Effect of Zajdela ascites hepatoma on the activity and synthesis of liver histidase of tumor-bearing rats
The synthesis of histidase occurs only in free polyribosomes. The relative content of histidase synthesizing polyribosomes in rat liver, in Zajdela ascites hepatoma cells and in the liver of tumor-bearing rats is equal to 1.35%, 0.11% and 0.57%, respectively (of the total amount of free polyribosome...
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| Veröffentlicht in: | Cancer letters 1984-05, Vol.23 (1), p.67-71 |
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| container_end_page | 71 |
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| container_issue | 1 |
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| container_title | Cancer letters |
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| creator | Fedorov, Sergei A. Khasigov, Pyotr Z. Nocolaev, Alexander Ya |
| description | The synthesis of histidase occurs only in free polyribosomes. The relative content of histidase synthesizing polyribosomes in rat liver, in Zajdela ascites hepatoma cells and in the liver of tumor-bearing rats is equal to 1.35%, 0.11% and 0.57%, respectively (of the total amount of free polyribosomes). It was found that hepatoma cell sap has an inhibitory effect on the synthesis of proteins in the cell-free system reconstructed from polyribosomes and cell sap of control rats. |
| doi_str_mv | 10.1016/0304-3835(84)90063-6 |
| format | Article |
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The relative content of histidase synthesizing polyribosomes in rat liver, in Zajdela ascites hepatoma cells and in the liver of tumor-bearing rats is equal to 1.35%, 0.11% and 0.57%, respectively (of the total amount of free polyribosomes). It was found that hepatoma cell sap has an inhibitory effect on the synthesis of proteins in the cell-free system reconstructed from polyribosomes and cell sap of control rats.</description><identifier>ISSN: 0304-3835</identifier><identifier>EISSN: 1872-7980</identifier><identifier>DOI: 10.1016/0304-3835(84)90063-6</identifier><identifier>PMID: 6744236</identifier><identifier>CODEN: CALEDQ</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Ammonia-Lyases - biosynthesis ; Animal tumors. Experimental tumors ; Animals ; Biological and medical sciences ; Brain - metabolism ; Cell Fractionation ; Cell Line ; Experimental digestive system and abdominal tumors ; Histidine Ammonia-Lyase - antagonists & inhibitors ; Histidine Ammonia-Lyase - biosynthesis ; Liver - enzymology ; Liver Neoplasms, Experimental - metabolism ; Male ; Medical sciences ; Neoplasm Transplantation ; Polyribosomes - metabolism ; Rats ; Rats, Inbred Strains ; Tissue Extracts - pharmacology ; Tumors</subject><ispartof>Cancer letters, 1984-05, Vol.23 (1), p.67-71</ispartof><rights>1984</rights><rights>1984 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c335t-218312efb31d8aaea9023fe30b78ba0e3686bef4baeffc1a4cf461c251536c9b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0304-3835(84)90063-6$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27922,27923,45993</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=9637361$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6744236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fedorov, Sergei A.</creatorcontrib><creatorcontrib>Khasigov, Pyotr Z.</creatorcontrib><creatorcontrib>Nocolaev, Alexander Ya</creatorcontrib><title>Effect of Zajdela ascites hepatoma on the activity and synthesis of liver histidase of tumor-bearing rats</title><title>Cancer letters</title><addtitle>Cancer Lett</addtitle><description>The synthesis of histidase occurs only in free polyribosomes. The relative content of histidase synthesizing polyribosomes in rat liver, in Zajdela ascites hepatoma cells and in the liver of tumor-bearing rats is equal to 1.35%, 0.11% and 0.57%, respectively (of the total amount of free polyribosomes). It was found that hepatoma cell sap has an inhibitory effect on the synthesis of proteins in the cell-free system reconstructed from polyribosomes and cell sap of control rats.