A monoclonal antibody, CSTO-1, against a stomach adenocarcinoma-associated antigen
A monoclonal antibody, CSTO-1, has been produced against a stomach adenocarcinoma-associated antigen. The antibody is cytotoxic to stomach, colon, and lung adenocarcinoma lines but is completely noncytotoxic to normal blood elements and leukemic cell lines. The monoclonal antibody reacts with tumor...
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| Veröffentlicht in: | Cancer research (Chicago, Ill.) Ill.), 1984-09, Vol.44 (9), p.3952-3956 |
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| container_title | Cancer research (Chicago, Ill.) |
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| creator | TOGASHI, H TERASAKI, P. I CHIA, D KUKES, G MUGISHIMA, H KASAI, K SUYAMA, N FUKUSHIMA, K HIROTA, M |
| description | A monoclonal antibody, CSTO-1, has been produced against a stomach adenocarcinoma-associated antigen. The antibody is cytotoxic to stomach, colon, and lung adenocarcinoma lines but is completely noncytotoxic to normal blood elements and leukemic cell lines. The monoclonal antibody reacts with tumor cell membranes in enzyme-linked immunosorbent assay and is negative to cell membranes from various normal tissues. By immunoperoxidase testing, the antibody reacts with 18 of 22 stomach adenocarcinomas, 11 of 16 colon adenocarcinomas, 3 of 4 squamous cell carcinomas of the lung, and 1 of 4 lung adenocarcinomas. In addition, the antibody reacts with the superficial epithelium of normal tissues such as colon, stomach, esophagus, acinar cells and duct epithelium of the pancreas, bronchial epithelium of the lung, and sweat duct epithelium of the skin. Thus, the CSTO-1 antibody reacts to an antigen present in normal superficial epithelia, as well as on various tumors. It is of potential use in detecting these antigens on tumor sections and eventually may be used in immunotherapy. |
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I ; CHIA, D ; KUKES, G ; MUGISHIMA, H ; KASAI, K ; SUYAMA, N ; FUKUSHIMA, K ; HIROTA, M</creator><creatorcontrib>TOGASHI, H ; TERASAKI, P. I ; CHIA, D ; KUKES, G ; MUGISHIMA, H ; KASAI, K ; SUYAMA, N ; FUKUSHIMA, K ; HIROTA, M</creatorcontrib><description>A monoclonal antibody, CSTO-1, has been produced against a stomach adenocarcinoma-associated antigen. The antibody is cytotoxic to stomach, colon, and lung adenocarcinoma lines but is completely noncytotoxic to normal blood elements and leukemic cell lines. The monoclonal antibody reacts with tumor cell membranes in enzyme-linked immunosorbent assay and is negative to cell membranes from various normal tissues. By immunoperoxidase testing, the antibody reacts with 18 of 22 stomach adenocarcinomas, 11 of 16 colon adenocarcinomas, 3 of 4 squamous cell carcinomas of the lung, and 1 of 4 lung adenocarcinomas. In addition, the antibody reacts with the superficial epithelium of normal tissues such as colon, stomach, esophagus, acinar cells and duct epithelium of the pancreas, bronchial epithelium of the lung, and sweat duct epithelium of the skin. Thus, the CSTO-1 antibody reacts to an antigen present in normal superficial epithelia, as well as on various tumors. It is of potential use in detecting these antigens on tumor sections and eventually may be used in immunotherapy.