retina - metabolism Retinal Ganglion Cells - drug effects Retinal Ganglion Cells - metabolism Vertebrates: nervous system and sense organs
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