</description><subject>Ammonia-Lyases - biosynthesis</subject><subject>Animal tumors. Experimental tumors</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Cell Fractionation</subject><subject>Cell Line</subject><subject>Experimental digestive system and abdominal tumors</subject><subject>Histidine Ammonia-Lyase - antagonists & inhibitors</subject><subject>Histidine Ammonia-Lyase - biosynthesis</subject><subject>Liver - enzymology</subject><subject>Liver Neoplasms, Experimental - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Transplantation</subject><subject>Polyribosomes - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Tissue Extracts - pharmacology</subject><subject>Tumors</subject><issn>0304-3835</issn><issn>1872-7980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhoMo6-zqP1DIQUQPrUknnU5fBFl2VVjwohcvoTpdcbL0x5jKDMy_N-0Mc_RUUPW8RfEUY6-k-CCFNB-FErpSVjXvrH7fCWFUZZ6wjbRtXbWdFU_Z5oI8Z9dEj0KIRrfNFbsyrda1MhsW70JAn_kS-C94HHAEDuRjRuJb3EFeJuDLzPMWOfgcDzEfOcwDp-NcehRpTY7xgIlvI-U4AOHayvtpSVWPkOL8myfI9II9CzASvjzXG_bz_u7H7dfq4fuXb7efHyqvVJOrWlolawy9koMFQOhErQIq0be2B4HKWNNj0D1gCF6C9kEb6etGNsr4rlc37O1p7y4tf_ZI2U2RPI4jzLjsyVkpjdJSFFCfQJ8WooTB7VKcIB2dFG417FZ9btXnrHb_DDtTYq_P-_f9hMMldFZa5m_O8yISxpBg9pEuWGdUq4ws2KcThsXFIWJyRTvOHoeYykPcsMT_3_EXvkiYow</recordid><startdate>198405</startdate><enddate>198405</enddate><creator>Fedorov, Sergei A.</creator><creator>Khasigov, Pyotr Z.</creator><creator>Nocolaev, Alexander Ya</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198405</creationdate><title>Effect of Zajdela ascites hepatoma on the activity and synthesis of liver histidase of tumor-bearing rats</title><author>Fedorov, Sergei A. ; Khasigov, Pyotr Z. ; Nocolaev, Alexander Ya</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c335t-218312efb31d8aaea9023fe30b78ba0e3686bef4baeffc1a4cf461c251536c9b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Ammonia-Lyases - biosynthesis</topic><topic>Animal tumors. Experimental tumors</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Cell Fractionation</topic><topic>Cell Line</topic><topic>Experimental digestive system and abdominal tumors</topic><topic>Histidine Ammonia-Lyase - antagonists & inhibitors</topic><topic>Histidine Ammonia-Lyase - biosynthesis</topic><topic>Liver - enzymology</topic><topic>Liver Neoplasms, Experimental - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasm Transplantation</topic><topic>Polyribosomes - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Tissue Extracts - pharmacology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fedorov, Sergei A.</creatorcontrib><creatorcontrib>Khasigov, Pyotr Z.</creatorcontrib><creatorcontrib>Nocolaev, Alexander Ya</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fedorov, Sergei A.</au><au>Khasigov, Pyotr Z.</au><au>Nocolaev, Alexander Ya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Zajdela ascites hepatoma on the activity and synthesis of liver histidase of tumor-bearing rats</atitle><jtitle>Cancer letters</jtitle><addtitle>Cancer Lett</addtitle><date>1984-05</date><risdate>1984</risdate><volume>23</volume><issue>1</issue><spage>67</spage><epage>71</epage><pages>67-71</pages><issn>0304-3835</issn><eissn>1872-7980</eissn><coden>CALEDQ</coden><abstract>The synthesis of histidase occurs only in free polyribosomes. The relative content of histidase synthesizing polyribosomes in rat liver, in Zajdela ascites hepatoma cells and in the liver of tumor-bearing rats is equal to 1.35%, 0.11% and 0.57%, respectively (of the total amount of free polyribosomes). It was found that hepatoma cell sap has an inhibitory effect on the synthesis of proteins in the cell-free system reconstructed from polyribosomes and cell sap of control rats.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>6744236</pmid><doi>10.1016/0304-3835(84)90063-6</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3835 |
| ispartof | Cancer letters, 1984-05, Vol.23 (1), p.67-71 |
| issn | 0304-3835 1872-7980 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Ammonia-Lyases - biosynthesis Animal tumors. Experimental tumors Animals Biological and medical sciences Brain - metabolism Cell Fractionation Cell Line Experimental digestive system and abdominal tumors Histidine Ammonia-Lyase - antagonists & inhibitors Histidine Ammonia-Lyase - biosynthesis Liver - enzymology Liver Neoplasms, Experimental - metabolism Male Medical sciences Neoplasm Transplantation Polyribosomes - metabolism Rats Rats, Inbred Strains Tissue Extracts - pharmacology Tumors |
| title | Effect of Zajdela ascites hepatoma on the activity and synthesis of liver histidase of tumor-bearing rats |
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