morphogenesis and cytopathology of bovine parainfluenza type 3 virus
Department of Microbiology, School of Hygiene, University of Toronto, Toronto, Canada The structure of bovine parainfluenza type 3 virus (strain SF -4) was found to be indistinguishable from that of other paramyxoviruses. Negatively stained virus particles had an overall diameter ranging from 280 to...
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| Veröffentlicht in: | Journal of general virology 1971-09, Vol.12 (3), p.271-279 |
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| container_title | Journal of general virology |
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| creator | McLean, A.M Doane, F.W |
| description | Department of Microbiology, School of Hygiene, University of Toronto, Toronto, Canada
The structure of bovine parainfluenza type 3 virus (strain SF -4) was found to be indistinguishable from that of other paramyxoviruses. Negatively stained virus particles had an overall diameter ranging from 280 to 580 nm. and a nucleocapsid diameter of 17 to 19 nm. By light microscopy, SF -4-infected LLC-MK2 cells showed eosinophilic cytoplasmic inclusions, followed later by eosinophilic nuclear inclusions. By electron microscopy, aggregates of nucleocapsid-like filaments were seen in the cytoplasm and nucleus. Maturation of virus particles occurred at the plasma membrane, in a manner similar to that observed with other paramyxoviruses. Some cells containing inclusions exhibited an unusual type of particle formation in dilated portions of the endoplasmic reticulum. Bovine parainfluenza 3 virus appears to be unique among parainfluenza viruses in that its cytopathology and morphogenesis more closely resemble that of the unrelated measles subgroup of paramyxoviruses than that of the antigenically related parainfluenza viruses.
* Submitted to the University of Toronto in partial fulfilment of the requirement for the Master of Science degree.
Received 15 March 1971;
accepted 23 April 1971. |
| doi_str_mv | 10.1099/0022-1317-12-3-271 |
| format | Article |
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The structure of bovine parainfluenza type 3 virus (strain SF -4) was found to be indistinguishable from that of other paramyxoviruses. Negatively stained virus particles had an overall diameter ranging from 280 to 580 nm. and a nucleocapsid diameter of 17 to 19 nm. By light microscopy, SF -4-infected LLC-MK2 cells showed eosinophilic cytoplasmic inclusions, followed later by eosinophilic nuclear inclusions. By electron microscopy, aggregates of nucleocapsid-like filaments were seen in the cytoplasm and nucleus. Maturation of virus particles occurred at the plasma membrane, in a manner similar to that observed with other paramyxoviruses. Some cells containing inclusions exhibited an unusual type of particle formation in dilated portions of the endoplasmic reticulum. Bovine parainfluenza 3 virus appears to be unique among parainfluenza viruses in that its cytopathology and morphogenesis more closely resemble that of the unrelated measles subgroup of paramyxoviruses than that of the antigenically related parainfluenza viruses.
* Submitted to the University of Toronto in partial fulfilment of the requirement for the Master of Science degree.
Received 15 March 1971;
accepted 23 April 1971.</description><identifier>ISSN: 0022-1317</identifier><identifier>EISSN: 1465-2099</identifier><identifier>DOI: 10.1099/0022-1317-12-3-271</identifier><identifier>PMID: 4107528</identifier><language>eng</language><publisher>England: Soc General Microbiol</publisher><subject>animal diseases ; animal health ; Animals ; Cell Line ; Cell Membrane - microbiology ; Cell Nucleus - microbiology ; Cytopathogenic Effect, Viral ; Cytoplasm - microbiology ; Endoplasmic Reticulum - microbiology ; Haplorhini ; Inclusion Bodies, Viral ; Kidney ; Microscopy, Electron ; Morphogenesis ; Nucleoproteins ; Respirovirus - growth & development ; Respirovirus - pathogenicity ; Species Specificity ; Staining and Labeling ; Virus Replication</subject><ispartof>Journal of general virology, 1971-09, Vol.12 (3), p.271-279</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c398t-8950debffcd89a8102401989dd69d8fc94492d78a9d3d2c14cac1bd40b8577063</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3733,3734,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/4107528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>McLean, A.M</creatorcontrib><creatorcontrib>Doane, F.W</creatorcontrib><title>morphogenesis and cytopathology of bovine parainfluenza type 3 virus</title><title>Journal of general virology</title><addtitle>J Gen Virol</addtitle><description>Department of Microbiology, School of Hygiene, University of Toronto, Toronto, Canada
The structure of bovine parainfluenza type 3 virus (strain SF -4) was found to be indistinguishable from that of other paramyxoviruses. Negatively stained virus particles had an overall diameter ranging from 280 to 580 nm. and a nucleocapsid diameter of 17 to 19 nm. By light microscopy, SF -4-infected LLC-MK2 cells showed eosinophilic cytoplasmic inclusions, followed later by eosinophilic nuclear inclusions. By electron microscopy, aggregates of nucleocapsid-like filaments were seen in the cytoplasm and nucleus. Maturation of virus particles occurred at the plasma membrane, in a manner similar to that observed with other paramyxoviruses. Some cells containing inclusions exhibited an unusual type of particle formation in dilated portions of the endoplasmic reticulum. Bovine parainfluenza 3 virus appears to be unique among parainfluenza viruses in that its cytopathology and morphogenesis more closely resemble that of the unrelated measles subgroup of paramyxoviruses than that of the antigenically related parainfluenza viruses.
* Submitted to the University of Toronto in partial fulfilment of the requirement for the Master of Science degree.
