Metabolism of harmaline in rats

The distribution and metabolic fate of [ 3H]harmaline-HCl were studied in rats. Thirty min after subcutaneous injection, high radioactivity was found in the small intestine, liver, adrenals, kidneys and lungs. A rapid turnover and elimination was evident after the first hour, as most of the tissues,...

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Veröffentlicht in:	Biochemical pharmacology 1971-06, Vol.20 (6), p.1313,IN11,1317-1316,IN12,1319
Hauptverfasser:	Ho, Beng T., Estevez, Vicente, Fritchie, G.Edward, Tansey, L.Wayne, Idänpään-Heikkilä, Juhana, McIsaac, William M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Glands - metabolism Alkaloids - blood Alkaloids - metabolism Alkaloids - urine Animals Autoradiography Blood Proteins - metabolism Brain - metabolism Chromatography, Gel Chromatography, Paper Chromatography, Thin Layer Dealkylation Ethers - blood Ethers - metabolism Ethers - urine Feces - analysis Female Fluorometry Glucuronates - urine Humans Indoles - metabolism Intestine, Large - metabolism Intestine, Small - metabolism Kidney - metabolism Kinetics Liver - metabolism Lung - metabolism Muscles - metabolism Myocardium - metabolism Ovary - metabolism Oxidation-Reduction Phenols - urine Protein Binding Pyridines - metabolism Rats Spleen - metabolism Sulfuric Acids - urine Tritium
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