</description><identifier>ISSN: 0008-5472</identifier><identifier>EISSN: 1538-7445</identifier><identifier>PMID: 6744310</identifier><identifier>CODEN: CNREA8</identifier><language>eng</language><publisher>Philadelphia, PA: American Association for Cancer Research</publisher><subject>adenocarcinoma ; Adenocarcinoma - immunology ; Antibodies, Monoclonal ; antigen (tumor-associated) ; Antigens, Neoplasm - analysis ; Antigens, Surface - analysis ; Biological and medical sciences ; Colonic Neoplasms - immunology ; Cross Reactions ; Cytotoxicity, Immunologic ; Enzyme-Linked Immunosorbent Assay ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; man ; Medical sciences ; monoclonal antibodies ; stomach ; Stomach Neoplasms - immunology ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Cancer research (Chicago, Ill.), 1984-09, Vol.44 (9), p.3952-3956</ispartof><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8989807$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6744310$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TOGASHI, H</creatorcontrib><creatorcontrib>TERASAKI, P. I</creatorcontrib><creatorcontrib>CHIA, D</creatorcontrib><creatorcontrib>KUKES, G</creatorcontrib><creatorcontrib>MUGISHIMA, H</creatorcontrib><creatorcontrib>KASAI, K</creatorcontrib><creatorcontrib>SUYAMA, N</creatorcontrib><creatorcontrib>FUKUSHIMA, K</creatorcontrib><creatorcontrib>HIROTA, M</creatorcontrib><title>A monoclonal antibody, CSTO-1, against a stomach adenocarcinoma-associated antigen</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>A monoclonal antibody, CSTO-1, has been produced against a stomach adenocarcinoma-associated antigen. The antibody is cytotoxic to stomach, colon, and lung adenocarcinoma lines but is completely noncytotoxic to normal blood elements and leukemic cell lines. The monoclonal antibody reacts with tumor cell membranes in enzyme-linked immunosorbent assay and is negative to cell membranes from various normal tissues. By immunoperoxidase testing, the antibody reacts with 18 of 22 stomach adenocarcinomas, 11 of 16 colon adenocarcinomas, 3 of 4 squamous cell carcinomas of the lung, and 1 of 4 lung adenocarcinomas. In addition, the antibody reacts with the superficial epithelium of normal tissues such as colon, stomach, esophagus, acinar cells and duct epithelium of the pancreas, bronchial epithelium of the lung, and sweat duct epithelium of the skin. Thus, the CSTO-1 antibody reacts to an antigen present in normal superficial epithelia, as well as on various tumors. It is of potential use in detecting these antigens on tumor sections and eventually may be used in immunotherapy.</description><subject>adenocarcinoma</subject><subject>Adenocarcinoma - immunology</subject><subject>Antibodies, Monoclonal</subject><subject>antigen (tumor-associated)</subject><subject>Antigens, Neoplasm - analysis</subject><subject>Antigens, Surface - analysis</subject><subject>Biological and medical sciences</subject><subject>Colonic Neoplasms - immunology</subject><subject>Cross Reactions</subject><subject>Cytotoxicity, Immunologic</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>man</subject><subject>Medical sciences</subject><subject>monoclonal antibodies</subject><subject>stomach</subject><subject>Stomach Neoplasms - immunology</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0008-5472</issn><issn>1538-7445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLAzEQAOAgSq3VnyDsQTw1kOcmOZbiCwoFredlNputkd2kbrYH_71RF68yh2Ey3wxDTtCcSq6xEkKeojkhRGMpFDtHFym951JSImdoVmbAKZmj51XRxxBtFwN0BYTR17H5XBbrl90W02UBe_AhjQUUaYw92LcCGpc9DNaH_IAhpWg9jK75md67cInOWuiSu5ryAr3e3-3Wj3izfXharzZ4z7kcsWwbAuAIa4UxRjhBHC2_D3RMENYYpWuhLbTMmRK0hJozm51iUlCriOULdPu79zDEj6NLY9X7ZF3XQXDxmCpNaVkypf6FlBshiTYZXk_wWPeuqQ6D72H4rKbfyv2bqQ_JQtcOEKxPf0ybHETxL-PQchg</recordid><startdate>19840901</startdate><enddate>19840901</enddate><creator>TOGASHI, H</creator><creator>TERASAKI, P. I</creator><creator>CHIA, D</creator><creator>KUKES, G</creator><creator>MUGISHIMA, H</creator><creator>KASAI, K</creator><creator>SUYAMA, N</creator><creator>FUKUSHIMA, K</creator><creator>HIROTA, M</creator><general>American Association for Cancer Research</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19840901</creationdate><title>A monoclonal antibody, CSTO-1, against a stomach adenocarcinoma-associated antigen</title><author>TOGASHI, H ; TERASAKI, P. I ; CHIA, D ; KUKES, G ; MUGISHIMA, H ; KASAI, K ; SUYAMA, N ; FUKUSHIMA, K ; HIROTA, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g335t-5fd0aae02f49994e40e160051e2402d978b48caf2e96a85ab32c99472541c70c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>adenocarcinoma</topic><topic>Adenocarcinoma - immunology</topic><topic>Antibodies, Monoclonal</topic><topic>antigen (tumor-associated)</topic><topic>Antigens, Neoplasm - analysis</topic><topic>Antigens, Surface - analysis</topic><topic>Biological and medical sciences</topic><topic>Colonic Neoplasms - immunology</topic><topic>Cross Reactions</topic><topic>Cytotoxicity, Immunologic</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>man</topic><topic>Medical sciences</topic><topic>monoclonal antibodies</topic><topic>stomach</topic><topic>Stomach Neoplasms - immunology</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOGASHI, H</creatorcontrib><creatorcontrib>TERASAKI, P. I</creatorcontrib><creatorcontrib>CHIA, D</creatorcontrib><creatorcontrib>KUKES, G</creatorcontrib><creatorcontrib>MUGISHIMA, H</creatorcontrib><creatorcontrib>KASAI, K</creatorcontrib><creatorcontrib>SUYAMA, N</creatorcontrib><creatorcontrib>FUKUSHIMA, K</creatorcontrib><creatorcontrib>HIROTA, M</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TOGASHI, H</au><au>TERASAKI, P. I</au><au>CHIA, D</au><au>KUKES, G</au><au>MUGISHIMA, H</au><au>KASAI, K</au><au>SUYAMA, N</au><au>FUKUSHIMA, K</au><au>HIROTA, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A monoclonal antibody, CSTO-1, against a stomach adenocarcinoma-associated antigen</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1984-09-01</date><risdate>1984</risdate><volume>44</volume><issue>9</issue><spage>3952</spage><epage>3956</epage><pages>3952-3956</pages><issn>0008-5472</issn><eissn>1538-7445</eissn><coden>CNREA8</coden><abstract>A monoclonal antibody, CSTO-1, has been produced against a stomach adenocarcinoma-associated antigen. The antibody is cytotoxic to stomach, colon, and lung adenocarcinoma lines but is completely noncytotoxic to normal blood elements and leukemic cell lines. The monoclonal antibody reacts with tumor cell membranes in enzyme-linked immunosorbent assay and is negative to cell membranes from various normal tissues. By immunoperoxidase testing, the antibody reacts with 18 of 22 stomach adenocarcinomas, 11 of 16 colon adenocarcinomas, 3 of 4 squamous cell carcinomas of the lung, and 1 of 4 lung adenocarcinomas. In addition, the antibody reacts with the superficial epithelium of normal tissues such as colon, stomach, esophagus, acinar cells and duct epithelium of the pancreas, bronchial epithelium of the lung, and sweat duct epithelium of the skin. Thus, the CSTO-1 antibody reacts to an antigen present in normal superficial epithelia, as well as on various tumors. It is of potential use in detecting these antigens on tumor sections and eventually may be used in immunotherapy.</abstract><cop>Philadelphia, PA</cop><pub>American Association for Cancer Research</pub><pmid>6744310</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Cancer research (Chicago, Ill.), 1984-09, Vol.44 (9), p.3952-3956 |
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| source | MEDLINE; American Association for Cancer Research; EZB-FREE-00999 freely available EZB journals |
| subjects | adenocarcinoma Adenocarcinoma - immunology Antibodies, Monoclonal antigen (tumor-associated) Antigens, Neoplasm - analysis Antigens, Surface - analysis Biological and medical sciences Colonic Neoplasms - immunology Cross Reactions Cytotoxicity, Immunologic Enzyme-Linked Immunosorbent Assay Gastroenterology. Liver. Pancreas. Abdomen Humans man Medical sciences monoclonal antibodies stomach Stomach Neoplasms - immunology Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | A monoclonal antibody, CSTO-1, against a stomach adenocarcinoma-associated antigen |
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