Received 15 March 1971;
accepted 23 April 1971.</description><subject>animal diseases</subject><subject>animal health</subject><subject>Animals</subject><subject>Cell Line</subject><subject>Cell Membrane - microbiology</subject><subject>Cell Nucleus - microbiology</subject><subject>Cytopathogenic Effect, Viral</subject><subject>Cytoplasm - microbiology</subject><subject>Endoplasmic Reticulum - microbiology</subject><subject>Haplorhini</subject><subject>Inclusion Bodies, Viral</subject><subject>Kidney</subject><subject>Microscopy, Electron</subject><subject>Morphogenesis</subject><subject>Nucleoproteins</subject><subject>Respirovirus - growth & development</subject><subject>Respirovirus - pathogenicity</subject><subject>Species Specificity</subject><subject>Staining and Labeling</subject><subject>Virus Replication</subject><issn>0022-1317</issn><issn>1465-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1971</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkE1LxDAURYMoOo7-AUHsSlfVvCRtk6WMnzDgQl2HNElnIm1Tk1apv94OM4irt7jn3gcHoTPA14CFuMGYkBQoFCmQlKakgD00A5ZnKZnifTT7A47QcYwfGANjWXGIDhngIiN8hu4aH7q1X9nWRhcT1ZpEj73vVL_2tV-Nia-S0n-51iadCsq1VT3Y9kcl_djZhCZfLgzxBB1Uqo72dHfn6P3h_m3xlC5fHp8Xt8tUU8H7lIsMG1tWlTZcKA6YMAyCC2NyYXilBWOCmIIrYaghGphWGkrDcMmzosA5naPL7W4X_OdgYy8bF7Wta9VaP0TJAXLIMzyBZAvq4GMMtpJdcI0KowQsN-rkxozcmJFAJJWTuql0vlsfysaav8rO1ZRfbfO1W62_XbBysta46UXpvJxE_Fu62JKV8lKtgovy_ZVgoBiAkkxQ-gvPKYCP</recordid><startdate>197109</startdate><enddate>197109</enddate><creator>McLean, A.M</creator><creator>Doane, F.W</creator><general>Soc General Microbiol</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197109</creationdate><title>morphogenesis and cytopathology of bovine parainfluenza type 3 virus</title><author>McLean, A.M ; Doane, F.W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c398t-8950debffcd89a8102401989dd69d8fc94492d78a9d3d2c14cac1bd40b8577063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1971</creationdate><topic>animal diseases</topic><topic>animal health</topic><topic>Animals</topic><topic>Cell Line</topic><topic>Cell Membrane - microbiology</topic><topic>Cell Nucleus - microbiology</topic><topic>Cytopathogenic Effect, Viral</topic><topic>Cytoplasm - microbiology</topic><topic>Endoplasmic Reticulum - microbiology</topic><topic>Haplorhini</topic><topic>Inclusion Bodies, Viral</topic><topic>Kidney</topic><topic>Microscopy, Electron</topic><topic>Morphogenesis</topic><topic>Nucleoproteins</topic><topic>Respirovirus - growth & development</topic><topic>Respirovirus - pathogenicity</topic><topic>Species Specificity</topic><topic>Staining and Labeling</topic><topic>Virus Replication</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McLean, A.M</creatorcontrib><creatorcontrib>Doane, F.W</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of general virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McLean, A.M</au><au>Doane, F.W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>morphogenesis and cytopathology of bovine parainfluenza type 3 virus</atitle><jtitle>Journal of general virology</jtitle><addtitle>J Gen Virol</addtitle><date>1971-09</date><risdate>1971</risdate><volume>12</volume><issue>3</issue><spage>271</spage><epage>279</epage><pages>271-279</pages><issn>0022-1317</issn><eissn>1465-2099</eissn><abstract>Department of Microbiology, School of Hygiene, University of Toronto, Toronto, Canada
The structure of bovine parainfluenza type 3 virus (strain SF -4) was found to be indistinguishable from that of other paramyxoviruses. Negatively stained virus particles had an overall diameter ranging from 280 to 580 nm. and a nucleocapsid diameter of 17 to 19 nm. By light microscopy, SF -4-infected LLC-MK2 cells showed eosinophilic cytoplasmic inclusions, followed later by eosinophilic nuclear inclusions. By electron microscopy, aggregates of nucleocapsid-like filaments were seen in the cytoplasm and nucleus. Maturation of virus particles occurred at the plasma membrane, in a manner similar to that observed with other paramyxoviruses. Some cells containing inclusions exhibited an unusual type of particle formation in dilated portions of the endoplasmic reticulum. Bovine parainfluenza 3 virus appears to be unique among parainfluenza viruses in that its cytopathology and morphogenesis more closely resemble that of the unrelated measles subgroup of paramyxoviruses than that of the antigenically related parainfluenza viruses.
* Submitted to the University of Toronto in partial fulfilment of the requirement for the Master of Science degree.
Received 15 March 1971;
accepted 23 April 1971.</abstract><cop>England</cop><pub>Soc General Microbiol</pub><pmid>4107528</pmid><doi>10.1099/0022-1317-12-3-271</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of general virology, 1971-09, Vol.12 (3), p.271-279 |
| issn | 0022-1317 1465-2099 |
| language | eng |
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| source | MEDLINE; Microbiology Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | animal diseases animal health Animals Cell Line Cell Membrane - microbiology Cell Nucleus - microbiology Cytopathogenic Effect, Viral Cytoplasm - microbiology Endoplasmic Reticulum - microbiology Haplorhini Inclusion Bodies, Viral Kidney Microscopy, Electron Morphogenesis Nucleoproteins Respirovirus - growth & development Respirovirus - pathogenicity Species Specificity Staining and Labeling Virus Replication |
| title | morphogenesis and cytopathology of bovine parainfluenza type 3 virus |
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