Dopaminergic neurons in the mediobasal hypothalamus of old rats: Evidence for decreased affinity of tyrosine hydroxylase for substrate and cofactor

The effect of aging on the activity of tyrosine hydroxylase (TH) and on the number of TH-positive perikarya in the hypothalamus was studied in old and young female rats. The activity of TH in the mediobasal hypothalamus (MBH) of old rats was significantly ( P < 0.025) less than that in young rats...

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Veröffentlicht in:	Brain research 1984-06, Vol.304 (2), p.215-223
Hauptverfasser:	Reymond, Marianne J., Arita, Jun, Dudley, Carol A., Moss, Robert L., Porter, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors aging Animals Dihydroxyphenylalanine - biosynthesis DOPA synthesis Dopamine - metabolism dopaminergic neurons enzyme kinetics Female Hypothalamus - metabolism Hypothalamus, Middle - enzymology immunocytochemistry Immunoenzyme Techniques Kinetics mediobasal hypothalamus Pterins - metabolism Rats Tyrosine - metabolism Tyrosine 3-Monooxygenase - metabolism tyrosine hydroxylase
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