Hepatic heme metabolism: Possible role of biliverdin in the regulation of heme oxygenase activity

Treatment of rats with biliverdin (48 h) resulted in an increase in microsomal heme oxygenase activity in the liver. This was accompanied by decreases in the microsomal heme and cytochrome P-450 contents. In these respects cellular responses elicited by biliverdin resembled those produced by hematin...

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Veröffentlicht in:	Biochemical and biophysical research communications 1984-07, Vol.122 (1), p.40-46
Hauptverfasser:	Kutty, R.Krishnan, Maines, Mahin D.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Aminolevulinate Synthetase - metabolism Animals Bilirubin - analogs & derivatives biliverdin biliverdin reductase Biliverdine - physiology Cytochrome P-450 Enzyme Inhibitors Heme - metabolism heme oxidase Heme Oxygenase (Decyclizing) - metabolism Hemin - physiology In Vitro Techniques liver Male Microsomes, Liver - enzymology Mixed Function Oxygenases - metabolism Oxidoreductases - metabolism Oxidoreductases Acting on CH-CH Group Donors Rats Rats, Inbred Strains
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